Browse Results

Showing 65,526 through 65,550 of 100,000 results

Atypical Elements in Drug Design (Topics in Medicinal Chemistry #17)

by Jacob Schwarz

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Atypical Interaction: The Impact of Communicative Impairments within Everyday Talk

by Ray Wilkinson John P. Rae Gitte Rasmussen

Atypical Interaction presents a state-of-the-art overview of research which uses conversation analysis to explore how communicative impairments impact on conversation and other forms of talk and social interaction. Although the majority of people use spoken language unproblematically in social interaction, many individuals have an atypical capacity for communication. The first collection of its kind, this book examines a wide range of conditions where the communication of children or adults is atypical, including autism spectrum disorder, dementia, stammering, hearing impairment, schizophrenia, dysarthria and aphasia. By analyzing recordings of real-life interactions, the collection highlights not only the communication difficulties and challenges faced by atypical communicators and their interlocutors in everyday life, but also the competences and often novel forms of communication displayed. With fourteen empirical chapters from leading scholars in the field and an introductory chapter which provides a background to conversation analysis and its application to the study of atypical interactions, the collection will be an invaluable resource for students, practitioners such as speech and language therapists, and researchers with an interest in human communication, communication diversity and disorder.

The Atypical Mycobacteria and Human Mycobacteriosis (Current Topics in Infectious Disease)

by John Chapman

Nearly twenty years ago a symposium convened at Dallas, Texas, to con­ sider the place of atypical mycobacteria among agents of human disease. An edited and condensed version of that symposium was subsequently published and since that time has constituted the only bound source of infor­ mation covering broad aspects of mycobacterial disease. In the years since a vast amount of information has accumulated in periodical literature, some of which is not readily accessible. The time seems suitable for a comprehensive collection of this scattered material into a single book. The aim has not been to produce an exhaustive account of mycobacteria and mycobacterioses, but rather to concentrate on salient points and particularly on those most generally useful to a diverse group of interests: mycobacteriology, pathology, epidemiology, and, of course, clinical fields. In Appendix A there appear in summary form manifestations of myco­ bacteria as they have occurred among clinical specialities, such as ortho­ pedic surgery, dermatology, and urology. These summaries are designed to serve as guides to more probable infections and to lead to more extensive reading with respect to the specific organism encountered. Appendix C presents, also in summary form, drugs, regimens, duration of treatment, and toxicities to permit ready reference to less familiar anti­ microbial agents. These are suggestive only, useful when the general nature of the organism is known but not the specific susceptibility of the individual strain.

Atypical Parkinsonian Disorders: Clinical and Research Aspects (Current Clinical Neurology)

by Irene Litvan

A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.

Atypische Beschäftigung und ihre sozialen Konsequenzen (Familienforschung)

by Daniel Baron Paul B. Hill

Der vorliegende Band führt empirische Forschungsresultate aus unterschiedlichen Teilgebieten der Familien- und Arbeitsmarktsoziologie zusammen, die sich der Untersuchung der Folgen atypischer Beschäftigung für Familien und Partnerschaften widmen. Das Ziel des Bandes besteht darin, sowohl Impulse für zukünftige Forschungsansätze zu geben als auch empirisch fundierte Praxisbezüge jüngster Beiträge in diesem Forschungsfeld aufzuzeigen. Im Anschluss an einen handlungstheoretischen und empirischen Überblick werden Ansätze zur empirischen Messung der subjektiven Belastung infolge atypischer Beschäftigung aufgearbeitet und empirisch überprüft. Danach werden Folgen atypischer Beschäftigungsverhältnisse auf einzelne Teilbereiche des Familienlebens fokussiert: Die Ausprägungen des Kinderwunschs junger Erwachsener, partnerschaftliche Institutionalisierungsprozesse, die Aufteilung der Kinderbetreuung unter jungen Paaren sowie die Ausprägungen und Folgen migrantischer Pflegearbeit. Ergänzt werden die Studien um eine international vergleichende Perspektive. Am Ende des Bandes werden darüber hinaus praktische Empfehlungen für die zukünftige Regulierung atypischer Beschäftigungsverhältnisse mit dem Fokus auf sozial- und familienpolitische Implikationen gegeben.

Au-Catalyzed Synthesis and Functionalization of Heterocycles (Topics in Heterocyclic Chemistry #46)

by Marco Bandini

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal

Au Contraire!: Figuring Out the French (Interact Ser.)

by Ruth Mastron Gilles Asselin

The French are famously enigmatic: fiercely independent yet deeply romantic,conservative yet avant-garde, rational yet emotional. What is it, exactly, that makes the French so... French? Written for anyone interacting with the French - tourists, businesspeople, international students, Francophiles - Au Contraire! offers a perceptive understanding of French cultural beliefs, assumptions and attitudes, along with practical advice on building strong personal and professional relationships with the French. Addressing issues like friendship, politics, work, education and romance, bilingual and bi cultural authors Asselin and Mastron draw upon their own experiences as consultants and trainers, as well as those of students and professionals, giving readers a complete - and compelling - look at French culture. This revised edition of Au Contraire! includes updated information about France's changing social and political climate, advice for succeeding as an expat, information about the French educational system, overviews of France's diverse regions - and more.

Au-delà de l'information, la prévention: Par l’équipe du département de prévention Épidaure (Dépistage et cancer)

by Hélène Sancho-Garnier Daniel Serin

La prévention des pathologies les plus fréquentes et les plus mortelles (cancers, maladies cardiovasculaires, accidents) passe essentiellement par la modification des comportements à risque, défi qui ne peut être résolu par la simple diffusion d’informations. Pour pouvoir modifier les comportements, il faut tenir compte d’une part, des individus eux-mêmes et de ce qui les amène à changer leurs manières de vivre et, d’autre part, de l’environnement culturel, social, physique et économique qui façonne les personnes et dont les modifications sont nécessaires aux changements individuels. Ainsi, les actions de prévention en matière de santé sont efficaces pour autant qu’elles renforcent la capacité à exercer un contrôle sur les déterminants de santé individuels et collectifs. Pour être plus efficaces, les programmes doivent donc inclure des stratégies multiples dont l’objectif est à la fois de changer le contexte sociétal et de changer les valeurs de vie des individus. Le centre de prévention Épidaure, ouvert en 1988, a pour mission la prévention des cancers. Son équipe pluridisciplinaire organise son activité autour de trois axes : recherche en pédagogie et préventologie, formation dans les mêmes domaines et mise en place, avec divers partenaires, d’interventions de prévention. C’est le fruit de ces quinze années d’expérience que l’équipe d’Épidaure a voulu transmettre dans ce livre, une partie théorique sur les possibilités d’action sur les comportements et une partie plus pratique rapportant les expériences d’Épidaure et les réflexions qui en découlent. Le dernier chapitre traite de l’évaluation des actions de prévention, domaine encore assez peu exploré et qu’Épidaure s’efforce de mettre en place.

Au Pair

by Daniel Miller Zuzana Burikova

Many families leave their children for years to be looked after by young people about whom they know next to nothing, from places they have barely heard of. Who are these au pairs, why do they come and what is their experience of this arrangement? Do they, for their part, find that they are treated as one of the family, and would they even want to be? After a year of careful research, this book shows how most of our assumptions and expectations about au pairs are wrong. This is the first book devoted to the lives of au pairs, their leisure as well as their work time. We see this world from the eyes of the visitors, and their unique perspective on what lies at the heart of our family life. The book does not flinch from documenting the realities of the situation Ð the racism and the problematic behaviour of the au pairs themselves, as much as the ignorance and exploitation they can be subject to. The book is a case study in how to come to feel modern life empathetically from the viewpoint of one of those many migrant groups we take for granted and rely on but rarely try to understand.

Au Pair

by Daniel Miller Zuzana Burikova

Many families leave their children for years to be looked after by young people about whom they know next to nothing, from places they have barely heard of. Who are these au pairs, why do they come and what is their experience of this arrangement? Do they, for their part, find that they are treated as one of the family, and would they even want to be? After a year of careful research, this book shows how most of our assumptions and expectations about au pairs are wrong. This is the first book devoted to the lives of au pairs, their leisure as well as their work time. We see this world from the eyes of the visitors, and their unique perspective on what lies at the heart of our family life. The book does not flinch from documenting the realities of the situation Ð the racism and the problematic behaviour of the au pairs themselves, as much as the ignorance and exploitation they can be subject to. The book is a case study in how to come to feel modern life empathetically from the viewpoint of one of those many migrant groups we take for granted and rely on but rarely try to understand.

Au Pairs' Lives in Global Context: Sisters or Servants? (Migration, Diasporas and Citizenship)

by Rosie Cox

Far from being the preserve of middle-class women from Northern Europe, au pairing is now booming worldwide. This collection, the first dedicated entirely to examining the lives of au pairs, traces their experiences across five continents showing how this form of domestic labour and childcare is thriving in the twenty-first century.

Au Revoir Britannia

by Sylvie Bermann

From her unique perspective as former French ambassador to the UK, Sylvie Bermann examines the mistruths told by politicians surrounding the fateful 2016 Brexit referendum. Au Revoir Britannia asks the question ‘How did this happen?’ and exposes what she sees as the ‘unrepenting’ and ‘inveterate’ lies of the now pm, Boris Johnson. This first English edition includes a new preface exploring the future of post-Brexit Europe and Britain, and the uncertain implications of the Russian invasion of Ukraine.

Au Revoir, Europe: What if Britain left the EU?

by David Charter

Forty years ago, Britain joined the club of European nations. The idea was to guarantee peace and prosperity on the continent through 'ever closer union' following centuries of terrible wars. But after four decades of membership, costing the UK more than ?200 billion, public disenchantment with the European Union has never been so great. In Au Revoir, Europe David Charter, Europe Correspondent for The Times, looks at what went wrong - and what happens next. It charts Britain's increasing detachment from the European project amid a barrage of bureaucracy, mindboggling expenditure and concern at sharing sovereignty for goals that were never truly embraced. From trade to transport, fishing to finance, investment to immigration, the decision that Britain takes on its future relationship with Brussels will touch many parts of everyday life. In presenting the unvarnished truth of what it would really mean for Britain to say goodbye, this book is a unique contribution to the European debate and essential reading for all.

Au Revoir Liverpool

by Maureen Lee

A gripping Second World War novel, from the bestselling author of NOTHING LASTS FOREVER and THE LEAVING OF LIVERPOOL.Liverpool, 1937. Jessica is married to Bertie, a mean, patronising man who she has stayed with purely for the sake of her two young children. To make up for the love and passion that is missing from her life, she spends the occasional afternoon at the local cinema, lost in romantic films. But when an unexpected glass of champagne is offered to her in a Liverpool hotel, the consequences turn out to be shattering.When Bertie discovers his wife's deceit, he is ruthless in his revenge. He sells their house and disappears with her beloved children, leaving Jessica devastated and alone. Then she is asked to visit Paris and help an old friend and her small daughters return to Liverpool before the onset of the war. But Jessica finds herself stranded in Paris under German occupation. With new friends and a small family to care for, she must find the courage that she never knew she possessed...

Au Revoir to All That: The Rise and Fall of French Cuisine

by Michael Steinberger

Au Revoir to All That takes us on an entertaining and intriguing journey into France's identity, directly through the tastebuds... Offering a fresh and entertaining approach to understanding French history, through its food and wine, Steinberger reveals a radically changing France; a country moving through social and political reform, economic crises and, importantly, the loss of their seemingly unbreakable dominance in all things gastronomical. If the state of France's celebrated cuisine is the bellwether for the state of the nation, things are looking bleak. Top chefs are renouncing their Michelin stars and prized farmhouse cheeses are going extinct because there is no one to make them. Bistros, brasseries and cafés fold by the scores and hypermarkets and superstores account for 75% of retail food sales. The famed wine-producing Languedoc is home to the world's first wine-terrorist organization - winemakers resorting to violence to protect their struggling industry. But while there may be better baguettes in Tokyo than in Paris, and Spain has become the darling of the gastronomic world, there are glimpses of hope. There are up-and-coming culinary stars and outdoor food festivals, pockets of exuberance amid the gloom. And, as long as a praline millefeuille can be celebrated, savoured and allowed to assume talismanic qualities at a Right Bank tea salon, all is not lost. Au Revoir to All That is an essential - almost edible - book for lovers of food, France and culinary history.

Au Revoir to All That: Food, Wine, and the End of France

by Michael Steinberger

France is in a rut, and so is French cuisine. Twenty-five years ago it was hard to have a bad meal in France; now, in some cities and towns, it is a challenge to find a good one. For the first time in the annals of modern cuisine, the most influential chefs and the most talked-about restaurants in the world are not French. Within France, large segments of the wine industry are in crisis, cherished artisanal cheeses are threatened with extinction, and bistros and brasseries are disappearing at an alarming rate. But business is brisk at some establishments: Astonishingly, France has become the second most-profitable market in the world for McDonald's. In an enviable trip through the traditional pleasures of France, Steinberger talks to top chefs-Ducasse, Gagnaire, Bocuse-winemakers, farmers, bakers, and other artisans. He visits the Elysée Palace, interviews the head of McDonald's Europe, marches down a Paris boulevard with Jose Bove, and breaks bread with the editorial director of the powerful and secretive Michelin Guide. He spends hours with some of France's brightest young chefs and winemakers, who are battling to reinvigorate the country's rich culinary heritage. Throughout, Steinberger remains an unabashed and steadfast Francophile, and his own sharp and funny reflections bring empathy to this striking portrait of a cuisine and a country in transition.

The Aubergine Cookbook: 50 Recipes To Feed Your Aubergine Obsession

by Heather Thomas

Feed your aubergine obsession!Discover surprising new ways to cook, serve and eat this king of veg. No longer the 'poor man's meat', aubergine can be transformed into impressive dishes with these 60 brand new recipes ranging from Aubergine Fritters with Honey and Goats Cheese, to Sicilian Aubergine Pizza, Persian Stuffed Aubergine, and even Aubergine Chocolate Cake.Whip up exotic yet simple mid-week suppers, impress friends and feed a crowd, and even convert aubergine haters with these creative and delicious recipes, packed with flavour.

Aubrey's Brief Lives

by John Aubrey Oliver Lawson Dick

WITH AN INTRODUCTION BY RUTH SCURRJohn Aubrey was a modest man, a self-styled antiquarian and the man who invented modern biography. His ‘lives’ of the prominent figures of his generation and the Elizabethan era, including Shakespeare, Milton and Sir Walter Raleigh, have been plundered by historians for centuries for their frankness and fascinating detail. Collected here are all of Aubrey’s biographical writings, a series of unforgettable portraits of the characters of his day, still more alive and kicking than in any conventional work of history.

AUC 2019: Proceedings of the 15th International Asian Urbanization Conference, Vietnam (Advances in 21st Century Human Settlements)

by Le Thi Thu Huong George M. Pomeroy

This book presents selected articles from the 15th International Asian Urbanization Conference, held in Ho Chi Minh City, Vietnam, on November 27-30, 2019. Bringing together researchers and professionals in the area of urban planning and development to better understand the growing need for sustainable urban life, it covers topics such as climate change and urban resilience; inclusive and implementable urban governance; smart and green mobility; transformations in land management; livable and smart cities; integrated planning and development; urban slums and affordable housing; sustainable urban finance; and urban renewal and redevelopment.

Auca am Cononaco: Indianer im ecuadorianischen Regenwald

by BROENNIMANN

Auca on the Cononaco: Indians of the Ecuadorian Rain Forest

by BROENNIMANN

Auch alte Bäume wachsen noch: Zur Psychologie des höheren Lebensalters - mit Aufgaben und Übungen für Hirn und Hand

by Wolfgang Lehmann Inge Jüling

Dieses Buch hilft Ihnen dabei, mit zunehmendem Alter geistig leistungsfähig zu bleiben, um weiterhin selbstbestimmt zu leben. Denn: Egal, wie alt ein Baum aussieht und egal, wie alt er tatsächlich ist, er kann immer noch aus seinem alten Holz neu austreiben. Genauso hat es jeder auch im höheren Lebensalter selbst in der Hand, Neues zu lernen und so zu trainieren, dass die geistigen Reserven möglichst lange erhalten und genutzt werden können – wollen Sie das? Was wir nicht benutzen, verkümmert. Wenn Sie bereit sind, mit Hirn und Hand aktiv zu sein und durchzuhalten, können Sie Ihre geistige Leistungsfähigkeit mit Hilfe dieses Buches stabilisieren und vielleicht teilweise sogar steigern. Zielgruppen: Alle, die ihre geistige Leistungsfähigkeit im höheren Lebensalter erhalten oder sogar verbessern möchtenAlle, die altersbedingten geistigen Abbauerscheinungen (Demenz) präventiv vorbeugen wollen und Spaß und Freude an geistigen und feinmotorischen Herausforderungen habenAlle, die sich über entwicklungspsychologische Besonderheiten des älteren Menschen informieren oder die privat oder beruflich ältere Menschen / Seniorengruppen betreuen, beschäftigen und fördern möchten Zu den Autoren: Prof. Dr. Wolfgang Lehmann ist Diplompsychologe und externer Mitarbeiter an der Otto-von-Guericke-Universität Magdeburg am Institut für Psychologie. Dr. Inge Jüling ist Diplompsychologin und war als Schulpsychologin tätig. Die Autoren wissen, wovon sie reden: Sie haben jahrelange Erfahrungen mit Senioren, die an Psychologie-Lehrveranstaltungen im Rahmen des Seniorenstudiums "Studieren ab 50" teilnehmen. Das aktive Trainieren hat sich für die Teilnehmer gelohnt, denn sie konnten sich in einigen kognitiven Funktionen sogar verbessern und hatten noch Spaß dabei, Aufgaben zu lösen und Neues zu lernen.

Auch du kannst Lohnsteuer sparen!: Ein Steuerhelfer für den Arbeitnehmer (Fachbücher für die Wirtschaft)

by Herbert Ziob

In meiner Berufsausübung habe ich oft Gelegenheit, Lahnsteuer­ pflichtigen mit Rat und Tat zur Seite zu stehen. Was ich da zu sehen bekomme, ist meist unglaublich. Auch heute noch werden Steuern aus Unkenntnis der möglichen Vorteile und aus mangeln­ der Eigeninitiative überzahlt. Dabei will ja das Finanzamt gar nicht mehr haben, als ihm zusteht. Wenn der Lohnsteuerpflichtige aber erwartet, auf seine Versäumnisse aufmerksam gemacht zu werden, so gibt er sich leider trügerischen Hoffnungen hin. Bei aller Näch­ stenliebe wäre das Finanzamt dazu nicht in der Lage. Es kann doch nur jeder selbst in seinen Geldbeutel hineinsehen und seine finan­ ziellen Belange beurteilen. Und die Kenntnis der persönlichen Ver­ hältnisse ist nun einmal Voraussetzung für jede weitere Überlegung. Ein Einkommensteuerpflichtiger wird seinen Steuerberater fragen, wie er die günstigste Steuerveranlagung erreichen kann. Diese Mög­ lichkeit hat der Lohnsteuerpflichtige in den seltensten Fällen. In Unkenntnis der im Gesetz festgelegten Möglichkeiten versäumt er die Geltendmachung von Werbungskosten, Sonderausgaben oder außergewöhnlichen Belastungen und zahlt mehr Steuern als not­ wendig ist. Ich habe selten einen Fall erlebt, bei dem nicht noch irgendeine Vergünstigung hätte erzielt werden können. In Erkenntnis dieser Tatsachen sollte der Lohnsteuerpflichtige zu einer leider noch viel zu wenig augewandten Selbsthilfe greifen: Er sollte sich mit dem Lohnsteuerrecht vertraut machen. Hier und da geschieht das auch mit gutem Erfolg. Die meisten aber scheuen sich, die umfangreiche Steuerliteratur anzuschaffen, einmal wegen des damit verbundenen wesentlichen Geldaufwandes, zum anderen, weil sie fürchten, damit wenig oder nichts anfangen zu können.

Refine Search

Showing 65,526 through 65,550 of 100,000 results