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Age-related Macular Degeneration: From Clinic to Genes and Back to Patient Management (Advances in Experimental Medicine and Biology #1256)
by Emily Y. Chew Anand SwaroopThis edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.
Age-related Macular Degeneration
by Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide and Alan C. BirdAge-related macular degeneration is the most common cause for the loss of central vision beyond the age of 50 in industrial nations. Triplication of the number of affected patients is expected over the next 25 years. Especially over the last years the standard of knowledge regarding etiology, risk factors, diagnostics and therapy of this retina illness has substantially grown – this will be covered in this up-to-date multi-authored work. Apart from epidemiologically and genetically identified risk factors both the various pathophysiological aspects including the role of the complement system and clinical manifestations including OCT and angiographic characteristics are clearly represented. Furthermore, the different therapeutic approaches are presented and discussed, including proven procedures such as intravitreal anti-VEGF therapy and seeing-aid systems, in addition to the latest and upcoming methods in the area of pharmacology. The volume is well-illustrated and tables and summaries complete the presentation.
Age-related macular degeneration
by Frank G. Holz Daniel Pauleikhoff Richard F. Spaide Alan C. BirdAge-related macular degeneration has become the most common cause of blindness. With population ageing AMD will become an ever more prevalent cause of visual loss unless more effective modes of treatment will be found. Here, an expert panel of experienced clinicians and eminent basic scientists provide for an authoritative review on the pathogenesis, epidemiology and risk factors, diagnostic methods and imaging modalities for age-related macular degeneration. Many photographs and diagrams add to a clear understanding.
Age-Related Macular Degeneration
by Jennifer I. LimThe value of Age-Related Macular Degeneration has stood the test of time, but progress in both basic and clinical ophthalmology has been relentless, mandating the need for an updated book. This second edition focuses on the pathophysiology and the epidemiology of age-related macular degeneration (AMD), the clinical features and management of dry an
Age-Related Macular Degeneration: Current Treatment Concepts (Medical Radiology)
by Robert H. Sagerman GisbertRichard Winfried E. AlbertiAge-related macular degeneration (ARMD) is a frequent disease of the elderly and the most common cause of blindness. Recently, various new treatment options have become available for ARMD. This book, written by recognized experts and including the results of international study groups, provides a comprehensive report on these treatments, documenting their rationale, uses, side-effects, and benefits. It will be of immense value to all with an interest in ARMD.
Age-related Macular Degeneration Diagnosis and Treatment
by Allen C. Ho and Carl D. RegilloAge-Related Macular Degeneration: Diagnosis and Treatment is written by two leading experts from Wills Eye Hospital. Covering the latest therapies and treatments developed in the last few years, this is a concise yet highly illustrated and practical text that guides the clinician through diagnosis and treatment of the leading cause of blindness in older Americans.
Age-Related Macular Degeneration - E-Book
by Weiye LiA consolidated view of a complex disorder, Age-Related Macular Degeneration, summarizes the latest evidence-based studies and translates these advancements into practical, actionable knowledge. This concise resource covers the fundamentals of age-related macular degeneration (AMD) diagnosis and treatment along with a modern definition of the disorder that acknowledges the range of presentations that ophthalmologists see in real practice. Offering practical, clinical guidance in addition to capturing new therapeutic approaches in the pipeline, this book is an essential reference for ophthalmologists, optometrists, and researchers. Takes a concise, yet comprehensive, approach to AMD, covering both basic science and clinical guidance. Features clinical guidelines on the diagnosis and treatment of AMD, including classification, signs/symptoms, imaging, and differential diagnosis in the pre-optical coherence tomography (OCT) and modern OCT eras. Presents up-to-date information on AMD therapies currently in the development pipeline and offers insights for the future of translational research. Explains molecular genetics and pathogenic events of AMD from both basic and clinical perspectives, which may help readers seek promising new therapeutic targets Contains more than 250 images, with multimodal imaging techniques that clearly demonstrate AMD pathophysiology and clinical pathology.
The Age-Well Project: Easy Ways to a Longer, Healthier, Happier Life
by Susan Saunders Annabel Streets'The essential mid-life mum makeover. From fitness to sleep and even your social life, a brilliant new book by two 50-something mothers reveals how to protect your health and happiness' Daily Mail'Educational and informative' Woman's WayDiseases of older age take root decades before symptoms appear. For a longer, happier life, we need to plan ahead - but what exactly should we do?For five years, Annabel Streets and Susan Saunders immersed themselves in the latest science of longevity, radically overhauling their lives and documenting their findings on their popular blog.After reading hundreds of studies and talking to numerous experts, Annabel and Susan have compiled almost 100 short cuts to health in mid and later life, including: how, when and what to eat; the supplements worth taking; when, where and how to exercise; the most useful medical tests; how to avoid health-threatening chemicals; the best methods for keeping the brain sharp; and how to sleep better.The Age-Well Project is an essential handbook for making the second half of your life happy, healthy and disease-free.
Ageing: Lessons from C. elegans (Healthy Ageing and Longevity #5)
by Anders Olsen Matthew S. GillThis book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.
Ageing and Covid-19: Making Sense of a Disrupted World (Social Perspectives on Ageing and Later Life)
by Marvin Formosa Ska Maria 321 Uszczy 324This volume presents a range of research approaches to the exploration of ageing during a pandemic situation. One of the first collections of its kind, it offers an array of studies employing research methodologies that lend themselves to replication in similar contexts by those seeking to understand the effects of epidemics on older people. Thematically organised, it shows how to reconcile qualitative and quantitative approaches, thus rendering them complementary, bringing together studies from around the world to offer an international perspective on ageing as it relates to an unprecedented epidemiological phenomenon. As such, it will appeal to researchers in the field of gerontology, as well as sociologists of medicine and clinicians seeking to understand the disruptive effects of the recent coronavirus outbreak on later life.
Ageing and Covid-19: Making Sense of a Disrupted World (Social Perspectives on Ageing and Later Life)
by Maria ŁuszczyńskaThis volume presents a range of research approaches to the exploration of ageing during a pandemic situation. One of the first collections of its kind, it offers an array of studies employing research methodologies that lend themselves to replication in similar contexts by those seeking to understand the effects of epidemics on older people. Thematically organised, it shows how to reconcile qualitative and quantitative approaches, thus rendering them complementary, bringing together studies from around the world to offer an international perspective on ageing as it relates to an unprecedented epidemiological phenomenon. As such, it will appeal to researchers in the field of gerontology, as well as sociologists of medicine and clinicians seeking to understand the disruptive effects of the recent coronavirus outbreak on later life.
Ageing and Dementia (Journal of Neural Transmission. Supplementa #53)
by K. JellingerAgeing and dementia are closely related conditions. Increasing age of the general population causes increasing incidence of dementing disorders in later life, although cognitive impairment is not necessarily a consequence of advancing age. The book presents the papers of the International Symposium on Ageing and Dementia, October 17–19, 1997 in Graz, where internationally renowned experts in the field of ageing and dementia gave an overview of the current knowledge about the epidemiology, pathomorphology, clinical diagnosis and course of brain ageing processes and related dementing disorders, biochemical markers and imaging procedures for the diagnosis of Alzheimer’s disease and current approaches to a successful treatment of dementia. "... this book will be of interest to clinicians with previous experience of clinical dementia assessements, and to researchers who want a comprehensive update on research areas of dementia with which they are less familiar. It will also be of interest to those following the development of neurotrophe factors for treatment of dementia who need an extensive introduction to the preclinical studies of Cerebrolysin®. The book will be fairly useful as a textbook for clinicians who are learning about clinical dementia assessments for the first time.” Acta Psychiatrica Scandinavica
Ageing and Dementia: Current and Future Concepts (Journal Of Neural Transmission. Supplementa Ser. #62)
by Kurt A. Jellinger Reinhold Schmidt Manfred WindischEpidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Ageing and the Care of Older People in Europe
by Richard HugmanAs the population of all European countries ages rapidly, understanding the phenomenon of ageing and social responses to old age has become a vital contemporary issue. The diverse ways in which old age is seen across Europe are compared and different forms of care for the needs of older people are examined. With the demise of large institutions, and increasing demands on families and on domiciliary care, the question of inter-generational relations is seen as a key element in the future of old age. It is argued that much is to be learned from cross-national comparisons in developing social responses to old age.
Ageing Asia and the Pacific in Changing Times: Implications for Sustainable Development
by John Burgess Subas Dhakal Alan NankervisThis book demonstrates that there are wide-ranging potential challenges in addressing issues associated with ageing populations in both developed and developing countries of the region. This book brings together local, national and regional perspectives on the ageing population and sustainable development nexus in selected countries in the Asia Pacific region. The countries selected in this book include a mix of developed and developing economies that all reflect strong trade, investment and migration linkages. While the Asia Pacific region is forecast to enjoy high growth in the coming decade, a recurring common policy challenge is addressing the ‘demographic time bomb’ posed by ageing populations and workforces (Montague et al., 2017). Consequently, this book focuses on strategic policies and practices of multiple stakeholders, primarily: governments, industry and education systems, together with, the range of aged care services providers – in more effectively addressing these key socio-economic challenges associated with the ageing population for sustainable development.
Ageing, Disability and Spirituality: Addressing the Challenge of Disability in Later Life
by Alan Niven Christine Bryden Christopher Newell Dagmar Ceramidas Eileen Mary Glass Elizabeth Mackinlay John Swinton Kirstin Robertson-Gillam Lawrence Mcnamara Lorna Hallahan Malcolm Goldsmith Matthew Anstey Rosalie Hudson Ruwan PalapathwalaThis collection examines theological and ethical issues of ageing, disability and spirituality, with an emphasis on how ageing affects people who have mental health and developmental disabilities. The book presents ways of moving towards more effective relationships between carers and older people with disabilities; ways in which to connect compassionately and beneficially with the person's spiritual dimension. The contributors highlight the importance of recognizing the personhood of all people regardless of age and of disability, whatever form it takes. They identify factors inherent in personhood and provide ways of affirming and promoting spiritual well-being for older people with disabilities. Valuable reading for practitioners in aged care, healthcare, chaplaincy, social and pastoral care, and diversional therapists, this book will also be of interest to older people, their families and friends.
Ageing, Disability and Spirituality: Addressing the Challenge of Disability in Later Life (PDF)
by Alan Niven Christine Bryden Christopher Newell Dagmar Ceramidas Eileen Mary Glass Elizabeth Mackinlay John Swinton Kirstin Robertson-Gillam Lawrence Mcnamara Lorna Hallahan Malcolm Goldsmith Matthew Anstey Rosalie Hudson Ruwan PalapathwalaThis collection examines theological and ethical issues of ageing, disability and spirituality, with an emphasis on how ageing affects people who have mental health and developmental disabilities. The book presents ways of moving towards more effective relationships between carers and older people with disabilities; ways in which to connect compassionately and beneficially with the person's spiritual dimension. The contributors highlight the importance of recognizing the personhood of all people regardless of age and of disability, whatever form it takes. They identify factors inherent in personhood and provide ways of affirming and promoting spiritual well-being for older people with disabilities. Valuable reading for practitioners in aged care, healthcare, chaplaincy, social and pastoral care, and diversional therapists, this book will also be of interest to older people, their families and friends.
Ageing-Friendly Neighbourhoods in Singapore, Asia-Pacific, Europe and North America: An Annotated Bibliography (SpringerBriefs in Aging)
by Freya C.H. Yu Belinda Yuen Špela Močnik Winston YapThis book brings together the emerging body of work on age-friendly neighbourhoods in Singapore, the Asia-Pacific region, Europe and North America. It begins with an overview chapter on the current state of policy, practice and research on age-friendly neighbourhoods in Singapore. This is followed by an annotated bibliography of published materials on age-friendly neighbourhoods in the above-mentioned countries and regions, encompassing theoretical work and empirical research reported on in journal articles, books and conference proceedings. The annotations for Singapore also map the grey literature, including unpublished dissertations and theses. The aim is to provide a sense of the scope of, issues in, and discourse on age-friendly neighbourhoods, the development of which is increasingly being recognised as a key strategy to support healthy ageing and enhance quality of life in ageing societies.
Ageing, Health And Care (PDF)
by Christina R. VictorThe ageing of the population has enormous implications for the provision of, and access to, health care. Christina Victor's important new textbook provides comprehensive overview of the experiences of older people, chapters on physical health, mental health, disability and lifestyle, a thesis of current policy developments, the key debates on the future health of elders and an international, up-to-date perspective. Written by a leader in the field, the book covers key questions such as the fitness of future older people, the widening inequalities in their health and whether health in old age is related to habits and behaviour in earlier life.
The Ageing Immune System and Health
by Valquiria Bueno Janet M. Lord Thomas A. JacksonThe present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence. The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health.
Ageing in a Nursing Home: Foundations for Care
by Rosalie HudsonSpending the final chapter of your life in a nursing home is considered, by many, a fate worse than death. Others, however, have found that through enlightened, imaginative care even the frailest of lives can flourish. The key to such a transformation is to replace the constricting custodial centres of the past with a more informed, research-based approach. This book is timely, responding to evidence of the urgent need for change described in the Australian Royal Commission into Aged Care Quality and Safety Final Report: Care, Dignity and Respect and its predecessor subtitled Neglect. In this book, the author proposes a model of care that places the whole person at its centre, sidestepping the constraints of a reductionist funding model that focusses on residents' deficits – and the proprietor’s financial gain. Aged care requires a comprehensive research-based guide to fulfil this aim. Narratives are included throughout the book to reinforce the fact that nursing home care is about individual residents and their unique lives. Topics explored in various chapters include:· Ageing in a Changing Community· Social, Gerontological Care· A Palliative Approach· Community Expectations Ageing in a Nursing Home: Foundations for Care takes a realistic approach that draws on contemporary research and narratives from the unique lives of older Australians who, despite their frailty, teach us how to care. Such knowledge informs and influences their future. The book is a resource intended for all who have a stake in the provision of best practice residential aged care, and all who benefit from such care. Its academic appeal will include those who design and teach courses in aged care: gerontology, general practice medicine, nursing, attendant care, allied health, and chaplaincy. Academics and teachers will find useful, well-referenced material for their courses, together with ample scope for researchers.
Ageing in Advanced Industrial States: Riding the Age Waves - Volume 3 (International Studies in Population #8)
by Shripad Tuljapurkar Naohiro Ogawa Anne H. GauthierPopulation growth slowed across the world in the last decades of the 20th century, changing substantially our view of the future. The 21st century is likely to see the end to world population growth and become the century of population aging, marked by low fertility and ever-increasing life expectancy. These trends have prompted many to predict a gloomy future caused by an unprecedented economic burden of population aging. In response, industrialized nations will need to implement effective social and economic policies and programs. This is the final volume in a series of three. The papers included explore many examples and strengthen the basis for effective economic and social policies by investigating the economic, social, and demographic consequences of the transformations in the structures of population and family. These consequences include changes in economic behavior, both in labor and financial markets, and with regard to saving and consumption, and intergenerational transfers of money and care.
Ageing in Australia: Challenges and Opportunities (International Perspectives on Aging #16)
by Kate O’Loughlin Colette Browning Hal KendigThis stimulating volume examines the many faces of Australia’s ageing population, the social and health issues they contend with, and the steps being taken—and many that should be taken—to help ensure a more positive and productive later life. Individual and societal ageing are conceptualized as developmental in nature, socially diverse, and marked by daily life challenges stemming from the country’s economic structures, attitudes, geography, political landscape, and infrastructure. Wide-ranging coverage (e.g., health, inequalities, employment, transportation) assesses options available to older people, and the role of families, employers, service providers, government agencies, and others in promoting or expanding those choices. The book’s double emphasis on challenges in older people’s lives and opportunities for enhancing their quality of life is on clear display as case studies examine policy issues—and propose solutions—in a societal and individual context.Included in the coverage:· Australian developments in ageing: issues and history.· Cultural diversity, health, and ageing.· Indigenous Australians and ageing: responding to diversity in policy and practice.· Enhancing the health and employment participation of older workers.· Housing and the environments of ageing.· Health services and care for older people.The rich examples in Ageing in Australia contain a depth of understanding and evidence for sociologists, gerontologists and psychologists studying ageing, health care professionals providing care to older people, and policy analysts assessing areas for improvement.
Ageing in Times of the COVID-19 Pandemic
by Julia Simonson Jenna Wünsche Clemens Tesch-RömerThis Open Access Book contains reports on the situation of people in the second half of life during the first year of the Covid-19 pandemic. The analyses are based on the German Ageing Survey (DEAS) and they provide insights on four main areas of life: income and work, subjective health and well-being, social support and loneliness as well as societal participation.This book is useful for scientists as well as political actors by directing attention to the risk groups that have been hard hit by the pandemic while also highlighting the resilience and adaptive capacities of many people in the second half of life.
Ageing Issues and Responses in India
by Mala Kapur ShankardassThis book discusses emerging issues concerning ageing in India, describes the multi-layered vulnerabilities of older adults in the context of health care and caregiving, and explores social, legal and economic perspectives. It also analyses the existing policies and programmes intended to address these age-related issues and assesses the importance of preventive geriatrics towards active ageing, as well as the current scenario of institutional care for the elderly in India. Gathering fifteen chapters written by leading researchers in the fields of geriatrics, social work, anthropology, sociology, psychiatry, economics, law and mental health, the book presents the latest findings on ageing-related topics such as elderly health, family change, old age homes, age friendly environments and the role of integrative medicine. Accordingly, it offers a valuable resource for researchers, academics, practitioners and policymakers in the areas of gerontology, demography and sociology, as well as all those interested in the study of ageing populations.