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Preadjusted Edgewise Fixed Orthodontic Appliances: Principles and Practice
by Farhad B. Naini Daljit S. GillExplore the possibilities of preadjusted edgewise appliances in orthodontics with this essential resource Preadjusted Edgewise Fixed Orthodontic Appliances: Principles and Practice comprehensively covers the increasingly popular preadjusted edgewise technique in orthodontics. The book integrates clinical practice and research findings, focusing on the biomechanics and clinical management of patients with preadjusted edgewise appliances. A unique learning resource for specialists and trainees in orthodontics, the book is highly illustrated and broad in scope, covering everything from informed patient consent to clinical techniques to information about how to manage patient malocclusions. Core topics include: A thorough introduction to the principles of treatment planning, orthodontic biomechanics, anchorage, informed patient consent, and the dentolegal aspects of orthodontic treatment An exploration of the preadjusted edgewise appliance, including bracket design, bracket placement, orthodontic bonding and debonding, archwires, mini-implants (TADs) and auxiliaries Comprehensive description of the stages of treatment with preadjusted edgewise appliances, including alignment and levelling, controlled space closure, finishing and retention Information on the management of the major malocclusions (Class II, Class III, anterior open bite, deep overbite and transverse problems) with preadjusted edgewise appliances Perfect for postgraduate dentists undergoing specialist training in orthodontics, specialist practitioners, and hospital consultant orthodontists, Preadjusted Edgewise Fixed Orthodontic Appliances: Principles and Practice will also be useful to dentists with a special interest in orthodontics, orthodontic therapists, and orthodontic nurses who seek a comprehensive manual of the most popular fixed orthodontic appliance technique.
Preadjusted Edgewise Fixed Orthodontic Appliances: Principles and Practice
by Farhad NainiExplore the possibilities of preadjusted edgewise appliances in orthodontics with this essential resource Preadjusted Edgewise Fixed Orthodontic Appliances: Principles and Practice comprehensively covers the increasingly popular preadjusted edgewise technique in orthodontics. The book integrates clinical practice and research findings, focusing on the biomechanics and clinical management of patients with preadjusted edgewise appliances. A unique learning resource for specialists and trainees in orthodontics, the book is highly illustrated and broad in scope, covering everything from informed patient consent to clinical techniques to information about how to manage patient malocclusions. Core topics include: A thorough introduction to the principles of treatment planning, orthodontic biomechanics, anchorage, informed patient consent, and the dentolegal aspects of orthodontic treatment An exploration of the preadjusted edgewise appliance, including bracket design, bracket placement, orthodontic bonding and debonding, archwires, mini-implants (TADs) and auxiliaries Comprehensive description of the stages of treatment with preadjusted edgewise appliances, including alignment and levelling, controlled space closure, finishing and retention Information on the management of the major malocclusions (Class II, Class III, anterior open bite, deep overbite and transverse problems) with preadjusted edgewise appliances Perfect for postgraduate dentists undergoing specialist training in orthodontics, specialist practitioners, and hospital consultant orthodontists, Preadjusted Edgewise Fixed Orthodontic Appliances: Principles and Practice will also be useful to dentists with a special interest in orthodontics, orthodontic therapists, and orthodontic nurses who seek a comprehensive manual of the most popular fixed orthodontic appliance technique.
Precision Cancer Therapies, Immunologic Approaches for the Treatment of Lymphoid Malignancies: From Concept to Practice
by Owen A. O'Connor Stephen M. Ansell John GribbenPresents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.
Precision Cancer Therapies, Immunologic Approaches for the Treatment of Lymphoid Malignancies: From Concept to Practice
by Owen A. O'Connor Stephen M. Ansell John G. GribbenPresents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.
Precision Cancer Therapies, Volume 1: Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice
by Owen A. O'Connor Stephen M. Ansell John F. SeymourTargeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies A thorough compilation of the many scientific breakthroughs in the ongoing development of precision cancer therapies related to lymphoma Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extraordinary advances that have produced such astonishing advances in the disease. The work primarily focuses on how to understand and translate fundamental principles of basic science into information that can be directly applied to patients – hence the subtitle, From Concept to Practice. To aid in readers’ comprehension, the first page of each chapter contains a box entitled ‘Take Home Points’. This short text will highlight the major unique points about the information contained within the chapter. Some of the key topics addressed in the work are as follows: Biological basis of the lymphoid malignancies: fundamental principles of lymphomagenesis and molecular classification of lymphoid malignancies Targeting programmed cell death: principles for understanding the many types of cell death and promising combinations of drugs targeting apoptosis Targeting the PI3K pathway: understanding the intricacies of this complex biology and precisely how targeted drugs can be leveraged therapeutically Targeting the cancer epigenome: pharmacologic features of drugs targeting the epigenome and future prospects for targeting various aspects of epigenetic control Targeting the tumour proteome: understanding the mechanisms of protein degradation in cancer including both older drugs like proteasome inhibitors, and newer PROTAC based approaches Written primarily for scientists and physicians in both the public and private sectors, Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice is a comprehensive reference work for those interested in the growing area of Precision Cancer Therapies. Seamlessly integrating the basic and applied science, this volume will be an indispensable reference for those interested in translating the most important advances in science to innovative novel treatments for patients.
Precision Cancer Therapies, Volume 1: Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice
by Owen A. O’Connor Stephen M. Ansell John F. SeymourTargeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies A thorough compilation of the many scientific breakthroughs in the ongoing development of precision cancer therapies related to lymphoma Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extraordinary advances that have produced such astonishing advances in the disease. The work primarily focuses on how to understand and translate fundamental principles of basic science into information that can be directly applied to patients – hence the subtitle, From Concept to Practice. To aid in readers’ comprehension, the first page of each chapter contains a box entitled ‘Take Home Points’. This short text will highlight the major unique points about the information contained within the chapter. Some of the key topics addressed in the work are as follows: Biological basis of the lymphoid malignancies: fundamental principles of lymphomagenesis and molecular classification of lymphoid malignancies Targeting programmed cell death: principles for understanding the many types of cell death and promising combinations of drugs targeting apoptosis Targeting the PI3K pathway: understanding the intricacies of this complex biology and precisely how targeted drugs can be leveraged therapeutically Targeting the cancer epigenome: pharmacologic features of drugs targeting the epigenome and future prospects for targeting various aspects of epigenetic control Targeting the tumour proteome: understanding the mechanisms of protein degradation in cancer including both older drugs like proteasome inhibitors, and newer PROTAC based approaches Written primarily for scientists and physicians in both the public and private sectors, Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice is a comprehensive reference work for those interested in the growing area of Precision Cancer Therapies. Seamlessly integrating the basic and applied science, this volume will be an indispensable reference for those interested in translating the most important advances in science to innovative novel treatments for patients.
Precision Medicine in Oncology
by Bulent Aydogan James A. RadosevichA FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.
Precision Medicine in Oncology
by James A. Radosevich Bulent AydoganA FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.
Preclinical Development Handbook: ADME and Biopharmaceutical Properties (Pharmaceutical Development Series #3)
by Shayne Cox GadA clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
Preclinical Development Handbook: Toxicology (Pharmaceutical Development Series #4)
by Shayne Cox GadA clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials
by Joy A. Cavagnaro"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials
by Joy A. Cavagnaro"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Predicting Heart Failure: Invasive, Non-Invasive, Machine Learning, and Artificial Intelligence Based Methods
by Issam Bait Bahadur Kishor Kumar Sadasivuni Hassen M. Ouakad Somaya Al-Maadeed Huseyin C. YalcinPREDICTING HEART FAILURE Predicting Heart Failure: Invasive, Non-Invasive, Machine Learning and Artificial Intelligence Based Methods focuses on the mechanics and symptoms of heart failure and various approaches, including conventional and modern techniques to diagnose it. This book also provides a comprehensive but concise guide to all modern cardiological practice, emphasizing practical clinical management in many different contexts. Predicting Heart Failure supplies readers with trustworthy insights into all aspects of heart failure, including essential background information on clinical practice guidelines, in-depth, peer-reviewed articles, and broad coverage of this fast-moving field. Readers will also find: Discussion of the main characteristics of cardiovascular biosensors, along with their open issues for development and application Summary of the difficulties of wireless sensor communication and power transfer, and the utility of artificial intelligence in cardiology Coverage of data mining classification techniques, applied machine learning and advanced methods for estimating HF severity and diagnosing and predicting heart failure Discussion of the risks and issues associated with the remote monitoring system Assessment of the potential applications and future of implantable and wearable devices in heart failure prediction and detection Artificial intelligence in mobile monitoring technologies to provide clinicians with improved treatment options, ultimately easing access to healthcare by all patient populations. Providing the latest research data for the diagnosis and treatment of heart failure, Predicting Heart Failure: Invasive, Non-Invasive, Machine Learning and Artificial Intelligence Based Methods is an excellent resource for nurses, nurse practitioners, physician assistants, medical students, and general practitioners to gain a better understanding of bedside cardiology.
Predicting Heart Failure: Invasive, Non-Invasive, Machine Learning, and Artificial Intelligence Based Methods
by Kishor Kumar Sadasivuni Hassen M. Ouakad Somaya Al-Maadeed Huseyin C. Yalcin Issam Bait BahadurPREDICTING HEART FAILURE Predicting Heart Failure: Invasive, Non-Invasive, Machine Learning and Artificial Intelligence Based Methods focuses on the mechanics and symptoms of heart failure and various approaches, including conventional and modern techniques to diagnose it. This book also provides a comprehensive but concise guide to all modern cardiological practice, emphasizing practical clinical management in many different contexts. Predicting Heart Failure supplies readers with trustworthy insights into all aspects of heart failure, including essential background information on clinical practice guidelines, in-depth, peer-reviewed articles, and broad coverage of this fast-moving field. Readers will also find: Discussion of the main characteristics of cardiovascular biosensors, along with their open issues for development and application Summary of the difficulties of wireless sensor communication and power transfer, and the utility of artificial intelligence in cardiology Coverage of data mining classification techniques, applied machine learning and advanced methods for estimating HF severity and diagnosing and predicting heart failure Discussion of the risks and issues associated with the remote monitoring system Assessment of the potential applications and future of implantable and wearable devices in heart failure prediction and detection Artificial intelligence in mobile monitoring technologies to provide clinicians with improved treatment options, ultimately easing access to healthcare by all patient populations. Providing the latest research data for the diagnosis and treatment of heart failure, Predicting Heart Failure: Invasive, Non-Invasive, Machine Learning and Artificial Intelligence Based Methods is an excellent resource for nurses, nurse practitioners, physician assistants, medical students, and general practitioners to gain a better understanding of bedside cardiology.
Predictive ADMET: Integrated Approaches in Drug Discovery and Development
by Jianling Wang Laszlo UrbanThis book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
Predictive ADMET: Integrated Approaches in Drug Discovery and Development
by Jianling Wang Laszlo UrbanThis book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro / In Vivo Correlations (Wiley Series on Technologies for the Pharmaceutical Industry #11)
by Sean EkinsPractical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro / In Vivo Correlations (Wiley Series on Technologies for the Pharmaceutical Industry #11)
by Sean EkinsPractical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Predictive Toxicology: From Vision to Reality (Methods and Principles in Medicinal Chemistry #64)
by Raimund Mannhold Hugo Kubinyi Gerd FolkersTailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward-looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals.
Predictive Toxicology: From Vision to Reality (Methods and Principles in Medicinal Chemistry #64)
by Raimund Mannhold Hugo Kubinyi Gerd FolkersTailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward-looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals.
Pregnancy and Childbirth: A Cochrane Pocketbook (Wiley Cochrane Series #2)
by G. Justus Hofmeyr James P. Neilson Zarko Alfirevic Caroline A. Crowther Lelia Duley Metin Gulmezoglu Gillian M. Gyte Ellen D. HodnettPregnancy and Childbirth presents the best evidence for the care of pregnant women to doctors, midwives, students and parents. The logical sequence of chapters and the index give quick access to the abstracts of over four hundred Cochrane systematic reviews. The book serves both as a stand-alone reference, and as a companion to locating full reviews on the Cochrane Library. The Cochrane Library is published by John Wiley on behalf of The Cochrane Collaboration. www.thecochranelibrary.com
Pregnancy and Childbirth: A Cochrane Pocketbook (Wiley Cochrane Series)
by G. Justus Hofmeyr James P. Neilson Zarko Alfirevic Caroline A. Crowther Lelia Duley Metin Gulmezoglu Gillian M. Gyte Ellen D. HodnettPregnancy and Childbirth presents the best evidence for the care of pregnant women to doctors, midwives, students and parents. The logical sequence of chapters and the index give quick access to the abstracts of over four hundred Cochrane systematic reviews. The book serves both as a stand-alone reference, and as a companion to locating full reviews on the Cochrane Library. The Cochrane Library is published by John Wiley on behalf of The Cochrane Collaboration. www.thecochranelibrary.com
Pregnancy in the Obese Woman: Clinical Management
by Deborah ConwayObesity presents many challenges to mothers and their unborn babies How can a severely overweight woman prepare for pregnancy? What if she is already pregnant? How do you guide her through an inherently high-risk pregnancy and labor to a successful birth? Pregnancy in the Obese Woman takes the best available evidence on pregnancy and obesity to provide an insightful, practical guide to management in one volume. After a review of the epidemiology and special considerations of prenatal care in obese women of childbearing age, the authors cover: Bariatric surgery Nutrition, exercise, and weight gain in pregnancy Co-morbid conditions Abnormal fetal growth and obstetric complications Operative techniques in obese patients Breastfeeding, contraception, and further pregnancies With obesity on the rise, increasing numbers of pregnancies are being seen in overweight and obese women, which presents a significant challenge to obstetric and other health care providers. Pregnancy in the Obese Woman provides you with the critical information you need to ease your mind and help your patients become contented mothers. Titles of Related Interest Protocols for High-Risk Pregnancies, 5e Queenan, Hobbins and Spong (eds); ISBN 978-1-4051-9650-5 Obstetic Clinical Algorithms: Management and Evidence Norwitz, Belfort, Saade, Miller; ISBN 978-14051-8111-2 Preterm Birth: Prevention and Management Berghella (ed); 978-1-4051-9290-3
Pregnancy in the Obese Woman: Clinical Management
by Deborah ConwayObesity presents many challenges to mothers and their unborn babies How can a severely overweight woman prepare for pregnancy? What if she is already pregnant? How do you guide her through an inherently high-risk pregnancy and labor to a successful birth? Pregnancy in the Obese Woman takes the best available evidence on pregnancy and obesity to provide an insightful, practical guide to management in one volume. After a review of the epidemiology and special considerations of prenatal care in obese women of childbearing age, the authors cover: Bariatric surgery Nutrition, exercise, and weight gain in pregnancy Co-morbid conditions Abnormal fetal growth and obstetric complications Operative techniques in obese patients Breastfeeding, contraception, and further pregnancies With obesity on the rise, increasing numbers of pregnancies are being seen in overweight and obese women, which presents a significant challenge to obstetric and other health care providers. Pregnancy in the Obese Woman provides you with the critical information you need to ease your mind and help your patients become contented mothers. Titles of Related Interest Protocols for High-Risk Pregnancies, 5e Queenan, Hobbins and Spong (eds); ISBN 978-1-4051-9650-5 Obstetic Clinical Algorithms: Management and Evidence Norwitz, Belfort, Saade, Miller; ISBN 978-14051-8111-2 Preterm Birth: Prevention and Management Berghella (ed); 978-1-4051-9290-3
Pregnancy Metabolism, Diabetes and the Fetus (Novartis Foundation Symposia #63)
by Katherine Elliott Maeve O'ConnorThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.