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Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (Human Perspectives in Health Sciences and Technology #2)
by Mariano BizzarriThis volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Appropriation and Invention of Tradition: The East India Company and Hindu Law in Early Colonial Bengal
by Nandini Bhattacharyya PandaThis book, strongly grounded in primary sources, makes an important contribution to the intellectual history of early modern Bengal. It brings to light the complex interpenetration of diverse interests, opinions, and ideologies articulated by various social groups implicated in the process of colonization on the lines of Ranajit Guha's work on property relations in Bengal and Radhika Singha's work on law. There is no comparable work specifically on the subject of Hindu property rights and how these came to be perceived or interpreted in early modern Bengal. The author explores the so-called compendia prepared under British auspices and argues that there was hardly any link between the Smritis and the laws. The latter were determined almost entirely by changing British policy with regard to land revenue and that many of the positive features of Hindu custom like women's rights to property were undermined in the process.
AQA A-level Law For A-level Year 1 and AS (PDF)
by Jacqueline Martin Nicholas PriceExam Board: AQA Level: AS/A-level Subject: Law First Teaching: September 2017 First Exam: June 2018 This title has been approved by AQA Accurately cover the breadth of content in the new 2017 AQA A-level specification with this textbook written by leading Law authors, Jacqueline Martin and Nicholas Price. This engaging and accessible textbook provides coverage of the new AQA A-level Law specification and features authoritative and up-to-date material on the important changes to the law. - Book 1 covers all mandatory units for AS-level and for year 1 of a two-year course. - Important, up-to-date and interesting cases and scenarios highlight key points. - Discussion and activity tasks increase your understanding of more difficult concepts. - Practice questions and 'check your understanding' questions to help your students prepare for their exams. Authors: - Jacqueline Martin LLM has ten years' experience as a practising barrister and has taught law at all levels. - Nicholas Price is an experienced teacher of Law and an A-Level Law textbook author.
AQA A-level Law for Year 1/AS
by Jacqueline Martin Nicholas PriceExam Board: AQALevel: AS/A-levelSubject: LawFirst Teaching: September 2017First Exam: June 2018This title has been approved by AQAAccurately cover the breadth of content in the new 2017 AQA A-level specification with this textbook written by leading Law authors, Jacqueline Martin and Nicholas Price. This engaging and accessible textbook provides coverage of the new AQA A-level Law specification and features authoritative and up-to-date material on the important changes to the law.- Book 1 covers all mandatory units for AS-level and for year 1 of a two-year course.- Important, up-to-date and interesting cases and scenarios highlight key points.- Discussion and activity tasks increase your understanding of more difficult concepts.- Practice questions and 'check your understanding' questions to help your students prepare for their exams.Authors:- Jacqueline Martin LLM has ten years' experience as a practising barrister and has taught law at all levels.- Nicholas Price is an experienced teacher of Law and an A-Level Law textbook author.
AQA A-level Law For Year 2 (PDF)
by Jacqueline Martin Richard Wortley Nicholas PriceExam board: AQA Level: A-level Subject: Law First teaching: September 2017 First exams: Summer 2019 This title has been selected for an AQA approval process. Accurately cover the breadth of content in the new 2017 AQA A-level specification with this textbook written by leading Law authors, Jacqueline Martin, Richard Wortley and Nicholas Price. This engaging and accessible textbook provides coverage of the new AQA A-level Law specification and features authoritative and up-to-date material on the important changes to the law. - Book 2 includes the second section of all mandatory units and both the Human Rights Law and Contract Law optional units. - Important, up-to-date and interesting cases and scenarios highlight key points. - Discussion and activity tasks increase your students' understanding of more difficult concepts. - Practice questions and 'check your understanding' questions to help you prepare for your exams. Authors: - Jacqueline Martin LLM has ten years' experience as a practising barrister and has taught law at all levels. - Richard Wortley has taught law at all levels. He has held a number of examining and assessing roles over the past 25 years. He retired from a management position in a large FE College to work freelance in law teacher support, writing and assessment work. - Nicholas Price is an experienced teacher of Law and an A-Level Law textbook author.
AQA A2 Law Student Unit Guide: Concepts of Law (PDF)
by Peter Darwent Jennifer CurrerPerfect for revision, these guides explain the unit requirements, summarise the content and include specimen questions with graded answers. It has clear guidance on the content of the unit, with topic summaries, knowledge check questions and a quick-reference index.
AQA A2 Law Student Unit Guide: Criminal Law (Offences Against the Person) and Contract Law (PDF)
by Law Yule Peter DarwentPerfect for revision, these guides explain the unit requirements, summarise the content and include specimen questions with graded answers, with clear guidance on the content of the unit, topic summaries, knowledge check questions and a quick-reference index.
AQA A2 Law Sudent Unit Guide: Criminal Law (Offences Against Property and Law of Tort) (PDF)
by Jacqueline Hankins Ian Yule Jennifer CurrerPerfect for revision, these guides explain the unit requirements, summarise the content and include specimen questions with graded answers. It has clear guidance on the content of the unit, with topic summaries, knowledge check questions and a quick-reference index.
AQA A2 Religious Studies: Religion And Ethics And Philosophy Of Religion (PDF)
by Peter Cole Richard GrayUnlock your full potential with this revision guide which provides both the key content you need to know and guidance on how to apply it for better grades My Revision Notes: AQA A2 Religious Studies: Religion and Ethics and Philosophy of Religion helps you to stay motivated and focused during your revision - and gives you the opportunity to practise and refine your skills to achieve the best grade in your exam. - Breaks down all topics into short sections - easy to read and revise from - Exam-style practice questions help confidence with the exam - 'Issues arising' section specifically helps prepare for AQA AS RS AO2 questions - Concise notes, clear layout and colourful features keep you engaged - You can check your learning with the 'test yourself' questions and tick-box design
AQA AS Law Student Unit Guide: The Concept of Liability (PDF)
by Peter Darwent Ian YulePerfect for revision, these guides explain the unit requirements, summarise the content and include specimen questions with graded answers. Contents include: Criminal liability Criminal courts Sentencing Damages Civil courts Contract Negligence nbsp;
AQA AS Law Student Unit Guide: Law Making and the Legal System (PDF)
by Yule Ian Peter DarwentPerfect for revision, these guides explain the unit requirements, summarise the content and include specimen questions with graded answers. Contents include: Parliamentary law making Legislation Judicial precedent The courts system Legal professions Funding of advice and representation
AQA Law A2: Student Book (PDF)
by Wortley Richard Bateman Emma Blundell Guy Smith Peter Wilman JohnAQA Law is the only set of resources to have been developed with, and exclusively endorsed by, AQA, making them the first choice to support the new AQA specification for AS and A2. With a range of truly blended resources, AQA Law offers complete coverage and support through a variety of printed and electronic media.
AQA Law AS: Student Book (2nd edition) (PDF)
by Nicholas Price Richard Wortley Jennifer Currer Peter SmithThis new edition of the bestselling AQA AS Law has been fully updated and revised by expert authors to reflect changes to the law and to the AQA specification.
AQA Law AS: Student Book (1st edition) (PDF)
by Wortley Richard Currer Jennifer Price Nicholas Smith PeterAQA Law is the only set of resources to have been developed with, and exclusively endorsed by, AQA, making them the first choice to support the new AQA specification for AS and A2. With a range of truly blended resources, AQA Law offers complete coverage and support through a variety of printed and electronic media.
AQA Law for A2 (5th edition) (PDF)
by Jacqueline Martin Denis LancerThe most up-to-date AQA A2 Law textbook - from the number 1 A-Level Law author - that will prepare your for your exams. This engaging and accessible textbook provides complete coverage of the whole AQA A2 specification. From the leading law author, it is comprehensive, authoritative and updated with important changes to the law. Now includes: - Fully updated with the latest changes to criminal, tort and contract law - Important and interesting cases and scenarios to highlight key points - Activities to increase your students'understanding of more difficult concepts - Examination practice, past-paper questions and self-test questions to help your students prepare for their exams
AQA Law for AS (4th edition) (PDF)
by Jacqueline MartinAQA Law for AS, 4th edition covers all the necessary AQA AS level topics in a clear order and in accessible language. This edition has been revised to incorporate recent changes to the law, including full details of the new Supreme Court. There are illustrations, cartoons and activities throughout to clarify difficult concepts and help readers remember the key information in revision. A new 'Exam Tips' feature will ensure that students are better prepared than ever for the exam.
AQA Law for AS (5th edition) (PDF)
by Denis Lanser Jacqueline MartinCover all the AQA AS level topics clearly with this textbook written by the leading A level Law author. Up to date, accessible and now with more past papers to prepare students for their exams, AQA Law for AS, Fifth Edition, is matched to the course. Jacqueline Martin has helped hundreds of thousands be successful in studying law. She has ensured that this book addresses every topic in detail. Reflect recent changes in the legal system, in areas such as sentencing, tort of negligence and contract law , Clarify difficult concepts and help students remember the key information with illustrations, cartoons and activities,. Help your students to practise with activities through. Prepare your students for their exams with the new Exam Tips feature plus exam questions based on recent AQA papers.
AQA Law for AS (6th edition) (PDF)
by Jacqueline MartinCover all the AQA AS level topics clearly with this textbook written by the leading A level Law author.
AQA Law GCSE: Student Book (PDF)
by Jones Alan Page TraceyThe one-stop shop for all your Law requirements Developed with and exclusively endorsed by AQA, this is the only book to provide teachers with the complete reassurance that they have everything they need to deliver AQA's new GCSE Law specification.
Aquaculture, Innovation and Social Transformation (The International Library of Environmental, Agricultural and Food Ethics #17)
by Keith Culver David CastleKeith Culver and David Castle Introduction Aquaculture is at the leading edge of a surprisingly polarized debate about the way we produce our food. According to the United Nations Food and Agriculture Organization, aquaculture production has increased 8. 8% per year since 1970, far surpassing productivity gains in terrestrial meat production at 2. 8% in the same period (FAO 2007). Like the ‘green revolution’ before it, the ‘blue revolution’ in aquaculture promises rapidly increased productivity through technology-driven - tensi?cation of aquaculture animal and plant production (Costa-Pierce 2002; The Economist 2003). Proponents of further aquaculture development emphasize aq- culture’s ancient origins and potential to contribute to global food security d- ing an unprecedented collapse in global ?sheries (World Fish Center; Meyers and Worm 2003; Worm et al. 2006). For them, technology-driven intensi?cation is an - dinary and unremarkable extension of past practice. Opponents counter with images of marine and freshwater environments devastated by intensive aquaculture pr- tices producing unsustainable and unhealthy food products. They view the promised revolutionasascam,nothingmorethanclever marketingbypro?t-hungry ?shfa- ers looking for ways to distract the public from the real harms done by aquaculture. The stark contrast between proponents and opponents of modern aquaculture recalls decades of disputes about intensive terrestrial plant and animal agriculture, disputes whose vigor shows that the debate is about much more than food production (Ruse and Castle 2002).
Aquaculture Perspective of Multi-Use Sites in the Open Ocean: The Untapped Potential for Marine Resources in the Anthropocene
by Bela H. Buck Richard LanganThis book is open access under a CC BY 4.0 license.This volume addresses the potential for combining large-scale marine aquaculture of macroalgae, molluscs, crustaceans, and finfish, with offshore structures, primarily those associated with energy production, such as wind turbines and oil-drilling platforms. The volume offers a comprehensive overview and includes chapters on policy, science, engineering, and economic aspects to make this concept a reality. The compilation of chapters authored by internationally recognized researchers across the globe addresses the theoretical and practical aspects of multi-use, and presents case studies of research, development, and demonstration-scale installations in the US and EU.
Aquinas: Political Writings (PDF)
by R. W. Dyson Thomas AquinasThomas Aquinas (1225-74) is a massive figure in the history of western thought and of the Catholic church. In this major addition to the Cambridge Texts series Robert Dyson (whose modern rendition of Augustine's City of God has already been widely acclaimed) has chosen texts by Aquinas that show his development of a Christian version of the philosophy of Aristotle, its contrast with the Augustinian thought that had coloured so much political thinking in the previous eight centuries, and St Thomas's views as to the purpose of government, constitutions, and the relations between secular and ecclesiastical power. Property, slavery, and usury are fully covered, as are St Thomas's celebrated and influential writings on law. The translations are extremely accessible and the whole is supported by all of the usual series features designed to assist the student reader, including brief biographies, notes for further reading and a concise critical introduction.
Aquinas and the Market: Toward a Humane Economy
by Mary L. HirschfeldEconomists investigate the workings of markets and tend to set ethical questions aside. Theologians often dismiss economics, losing insights into the influence of market incentives on individual behavior. Mary L. Hirschfeld bridges this gap by showing how a humane economy can lead to the good life as outlined in the thought of St. Thomas Aquinas.
Aquinas on the Beginning and End of Human Life
by Fabrizio AmeriniThough often invoked by pro-life supporters, Thomas Aquinas in fact held that human life begins after conception, not at the moment of union. But in following the twists and turns of Aquinas’ thinking about the beginning and end of human life, Fabrizio Amerini reaches a nuanced interpretation that will unsettle both sides in the abortion debate.