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Anesthesia of the Upper Limb: A State of the Art Guide
by Fernando Alemanno Mario Bosco Aldo BarbatiLoco-regional anesthesia offers evident advantages in almost all branches of surgery since it couples perfect anesthesia with prolonged postoperative analgesia. Furthermore, new drugs and techniques are ensuring constant progress, and in the past decade the advent of ultrasound-guided regional anesthesia has played a key role by allowing direct visualization of all anatomic structures involved in regional blocks. In conjunction with electrostimulation, it has significantly increased the success rate of loco-regional anesthesia.This book, comprising 16 chapters and more than 140 color illustrations, provides detailed coverage of the techniques currently employed in upper limb anesthesia. It opens by reviewing the anatomy of the brachial plexus and the topographic anatomy as it is of the utmost importance for anesthesiologists to have a deep knowledge of anatomy despite the assistance offered by new tools. Subsequently the various techniques, including supraclavicular, infraclavicular, and axillary brachial plexus blocks, peripheral blocks, and intravenous regional anesthesia, are discussed in depth, with due attention to potential complications. Up-to-date information is also provided on the role of ultrasound, and an entire chapter is devoted to ultrasound-guided interscalene and supraclavicular blocks. The book will be an invaluable learning tool for students and an excellent aid in daily clinical practice for anesthesiologists.
Gastrointestinal Regulatory Peptides (Handbook of Experimental Pharmacology #106)
by A. Alemayehu B. Amiranoff D. L. Barber S. R. Bloom J. Calam R. E. Carraway Feng Chen C. S. Chew C. C. Chou J. M. Conlon A. Couvineau E. Ekblad T. S. Gaginella J. J. Galligan J. R. Grider R. Hakanson P. Kitabgi M. Laburthe Y. P. Loh M. S. O'Dorisio S. M. O'Grady R. K. Pearson R. J. Playford E. Rozengurt F. Sundler I. ZacharyThe most comprehensive and conceptual one-volume treatment of this field available and the first to emphasize the cellular and molecular aspects of gut peptide biology. Authored by an array of internationally distinguished scientists, it deals with issues of peptide localization and biosynthesis in gastrointestinal cells, mechanisms of peptide release and inactivation and the nature of peptide receptors. The breadth and readability make it an invaluable reference source for scientists in all disciplines interested in any aspect of brain-gut peptides.
Statistical Topics in Health Economics and Outcomes Research (Chapman & Hall/CRC Biostatistics Series)
by Demissie Alemayehu Joseph C. Cappelleri Birol Emir Kelly H. ZouWith ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to request for HEOR evidence, in addition to data from clinical trials, to inform decisions about patient access to new treatment options. While there is a great deal of literature on HEOR, there is a need for a volume that presents a coherent and unified review of the major issues that arise in application, especially from a statistical perspective. Statistical Topics in Health Economics and Outcomes Research fulfils that need by presenting an overview of the key analytical issues and best practice. Special attention is paid to key assumptions and other salient features of statistical methods customarily used in the area, and appropriate and relatively comprehensive references are made to emerging trends. The content of the book is purposefully designed to be accessible to readers with basic quantitative backgrounds, while providing an in-depth coverage of relatively complex statistical issues. The book will make a very useful reference for researchers in the pharmaceutical industry, academia, and research institutions involved with HEOR studies. The targeted readers may include statisticians, data scientists, epidemiologists, outcomes researchers, health economists, and healthcare policy and decision-makers.
Statistical Topics in Health Economics and Outcomes Research (Chapman & Hall/CRC Biostatistics Series)
by Demissie Alemayehu Joseph C. Cappelleri Birol Emir Pstat Kelly H. ZouWith ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to request for HEOR evidence, in addition to data from clinical trials, to inform decisions about patient access to new treatment options. While there is a great deal of literature on HEOR, there is a need for a volume that presents a coherent and unified review of the major issues that arise in application, especially from a statistical perspective. Statistical Topics in Health Economics and Outcomes Research fulfils that need by presenting an overview of the key analytical issues and best practice. Special attention is paid to key assumptions and other salient features of statistical methods customarily used in the area, and appropriate and relatively comprehensive references are made to emerging trends. The content of the book is purposefully designed to be accessible to readers with basic quantitative backgrounds, while providing an in-depth coverage of relatively complex statistical issues. The book will make a very useful reference for researchers in the pharmaceutical industry, academia, and research institutions involved with HEOR studies. The targeted readers may include statisticians, data scientists, epidemiologists, outcomes researchers, health economists, and healthcare policy and decision-makers.
Interface between Regulation and Statistics in Drug Development (Chapman & Hall/CRC Biostatistics Series)
by Demissie Alemayehu Birol Emir Michael GaffneyWith the critical role of statistics in the design, conduct, analysis and reporting of clinical trials or observational studies intended for regulatory purposes, numerous guidelines have been issued by regulatory authorities around the world focusing on statistical issues related to drug development. However, the available literature on this important topic is sporadic, and often not readily accessible to drug developers or regulatory personnel. This book provides a systematic exposition of the interplay between the two disciplines, including emerging themes pertaining to the acceleration of the development of pharmaceutical medicines to serve patients with unmet needs. Features: Regulatory and statistical interactions throughout the drug development continuum The critical role of the statistician in relation to the changing regulatory and healthcare landscapes Statistical issues that commonly arise in the course of drug development and regulatory interactions Trending topics in drug development, with emphasis on current regulatory thinking and the associated challenges and opportunities The book is designed to be accessible to readers with an intermediate knowledge of statistics, and can be a useful resource to statisticians, medical researchers, and regulatory personnel in drug development, as well as graduate students in the health sciences. The authors’ decades of experience in the pharmaceutical industry and academia, and extensive regulatory experience, comes through in the many examples throughout the book.
Interface between Regulation and Statistics in Drug Development (Chapman & Hall/CRC Biostatistics Series)
by Demissie Alemayehu Birol Emir Michael GaffneyWith the critical role of statistics in the design, conduct, analysis and reporting of clinical trials or observational studies intended for regulatory purposes, numerous guidelines have been issued by regulatory authorities around the world focusing on statistical issues related to drug development. However, the available literature on this important topic is sporadic, and often not readily accessible to drug developers or regulatory personnel. This book provides a systematic exposition of the interplay between the two disciplines, including emerging themes pertaining to the acceleration of the development of pharmaceutical medicines to serve patients with unmet needs. Features: Regulatory and statistical interactions throughout the drug development continuum The critical role of the statistician in relation to the changing regulatory and healthcare landscapes Statistical issues that commonly arise in the course of drug development and regulatory interactions Trending topics in drug development, with emphasis on current regulatory thinking and the associated challenges and opportunities The book is designed to be accessible to readers with an intermediate knowledge of statistics, and can be a useful resource to statisticians, medical researchers, and regulatory personnel in drug development, as well as graduate students in the health sciences. The authors’ decades of experience in the pharmaceutical industry and academia, and extensive regulatory experience, comes through in the many examples throughout the book.
Emerging Technologies During the Era of COVID-19 Pandemic (Studies in Systems, Decision and Control #348)
by Mostafa Al-Emran Gonçalo Marques Ibrahim Arpaci Mohammed A. Al-SharafiThis book tackles the recent research directions in using the newly emerged technologies during the era of COVID-19 pandemic. It mainly focuses on using emerging technologies and their impact on health care, education, and society. It also provides insights into the current challenges and constraints in using technologies during the era of COVID-19 pandemic and exposes new opportunities for future research in the domain.
Natural Hazard Mitigation Policy: Implementation, Organizational Choice, and Contextual Dynamics (Environmental Hazards)
by Daniel J. Alesch Lucy A. Arendt William J. PetakThe negative consequences of natural hazard events are staggering and growing. Governments are acting to increase community resilience, reduce losses, and facilitate recovery, but these actions do not always yield anticipated consequences. This book is a compelling interdisciplinary analysis of California’s efforts to ensure that acute care hospitals survive earthquakes and continue to function in the aftermath. The book weaves together several threads essential to understanding the effectiveness of public policies intended to reduce the consequences of natural hazard events: public policy design and administration, the hazard mitigation investment decision made by targeted organizations, and contextual dynamics. "A terrific study of shortfalls in the implementation of risk-reduction policy -- highly readable, full of insights, and very policy relevant." Peter J. May, Donald R. Matthews Distinguished Professor of American Politics, University of Washington, Seattle USA "This is an exceptional book by three of the leading hazard mitigation researchers and must reading for both scholars and practitioners in the field." William A. Anderson, National Research Council, National Academy of Sciences.
Tiefe Hirnstimulation: Ein Ratgeber für Betroffene bei Morbus Parkinson
by François Alesch Iris KaiserDas Buch befasst sich mit sämtlichen Aspekten der tiefen Hirnstimulation. Einerseits wird medizinisches, psychologisches und technisches Hintergrundwissen verständlich vermittelt, andererseits auf alltägliche Probleme eingegangen, die auf den ersten Blick zu simpel erscheinen, um hinterfragt zu werden. Das Buch richtet sich in erster Linie an Patienten und Angehörige, aber auch an Neurologen, Psychiater, Psychologen und Angehörige anderer Gesundheitsberufe, die sich über die tiefe Hirnstimulation und deren Anwendungsgebiete informieren wollen.
Versorgung von Patienten mit geistiger und Mehrfachbehinderung: Auswirkungen und Probleme im Zeitalter des DRG-Abrechnungssystems
by Viktoria AleshchenkovaDie Autorin untersucht Anreizwirkungen des DRG-Abrechnungssystems auf die medizinische Versorgung von Personen mit geistiger und Mehrfachbehinderung. Im Krankenhausbereich erwiesen sich eine mangelhafte Pflegeversorgung, Wissensdefizite in der Behindertenmedizin und ein defizitärer Informationsaustausch zwischen den Akteuren als relevante Faktoren. Die Qualität der medizinischen Versorgung der Zielgruppe im Krankenhaus hat sich nach der DRG-Einführung zwar nicht verschlechtert. Gleichzeitig weisen die empirischen Daten aber auf eine versteckte Patientenselektion und Leistungsverlagerung der Krankenhäuser auf. Es sollten rechtzeitig geeignete Maßnahmen getroffen werden, um die Versorgungsprobleme zu entschärfen und gemeinwirtschaftlichen Kosten zu senken.
Pharmaceutical Regulatory Environment: Challenges and Opportunities in the Gulf Region
by Reem K. Al-Essa Mohammed Al-Rubaie Stuart Walker Sam SalekThis book compares national and centralised procedure practices and key performance metrics, including current approval times, review practices and pharmacovigilance standards, in the seven Gulf States. Opportunities for an improved regulatory system are identified, which, if fully implemented, could have a significant impact on patients’ access to new medicines.The Persian Gulf represents the next growth market for the global biopharmaceutical industry but to date there has been limited information about the regulatory review processes employed in these countries. A thorough examination of the strategies currently being implemented by the Gulf States is considered critical to the future regulatory environment in this region.Pharmaceutical Regulatory Environment: Challenges & Opportunities in the Gulf Region is a must read for those interested in pharmaceutical regulation in the Gulf region.
Increase your Brainability—and Reduce your Risk of Dementia
by Charles Alessi Larry W. Chambers Muir GrayDreaded by many people as an inevitable part of normal aging, Dementia has displaced Cancer as the most feared health problem. Cancer continues to be a serious condition, but it is often curable, and almost always treatable. In contrast, the fear of dementia is complicated by the fear of ageing, and by muddled thinking about its relationship with Alzheimer's disease. Yet, there is no reason to be disheartened. Ever-evolving scientific evidence means that we can be increasingly optimistic about the future, and on-going research shows that the problems we dread- dementia, disability and dependency- can be controlled. By taking steps to limit damage to the brain caused by stress, sleep problems, and inactivity throughout our lives, it is more than possible to substantially reduce your risk of dementia. Equally, a loss of physical fitness (which starts long before old age) is preventable. Based on research from the Optimal Ageing Programme, and full of practical, evidence-based advice on managing the major risk factors underpinning dementia, this book will inspire readers to fight back against the modern environment and negative societal attitudes. Through simple but effective lifestyle changes that anyone can make, everyone can take positive action to increase their brainability. It is never too late to change your life, reduce your risk, and live better for longer.
Dynamiek van het menselijk bindweefsel: Functie, beschadiging en herstel
by Jeroen Alessie Karl Jacobs Jan Jaap de MorreeDit boek biedt een functionele beschrijving van verschillende typen bindweefsels en vertaalt die naar kennis over lichamelijke belasting, beschadiging en herstel. Het is bedoeld voor studenten fysiotherapie, bewegingstherapie, manuele therapie, ergonomie en kinesitherapie aan hogescholen en universiteiten. Ook voor professionals is het een handig naslagwerk. De eerste versie van Dynamiek van het menselijk bindweefsel verscheen 30 jaar geleden. Deze zevende druk is inhoudelijk ingrijpend gewijzigd, op basis van nieuwe inzichten en recent onderzoek naar bindweefsel. En dan met name op het gebied van de anatomie en de rol van het fasciale systeem als kracht-geleidend en proprioceptief systeem. Hoofdstuk 2 gaat nu in op de embryologische ontwikkeling van bindweefsel en hoofdstuk 9 staat volledig in het teken van de diverse functies van het fasciale systeem. Ook zijn nieuwe foto’s toegevoegd ter illustratie van spier-, pees-, en fasciaweefsel. Dynamiek van het menselijk bindweefsel is een goed aanknopingspunt om de juiste vorm van therapie te kunnen bepalen. Het laatste hoofdstuk helpt daar expliciet bij, daarin staan overwegingen om de therapeutische interventie te ondersteunen. Dynamiek van het menselijk bindweefsel heeft een nieuwe auteursteam. Jeroen Alessie is hogeschooldocent fysiotherapie. Ook is hij is coauteur van paramedische studieboeken. Karl Jacobs is voormalig fysiotherapeut, studeerde Functional and Clinical Anatomy en is als anatoom verbonden aan het Amsterdam UMC. Beide auteurs zijn ervaren sprekers op congressen en betrokken bij diverse bij- en nascholingen.
Physical Activity Across the Lifespan: Prevention and Treatment for Health and Well-Being (Issues in Children's and Families' Lives #12)
by Aleta L. Meyer and Thomas P. GullottaThe statistics are disturbing: steadily rising numbers of sedentary overweight children and obese teens, and a generation looking at a shorter life expectancy than their parents’. But while it may be obvious that physical fitness benefits both the mind and body, a growing research base is supplying evidence of why this is so, and how these benefits may be reproduced in greater numbers.Physical Activity Across the Lifespan makes a clear, scientific case for exercise, sports, and an active lifestyle in preventing illness and establishing lifetime health habits at both the individual and the population levels. The book focuses on key aspects of physical/mental well-being—weight, mood, and self-regulation—and the role of physical activity in public health and school-based interventions targeting these areas. Contributors review definitional and measurement issues salient to understanding what physical activity is, to analyzing benefits of participation, and to implementing effective interventions. Also addressed are limitations of current research, steps needed to continue building the field, and emerging therapeutic possibilities for activity, such as the role of rough and tumble play in preventing ADHD. Included in the coverage:Physical activity, cognition, and school performance.The influence of social and built environments on physical activity in middle-aged and older adults.Preventing and treating obesity through physical activity.Physical activity in preventing drug use and treating chemical dependence.Antidepressant properties of physical activity.Schools as a foundation for physical activity and an active lifestyle.Physical activity as an adjunct or booster to existing interventions.Physical Activity Across the Lifespan is an innovative text for researchers and practitioners in various disciplines including health promotion/disease prevention, child and school psychology, education, health psychology, and public health, as well as program developers and policymakers in these areas.
Math Everywhere: Deterministic and Stochastic Modelling in Biomedicine, Economics and Industry
by G. Aletti Martin Burger Alessandra Micheletti Daniela MoraleThese proceedings report on the conference "Math Everywhere", celebrating the 60th birthday of the mathematician Vincenzo Capasso. The conference promoted ideas Capasso has pursued and shared the open atmosphere he is known for. Topic sections include: Deterministic and Stochastic Systems. Mathematical Problems in Biology, Medicine and Ecology. Mathematical Problems in Industry and Economics. The broad spectrum of contributions to this volume demonstrates the truth of its title: Math is Everywhere, indeed.
Attrition in the Pharmaceutical Industry: Reasons, Implications, and Pathways Forward
by Alexander Alex C. John Harris Dennis A. SmithWith a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency. • Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attrition• Tackles a problem that adds billions of dollars to drug development programs and health care costs• Guides discovery and development scientists through R&D stages, teaching requirements and reasons why drugs can fail• Discusses potential ways forward utilizing new approaches and opportunities to reduce attrition
Attrition in the Pharmaceutical Industry: Reasons, Implications, and Pathways Forward
by Alexander Alex C. John Harris Dennis A. SmithWith a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency. • Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attrition• Tackles a problem that adds billions of dollars to drug development programs and health care costs• Guides discovery and development scientists through R&D stages, teaching requirements and reasons why drugs can fail• Discusses potential ways forward utilizing new approaches and opportunities to reduce attrition
Medical Imaging Informatics
by Alex A.T. Bui Ricky K. TairaMedical Imaging Informatics provides an overview of this growing discipline, which stems from an intersection of biomedical informatics, medical imaging, computer science and medicine. Supporting two complementary views, this volume explores the fundamental technologies and algorithms that comprise this field, as well as the application of medical imaging informatics to subsequently improve healthcare research. Clearly written in a four part structure, this introduction follows natural healthcare processes, illustrating the roles of data collection and standardization, context extraction and modeling, and medical decision making tools and applications. Medical Imaging Informatics identifies core concepts within the field, explores research challenges that drive development, and includes current state-of-the-art methods and strategies.
Clinical Trial Optimization Using R (Chapman & Hall/CRC Biostatistics Series)
by Alex Dmitrienko; Erik PulkstenisClinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies. It provides the clinical researcher with a powerful evaluation paradigm, as well as supportive R tools, to evaluate and select among simultaneous competing designs or analysis options. It is applicable broadly to statisticians and other quantitative clinical trialists, who have an interest in optimizing clinical trials, clinical trial programs, or associated analytics and decision making. This book presents in depth the Clinical Scenario Evaluation (CSE) framework, and discusses optimization strategies, including the quantitative assessment of tradeoffs. A variety of common development challenges are evaluated as case studies, and used to show how this framework both simplifies and optimizes strategy selection. Specific settings include optimizing adaptive designs, multiplicity and subgroup analysis strategies, and overall development decision-making criteria around Go/No-Go. After this book, the reader will be equipped to extend the CSE framework to their particular development challenges as well.
Rehabilitation Engineering: Principles and Practice (Rehabilitation Science in Practice Series)
by Alex Mihailidis and Roger SmithThis book will provide an overview of the rehabilitation engineering field, including key concepts that are required to provide a solid foundation about the discipline. It will present these concepts through a mix of basic and applied knowledge from rehabilitation engineering research and practice. It's written as an introductory text in order to provide access to the field by those without previous experience or background in the field.These concepts will include those related to engineering and health that are necessary to understand the application of rehabilitation engineering to support human function.
Publics and their health: Historical problems and perspectives (Social Histories of Medicine #45)
by Alex Mold, Peder Clark and Hannah J. ElizabethThe COVID-19 pandemic has resulted in a renewed interest in the relationship between public health authorities and the public. Particular attention has been paid to ‘problem publics’ who do not follow health advice. This is not a new issue. As the chapters in this collection demonstrate, the designation of certain groups or populations as problem publics has long been a part of health policy and practice. By exploring the creation and management of these problem publics in a range of time periods and geographical locations, the collection sheds light on what is both specific and particular. For health authorities, publics themselves were often thought to pose problems, because of their behaviour, identity or location. But publics could and did resist this framing. There were, and continue to be, many problems with seeing publics as problems.
Rest: Why You Get More Done When You Work Less
by Alex Soojung-Kim PangIn our 24-7 global economy, rest feels like a luxury at best and a weakness at worst. We see work and rest as competitors - but what if they're actually partners in a productive, balanced life? Blending rigorous scientific research with examples of writers, painters and thinkers - from Darwin to Stephen King - Silicon Valley futurist and business consultant Alex Soojung-Kim Pang exposes how we've underestimated the power of rest for our success. Though it's as natural as breathing, it's also a skill we can all learn to boost our creativity and productivity.Full of tips for upping our downtime, from sleep to hobbies to vacation, Rest is a new roadmap for finding renewed energy and inspiration, and getting more done.
Pharmacology of Asthma (Handbook of Experimental Pharmacology #98)
by A. G. Alexander P. J. Barnes K. F. Chung R. J. Flower L. G. Garland R. G. Goldie S. T. Holgate A. B. Kay A. Laitinen L. A. Laitinen K. M. Lulich C. P. Page J. W. Paterson R. Pauwels C.G.A. Persson I. W. Rodger M. Schmitz-Schumann R. C. Small S. F. Smith A. Szczeklik C. Virchow J. W. WilsonThis volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has changed dramatically in recent years, and much of this new information is brought together in this volume written by inter nationally recognised authorities. The aim of the book is to review in depth the changing concepts of inflammatory processes in asthma and to discuss the implications for research of this common chronic disease. Many of the advances in and future therapy our understanding of asthma have originated from a pharmacological approach, and this volume highlights the promising new options for pharma cological intervention. It is hoped this book will be invaluable for research scientists and clinic ians involved in asthma research and will be a major reference resource for chest physicians and those involved in the development of novel pharmaceu tical entities. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN and A. LAmNEN. With 10 Figures ...................... 1 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 1 . . . . . . . . . . . . . . . B. Methods to Investigate the Pathology of Human Asthma ............ 1 C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks ........................... 2 I. Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 4 . . . . . . . . . . . . . . II. Eosinophils ............................................... 7 III. Neutrophils.............................................. 10 D. Bronchial Epithelial Inflammation During an Asthma Attack. . . . . .. . 10 E. Epithelial Regeneration .... . . . . . . . . . . . . . . . . . . . . . . .. . . 12 . . . . . . . . .
Ekƶem · Dermatitis Pruritus · Prurigo · Strophulus Neurodermitis·Seborrhoisches Ekƶem (Handbuch der Haut- und Geschlechtskrankheiten #A / 6 / 1)
by A. Alexander C. Kreibich P. G. Unna F. Winkler M. WinklerDieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.
Gewerbehygiene und Gewerbekrankheiten
by Alexander Alexander Adolf Gottstein Arthur Schloßmann Ludwig TelekyDieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.