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Matrix Pathobiology and Angiogenesis (Biology of Extracellular Matrix #12)
by Evangelia Papadimitriou Constantinos M. MikelisIn the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability. This book aims to provide the reader with an overview of the various roles of the ECM during angiogenesis and covers its important role for the maintenance of vascular integrity, capillary and arterial morphogenesis, as well as lymphangiogenesis. Furthermore, aspects of regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions are discussed. In addition, the reader will learn more about different approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions. Comprehensive and cutting-edge, Matrix Pathobiology and Angiogenesis is a valuable resource for experienced researchers and early career scientist alike, who are interested in in learning more about this exciting and developing field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Matron at Last
by Evelyn Prentis'When do you have a bath?' I asked Mrs Turgoose. 'I hope you're not suggesting that I don't look after meself properly,' she said crossly. 'There was a woman who used to use it, but that was because she was a bit stuck up. She soon went off the idea when it started to get cold.'After working as a nurse for thirty years, Evelyn left the hospital to become a full-time Matron at The Lodge - a home for elderly ladies of reduced circumstances. Evelyn was nothing like the matrons she had known and feared in the past. In spite of broken nights and hot dinners left to get cold, Mrs Peters with her temper and Mrs Harrison with her 24-hour piano playing, her new role offered a chance to make a difference to her ladies' lives. Even though it did mean she was on call twenty-four hours a day, this is Evelyn's funny and affectionate memoir of her years - at last! - as a Matron.
Matron in Charge: The Life Of A 1960s Nurse
by Evelyn Prentis'She should never have kept the business going after her husband died. Running a betting shop is no job for a woman. Especially when she's got bad legs.'After a short stay at hospital herself, Evelyn Prentis wondered what was in store for her when she returned to work. From the door-slamming Miss Cromwell to Mrs Silver's shoplifting and Mrs May coming over all queer, being Matron in charge of the Lodge was rarely straightforward.So when her ladies became unusually united in their grumbling about newest resident Ivy, the woman who'd kept the betting shop on the High Street, Evelyn was ready for all hell to break loose.But instead, with openness and kindness, Ivy won people over and even started bringing them together. Suddenly, being in charge of the Lodge was no trouble at all ...
Matron Knows Best: More True Stories Of A 1960s Nhs Nurse
by Joan WoodcockJoan Woodcock always dreamed of becoming a nurse. And in 1966 the dream came true. From her very first day as a naive 16 year old cadet, standing nervously outside the matron's office, this is Joan's story of an eventful career spanning over forty years in NHS nursing.Working on hospital wards, casualty units and out in the community, as well as stints in a prison and a police unit dealing with sexual assault, Joan has seen it all. In this moving memoir she gives an honest, revealing account of a challenging, unpredictable and ultimately rewarding life in nursing.From an early encounter with a horrific axe injury to the patient who swallowed their suppositories, to daily dealings with difficult patients and all kinds of bodily fluids, Joan shares memories of laughter and tragedy, and of the now defunct matron system that at one time instilled nurses with such high standards of professionalism and patient care.
The Matter of Death: Space, Place and Materiality
by J. Hockey C. Komaromy K. WoodthorpeThis collection opens up spaces where lives end, bodies are disposed of and memories generated: hospitals, hospices, care homes, coroners' courts, funeral premises, cemeteries, roadsides, the spirit world. Using material culture studies it illuminates the ways human beings make meaningful the challenges of death, dying and bereavement.
Matter of Mind: A Neurologist's View of Brain-Behavior Relationships
by Kenneth M. HeilmanMost of what has been learned about how the brain mediates behavior comes from experiments of nature where a stroke or other damage to the brain produces changes in a person's behavior. In Matter of Mind, one of the leading figures in behavioral and cognitive neurology uses patient vignettes and other examples from his rich professional life to show just how much knowledge about brain functions such as reading, writing, language, control of emotions, skilled movement, perception, attention, and motivation has been gained from the study of patients with diseases of or damage to the brain. No knowledge of neurology or neuroscience is required to understand the book, which is intended for neurological patients and their families. It will also be of interest to professionals who study the brain or treat patients with brain damage including neuropsychologists, neurologists, neuroscientists, psychologists, physiatrists, speech pathologists, occupational and physical therapists, and their students and trainees.
The Matter of the Heart: A History of the Heart in Eleven Operations
by Thomas Morris'Thrilling... The “dizzying” story of heart surgery is every bit as important as that of the nuclear, computer or rocket ages. And now it has been given the history it deserves' James McConnachie, Sunday TimesFor thousands of years the human heart remained the deepest of mysteries; both home to the soul and an organ too complex to touch, let alone operate on. Then, in the late nineteenth century, medics began going where no one had dared go before. In eleven landmark operations, Thomas Morris tells us stories of triumph, reckless bravery, swaggering arrogance, jealousy and rivalry, and incredible ingenuity, from the trail-blazing ‘blue baby’ procedure to the first human heart transplant. The Matter of the Heart gives us a view over the surgeon’s shoulder, showing us the heart’s inner workings and failings. It describes both a human story and a history of risk-taking that has ultimately saved millions of lives.
Matters of Life and Death: Perspectives on Public Health, Molecular Biology, Cancer, and the Prospects for the Human Race
by John CairnsCancer has become the scourge of the twentieth century. It was always part of the human condition, but until recently it was not a common cause of death because most people died from the infectious diseases. Now that so many of us will live long enough to develop cancer, we need to learn as much about it as we can. This requires some understanding of molecular biology. John Cairns has made significant contributions to cancer research, molecular biology, and virology. He believes that it is possible to explain what is known about cancer and about molecular biology in terms that are easily understood by people with little or no scientific training. In this fascinating book, he explores the revolution in public health, the origins and principles of molecular biology, and our emerging understanding of the causes of cancer. Finally, he discusses how these developments are likely to affect future generations. As Cairns points out, the last two hundred years have altered our life expectations beyond all recognition. Even in the less developed nations of the world, people are starting to believe that everyone ought to be able to live into old age and be protected from the major causes of premature death. This change in our expectations is one of the major benefits of technology and the biological sciences. But the resulting explosion in the human population ultimately threatens everything we have gained by scientific progress.
Matters of Life and Death: Perspectives on Public Health, Molecular Biology, Cancer, and the Prospects for the Human Race
by John CairnsCancer has become the scourge of the twentieth century. It was always part of the human condition, but until recently it was not a common cause of death because most people died from the infectious diseases. Now that so many of us will live long enough to develop cancer, we need to learn as much about it as we can. This requires some understanding of molecular biology. John Cairns has made significant contributions to cancer research, molecular biology, and virology. He believes that it is possible to explain what is known about cancer and about molecular biology in terms that are easily understood by people with little or no scientific training. In this fascinating book, he explores the revolution in public health, the origins and principles of molecular biology, and our emerging understanding of the causes of cancer. Finally, he discusses how these developments are likely to affect future generations. As Cairns points out, the last two hundred years have altered our life expectations beyond all recognition. Even in the less developed nations of the world, people are starting to believe that everyone ought to be able to live into old age and be protected from the major causes of premature death. This change in our expectations is one of the major benefits of technology and the biological sciences. But the resulting explosion in the human population ultimately threatens everything we have gained by scientific progress.
Matters of Life and Death: Key Writings
by Iona HeathIn this extraordinary book, Iona Heath draws on her experience as a general practitioner to select and comment on a collection of passages concerning death and dying, and to consider the essential nature of general practice. In Ways of Dying Heath illuminates the process for professionals and lay readers, and stimulates consideration of approaches to improved care at end of life. Her renowned work The Mystery of General Practice (which has been unavailable for some time), considers the complex character of this field, its core values and changing roles. The two extended essays cover important issues on the role of the healthcare professional in the care of the dying, the idea of life and death, and the essential nature of general practice. Matters of Life and Death offers inspiration for all doctors, especially those with an interest in medical humanities. It will also be of great interest to general readers interested in end of life matters, and the nature and art of medicine.
Matters of Life and Death: Key Writings
by Iona HeathIn this extraordinary book, Iona Heath draws on her experience as a general practitioner to select and comment on a collection of passages concerning death and dying, and to consider the essential nature of general practice. In Ways of Dying Heath illuminates the process for professionals and lay readers, and stimulates consideration of approaches to improved care at end of life. Her renowned work The Mystery of General Practice (which has been unavailable for some time), considers the complex character of this field, its core values and changing roles. The two extended essays cover important issues on the role of the healthcare professional in the care of the dying, the idea of life and death, and the essential nature of general practice. Matters of Life and Death offers inspiration for all doctors, especially those with an interest in medical humanities. It will also be of great interest to general readers interested in end of life matters, and the nature and art of medicine.
Matters of Life and Death: Making Moral Theory Work in Medical Ethics and the Law
by David OrentlicherPhilosophical debates over the fundamental principles that should guide life-and-death medical decisions usually occur at a considerable remove from the tough, real-world choices made in hospital rooms, courthouses, and legislatures. David Orentlicher seeks to change that, drawing on his extensive experience in both medicine and law to address the translation of moral principle into practice--a move that itself generates important moral concerns. Orentlicher uses controversial life-and-death issues as case studies for evaluating three models for translating principle into practice. Physician-assisted suicide illustrates the application of ''generally valid rules,'' a model that provides predictability and simplicity and, more importantly, avoids the personal biases that influence case-by-case judgments. The author then takes up the debate over forcing pregnant women to accept treatments to save their fetuses. He uses this issue to weigh the ''avoidance of perverse incentives,'' an approach to translation that follows principles hesitantly for fear of generating unintended results. And third, Orentlicher considers the denial of life-sustaining treatment on grounds of medical futility in his evaluation of the ''tragic choices'' model, which hides difficult life-and-death choices in order to prevent paralyzing social conflict. Matters of Life and Death is a rich and stimulating contribution to bioethics and law. It is the first book to examine closely the broad problems of translating principle into practice. And by analyzing specific controversies along the way, it develops original insights likely to provoke both moral philosophers and those working on thorny issues of life and death.
Matters of Life and Death: Making Moral Theory Work in Medical Ethics and the Law
by David OrentlicherPhilosophical debates over the fundamental principles that should guide life-and-death medical decisions usually occur at a considerable remove from the tough, real-world choices made in hospital rooms, courthouses, and legislatures. David Orentlicher seeks to change that, drawing on his extensive experience in both medicine and law to address the translation of moral principle into practice--a move that itself generates important moral concerns. Orentlicher uses controversial life-and-death issues as case studies for evaluating three models for translating principle into practice. Physician-assisted suicide illustrates the application of ''generally valid rules,'' a model that provides predictability and simplicity and, more importantly, avoids the personal biases that influence case-by-case judgments. The author then takes up the debate over forcing pregnant women to accept treatments to save their fetuses. He uses this issue to weigh the ''avoidance of perverse incentives,'' an approach to translation that follows principles hesitantly for fear of generating unintended results. And third, Orentlicher considers the denial of life-sustaining treatment on grounds of medical futility in his evaluation of the ''tragic choices'' model, which hides difficult life-and-death choices in order to prevent paralyzing social conflict. Matters of Life and Death is a rich and stimulating contribution to bioethics and law. It is the first book to examine closely the broad problems of translating principle into practice. And by analyzing specific controversies along the way, it develops original insights likely to provoke both moral philosophers and those working on thorny issues of life and death.
Matters of Life and Death: Making Moral Theory Work in Medical Ethics and the Law
by David OrentlicherPhilosophical debates over the fundamental principles that should guide life-and-death medical decisions usually occur at a considerable remove from the tough, real-world choices made in hospital rooms, courthouses, and legislatures. David Orentlicher seeks to change that, drawing on his extensive experience in both medicine and law to address the translation of moral principle into practice--a move that itself generates important moral concerns. Orentlicher uses controversial life-and-death issues as case studies for evaluating three models for translating principle into practice. Physician-assisted suicide illustrates the application of ''generally valid rules,'' a model that provides predictability and simplicity and, more importantly, avoids the personal biases that influence case-by-case judgments. The author then takes up the debate over forcing pregnant women to accept treatments to save their fetuses. He uses this issue to weigh the ''avoidance of perverse incentives,'' an approach to translation that follows principles hesitantly for fear of generating unintended results. And third, Orentlicher considers the denial of life-sustaining treatment on grounds of medical futility in his evaluation of the ''tragic choices'' model, which hides difficult life-and-death choices in order to prevent paralyzing social conflict. Matters of Life and Death is a rich and stimulating contribution to bioethics and law. It is the first book to examine closely the broad problems of translating principle into practice. And by analyzing specific controversies along the way, it develops original insights likely to provoke both moral philosophers and those working on thorny issues of life and death.
Matthews Model of Clinical Reasoning: A Systematic Guide to Occupation-Based Evaluation and Intervention Planning
by Laurie Knis-MatthewsThe Matthews Model of Clinical Reasoning (MMCR) provides occupational therapy practitioners with a systematic approach to develop their clinical reasoning skills during the evaluation and intervention process when collaborating with persons served across multiple practice locations. The three core constructs of person, environment, and occupation lay the foundation for practitioners to compartmentalize information from selected evaluations, determine relevant intervention priorities, implement occupation-based intervention plans, and interpret successful outcomes. This book, influenced by these constructs, the practice framework, and accreditation standards for academic preparedness, provides the reader with the foundational information on how to apply the core constructs using a MMCR systematic approach for evaluation and intervention. Within the chapters are a variety of instructional methods, interviews with practitioners of various levels of experience, and case study examples. Clinical reasoning guidesheets are presented to assist the reader to follow the MMCR clinical reasoning process in terms of evaluation findings, application of frame of reference (FOR)/practice models, intervention strategies, and documentation. Occupational therapy students and practitioners will be provided with the foundational skills to systematically think about and apply the steps of the clinical reasoning process, starting with a person’s evaluation through the completion of the intervention plan.
Matthews Model of Clinical Reasoning: A Systematic Guide to Occupation-Based Evaluation and Intervention Planning
The Matthews Model of Clinical Reasoning (MMCR) provides occupational therapy practitioners with a systematic approach to develop their clinical reasoning skills during the evaluation and intervention process when collaborating with persons served across multiple practice locations. The three core constructs of person, environment, and occupation lay the foundation for practitioners to compartmentalize information from selected evaluations, determine relevant intervention priorities, implement occupation-based intervention plans, and interpret successful outcomes. This book, influenced by these constructs, the practice framework, and accreditation standards for academic preparedness, provides the reader with the foundational information on how to apply the core constructs using a MMCR systematic approach for evaluation and intervention. Within the chapters are a variety of instructional methods, interviews with practitioners of various levels of experience, and case study examples. Clinical reasoning guidesheets are presented to assist the reader to follow the MMCR clinical reasoning process in terms of evaluation findings, application of frame of reference (FOR)/practice models, intervention strategies, and documentation. Occupational therapy students and practitioners will be provided with the foundational skills to systematically think about and apply the steps of the clinical reasoning process, starting with a person’s evaluation through the completion of the intervention plan.
Maturation Phenomenon in Cerebral Ischemia: Proceedings of the Satellite Symposium of the XIth International Congress of Neuropathology Tokyo, September 11–12, 1990
by IgorKlatzo T. Kuroiwa T. Kirino UmeoItoIt has been well recognized that following an ischemic insult many nerve cells of the brain are not killed outright, but may suffer a "delayed neuronal death" or even recover. This led to the concept of "maturation phenomenon" with its main implication that the maturation of ischemic lesions may provide a "window of opportunity" i.e. a period of time when the injury to neuronal elements is still reversible, and during which an application of proper therapeutic measures might be successful. The symposium on Maturation Phenomenon in Cerebral Ischemia was the first international meeting focussed primarily on this subject and the resulting publication contains presentations and discussionsby prominent researchers engaged in this field. This book should stimulate further research on potential of brain tissue for recovery, and particularly with regard to a functional recovery of neurons suffering from chronic ischemic injury.
Maturation Phenomenon in Cerebral Ischemia II: Neuronal Recovery and Plasticity
by IgorKlatzo ToshihikoKuroiwa TakaakiKirino UmeoItoMany nerve cells of the brain which are not killed outright may suffer delayed death or recovery after ischemic insult. This fact has led to the concept of "maturation phenomenon" of neuronal injuries. Since the 1st International Symposium on Maturation Phenomenon in 1990, new developments, particularly in molecular biology, have been rapidly bringing new information about molecular nature and mechanisms of cell death. This book contains the presentations of the 2nd International Symposium held in Tokyo in April 1996. The latest developments in maturation phenomenon and the present status of investigation are described and further stimulation of research in this field is provided.
Maturation Phenomenon in Cerebral Ischemia III: Defensive Mechanisms Versus Apoptosis Neuronal Recovery and Protection in Cerebral Infarction
by Umeo Ito Cesare Fieschi Francesco Orzi Toshihiko Kuroiwa Igor KlatzoThe Maturation Phenomenon, described by Ito et al. in 1975 [3) on the basis of his to logical observations in the hippocampus as well as other portions of the cerebral hemisphere, refers to the hours or days of delay in the development of pathological changes in various parameters of ischemic injury following the restoration of blood flow to the ischemic brain. There is a direct relationship between the intensity of ischemic insult and the speed and rate of maturation of ischemic injury, a lesser intensity being associated with slower and less severe development of the lesions. The delayed neuronal death of CAl pyramidal cells of the hippocampus [8) is a classic example. In the cerebral cortex, with increasing intensity of the ischemic insult, the maturation phenomenon of ischemic injuries intensifies, seamlessly, from less exten sive to more extensive disseminated selective neuronal necrosis (DSNN), and then further to cerebral infarction upon reaching a critical threshold [1,2,4,6,7). We also have found that following ischemic insults just under the threshold level required to induce infarction, only disseminated selective neuronal necrosis (DSNN) progresses, while following ischemic insults at the threshold level, initially only DSNN develops, followed by the evolution of a gradually enlarging infarcted focus [5, 7). The reporting of this phenomenon boosted research in the field, as it became evi dent that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention.
Maturation Phenomenon in Cerebral Ischemia IV: Apoptosis and/or Necrosis, Neuronal Recovery vs. Death, and Protection Against Infarction
by Igor Klatzo, Toshihiko Kuroiwa, Victor L. Marcheselli, Umeo Ito, Nicolas G. BazanThe maturation phenomenon, first described by Ito et al. in 1975, refers to postischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CA1 pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evident that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention. Since then a growing number of studies have improved our knowledge on mechanisms of cell death and recovery. This volume contains the presentations of the 4th international symposium, held in New Orleans in October/November 1999, grouped in sections covering apoptosis and/or necrosis, neuronal recovery vs. death, and protection against infarction. It outlines the present status of investigations and provides further stimulation for research in this field.
Maturation Phenomenon in Cerebral Ischemia V: Fifth International Workshop April 28–May 1, 2002 Banff, Alberta, Canada
by Alastair M. Buchan Umeo Ito Fred Colbourne Toshihiko Kuroiwa Igor KlatzoThe Maturation Phenomenon, first described by Ito et al. in 1975, refers to post ischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CAl pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evi dent that ischemic damage is not a sudden event but a process potentially suscep tible to therapeutic intervention. In September 1990, Ito and collaborators organized the First International Sym posium on "Maturation Phenomenon in Cerebral Ischemia" which was held in To kyo, Japan. The Second Symposium was organized in Tokyo, Japan in March/April 1996. The Third Symposium was held in Pozzilli, Italy in April 1998 and the Fourth Symposium was held in New Orleans, Louisiana, USA in October/Novem ber 1999. This book contains the presentations of the Fifth International Workshop on Maturation Phenomenon in Cerebral Ischemia held at the Rimrock Resort Ho tel in Banff, Alberta, Canada on April 28-May 1, 2002. It outlines the present sta tus of investigations and provides further stimulation for research in this field. The Maturation Phenomenon represents a continuing struggle for survival be tween the acceleration of tissue or neuronal death and the activation of defense mechanisms leading to neuronal recovery. The elucidation of these mechanisms is important for developing the ability to manipulate them during a long-lasting "therapeutic window".
The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs (The Maudsley Prescribing Guidelines Series)
by Mark Horowitz David TaylorThe Maudsley® Deprescribing Guidelines Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more. Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so. The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment. This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts). Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as: Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse. Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.
The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs (The Maudsley Prescribing Guidelines Series)
by Mark Horowitz David TaylorThe Maudsley® Deprescribing Guidelines Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more. Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so. The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment. This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts). Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as: Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse. Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.
The Maudsley Guidelines on Advanced Prescribing in Psychosis
by Paul Morrison David M. Taylor Phillip McGuireA guide to treating psychosis that provides information on drug options and side-effects in order to allow for weighing treatment options knowledgably The Maudsley Guidelines on Advanced Prescribing in Psychosis offers a resource that puts the focus on the need to treat the individual needs of a patient. The authors – noted experts on the topic – offer an alternative to the one-size-fits-all treatment of psychosis and shows how to build psychiatrist and patient relationships that will lead to effective individual treatment plans. The book provides up-to-date data and information about commonly used anti-psychotic drugs and drugs used in bipolar disorder. The text weighs both the upsides and downsides of each pharmaceutical presented, and helps prescribers and patients weigh the costs and benefits of various options to reach an appropriate treatment plan. The authors highlight the treatment at a population level and the systems in which individual treatments take places. This important resource: Facilitates the tailoring of an appropriate treatment plan for clients manifesting signs of psychosis Offers a comparative strategy that helps gauge the suitability of one treatment plan over another Provides at-hand data and information about commonly used anti-psychotic drugs Includes an understanding of the origins and side-effects of each drug presented The Maudsley Guidelines on Advanced Prescribing in Psychosis offers psychiatrists and other mental health practitioners an essential guide for treating psychosis on an individualized level.
The Maudsley Handbook of Practical Psychiatry
by Gareth Owen, Simon Wessely and Robin MurrayThe Maudsley Handbook of Practical Psychiatry has long served trainees in psychiatry, presenting them with practical and essential advice. This new edition of the orange book provides guidance on the psychiatric and neuropsychiatric examination and interviewing of adults and childrennot just as a central skill, but as the basis for reaching a diagnosis, formulation and defining a treatment plan. It covers special interview situations, such as dealing with specific patient reactions, and other special problems, for example, conducting a complicated assessment in cases of self-harm. The book concludes with important legal issues and is supported by helpful appendices for ready-reference. As with previous editions, this sixth edition has been revised and rewritten with the full and active involvement of a group of consultant psychiatrists and trainees, making it a highly relevant and practical handbook for all psychiatrists whether learning or refreshing their skills.