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Adrenergic Mechanisms in Myocardial Ischemia

by JohnRoss GerdHeusch

Adrenergic Receptor Protocols (Methods in Molecular Biology #126)

by Curtis A. Machida

Adrenergic receptors are important modulators in the sympathetic c- trol of various metabolic processes in the central and peripheral nervous s- tems. These receptors are localized at multiple sites throughout the central nervous system (CNS) and serve as important regulators of CNS-mediated behavior and neural functions, including mood, memory, neuroendocrine c- trol, and stimulation of autonomic function. Adrenergic Receptor Protocols consists of 35 chapters dealing with va- ous aspects of adrenergic receptor analyses, including the use of genetic, RNA, protein expression, transactivator, second messenger, immunocytochemical, electrophysiological, transgenic, and in situ hybridization approaches. This volume details the use of various methods to examine the adrenergic receptor system, using aspects of the genetic flow of information as a guide (DNA? RNA ? transactivator ? protein expression ? second messenger analyses ? cellular analyses ? transgenic whole animal approaches). Adrenergic Receptor Protocols displays step-by-step methods for s- cessful replication of experimental procedures, and would be useful for both experienced investigators and newcomers in the field, including those beg- ning graduate study or undergoing postdoctoral training. The Notes section contained in each chapter provides valuable troubleshooting guides to help develop working protocols for your laboratory. With Adrenergic Receptor Protocols, it has been my intent to develop a comprehensive collection of modern molecular methods for analyzing adrenergic receptors. I would like to thank the many chapter authors for their contributions.

The Adrenergic Receptors: In the 21st Century (The Receptors)

by Dianne M. Perez

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction

by J. Brachmann A. Schömig

Adrenoceptors (Handbook of Experimental Pharmacology #285)

by Jillian G. Baker Martin C. Michel Roger J. Summers

Adrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field.

Adrenocortical Carcinoma: Basic Science and Clinical Concepts

by Gary D. Hammer and Tobias Else

We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists. We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.

The Adrenocortical Hormones: Their Origin · Chemistry Physiology and Pharmacology (Handbook of Experimental Pharmacology #14 / 2)

by Helen W. Deane M. S. Goldstein F. G. Hofmann Betty L. Rubin R. Levine E. H. Sobel

2 Vol. 3: Hormones, Psychology and Behavior (1952). A range of interests was covered in respect to the influence of glucocorticoids on behavioral responses, as well as to the glucocorticoid status in various behavioral states and disorders. Vol. 4: Anterior Pituitary Secretion and Hormonal Influence in Water Metab­ olism (1952). Book II of this volume contains considerable detail about the various relationships of the glucocorticoids to other hormones with respect to their influence on water and electrolyte excretion. Vol. 5: Bioassay of Anterior Pituitary and Adrenal Cortical Hormones (1953). An entire section was devoted to chemical measurement and bioassay of gluco­ corticoids in blood and urine, with a comparison of these methods. Vol. 7: Synthesis and Metabolism of Adrenal Cortical Steroids (1954). Additional data on the intermediary metabolism and biosynthesis of the glucocorticoids are available in this volume and supplement the review by HECHTER and PINCUS listed below (cf. DoRFMAN, Chapter 3, Part 1 of this Handbuch volume). Vol. 8: The Human Adrenal Cortex (1955). A very wide range of articles was presented which extended from studies of the adrenal cortex itself to studies of adrenal function in a variety of human somatic and psychological stressful situa­ tions, and clinical conditions. DEBono, R. C., and N. ALTSZULER: Insulin Hypersensitivity and Physiological Insulin Antagonists. Physiol. Rev. 38: 389-445 (1958). The subject of this review went beyond glucocorticoids, but the influence and role of these steroids in relation to insulin, other hormones and carbohydrate metabolism was thoroughly handled.

Adrenomedullin in Cardiovascular Disease (Basic Science for the Cardiologist #19)

by Toshio Nishikimi

Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease.

Adrian Mole: The Prostrate Years (The\adrian Mole Ser. #8)

by Sue Townsend None

'Effortlessly hilarious. Brilliant satire and tragedy' The TimesCelebrate Adrian Mole's 50th Birthday with this new edition of THE EIGHTH and FINAL BOOK in his diaries, as Adrian continues to struggle with his love life, endures a painfully awkward school play and contemplates the unsettling prospect of applying genital poultice.--------------------------- Sunday 1st July NO SMOKING DAY A momentous day! Smoking in a public place or place of work is forbidden in England. Though if you a lunatic, a prisoner, an MP or a member of the Royal Family you are exempt. Adrian Mole is thirty-nine and a quarter. He lives in the country in a semi-detached converted pigsty with his wife Daisy and their daughter. His parents George and Pauline live in the adjoining pigsty. But all is not well. The secondhand bookshop in which Adrian works is threatened with closure. The spark has fizzled out of his marriage. His mother is threatening to write her autobiography (A Girl Called Shit). And Adrian's nightly trips to the lavatory have become alarmingly frequent . . . 'A tour de force by a comic genius and if it isn't the best book published this year, I'll eat my bookshelf' Daily Mail, Books of the Year 'Hilarious. Comic gold' Sunday Times 'The funniest person in the world' Caitlin Moran

ADS/ADHS Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung: Fortschritte in der Diagnose und Therapie


Auf dem Weg zu em em besseren Verstandnis von ADS/ADHS Die Beitrage des vorliegenden Buches sind dos Ergebnis einer Konferenz iiber ADS/ADHS (Auf­ merksomkeitsdefizit-/HyperoktivitatsstQrung), die EndeAugust 2002 in Homburg stattgefunden hot. An dieser Konferenz nohmen auf der einen Seite Wissenschoft/er, Arzte und Psychologen und auf deronderen Seire Elrern und Lehrer teil. Obwohl nicht aile Veranstoltungen gemeinsom durchgefiihrt wurden, bestond fiir aile Gruppen Transporenz. Dadurch entsrand zwischen den Experten und den Eltem bzw. den Lehrem ein neues Verstandnis. Unser gemeinsomes liel ist eine kritische Sicht der Forschungsergebnisse und eine verbesserte praktische Versorgung von Kin­ dem mit ADS/ADHS. Dos Themo ADSIADHS ist in den vergangenen zehn Jahren mit einer uniiberschaubaren Fiille van Forschungsbemiihungen untersucht und mit einer eben solchen Fiille von - tei/weise widerspruchlichen - Erkenntnissen uberflutet worden. Die hier vorliegenden Beitrage konnen und wollen keinen Anspruch auf Vol/stondigkeit erheben. Sie vermitteln al/erdings einen kom­ pakten Uberblick uberdie wichtigsten Dimensionen, wie PhOnomenologie, fpidemiologie, Urso­ chenforschung sowie medikomentose und psychotherapeutische Therapie.

Adult Acute Lymphocytic Leukemia: Biology and Treatment (Contemporary Hematology)

by Anjali S. Advani and Hillard M. Lazarus

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.

Adult ADHD: Diagnostic Assessment and Treatment

by J. J. Kooij

This updated volume provides a clinical based overview of the assessment and treatment of ADHD in adults by a clinical researcher with extensive experience. Its practical focus allows each chapter to answer common questions encountered within clinical practice. Differential diagnosis of ADHD is also discussed in relation to comorbidity with bipolar disorder, borderline personality disorder, chronic fatigue syndrome, and chronic delayed sleep phase. Adult ADHD: Diagnostic Assessment and Treatment, fourth edition aims to help readers identify ADHD effectively and put in place suitable treatments. The book is relevant for psychiatrists, neurologists, and healthcare professionals involved in the diagnosis and treatment of adult ADHD.

Adult ADHD: Diagnostic Assessment and Treatment

by J.J. Sandra Kooij

Adult ADHD: Diagnostic Assessment and Treatment, Third Edition covers not only diagnostic assessment, but also comorbidity patterns as well as differential diagnosis of ADHD with for example bipolar disorder and borderline personality disorder. The symptom overlap and misdiagnosis of chronic fatigue syndrome in girls and women with the inattentive subtype of ADHD, ADD is explored. The chronic delayed sleep phase syndrome associated with ADHD based on disturbances in the circadian rhythm, and the possible consequences for general health (obesity, diabetes, cardiovascular diseases and cancer) are discussed. There are sections on ADHD and intelligence, criminality, sexuality, dyslexia and autism. Adult ADHD can be treated effectively but as yet the disorder is not always recognised by professionals and this book aims to help correct this.Diagnostic tools are included, such as the structured Diagnostic Interview for Adult ADHD (DIVA), and an ultra-short and somewhat longer screening tool, all based on the DSM-IV criteria for ADHD. Treatment options cover psychoeducation and motivation and individual and group coaching; long-acting stimulants and other new drugs for treating ADHD; use of melatonin to treat the delayed sleep-phase disorder. Useful information is included on the setting up and organisation of a department for adult ADHD with a multidisciplinary team. References, websites and useful international addresses have all been updated. Adult ADHD: Diagnostic Assessment and Treatment, Third Edition is intended for students, junior doctors/residents, psychologists, psychiatrists, other mental healthcare professionals and interested parties and provides a quick overview of the current state of the science and of the methods used in diagnosis and treatment.Adult ADHD: Diagnostic Assessment and Treatment, Third Edition was originally published by Pearson Assessment and Information BV, The Netherlands.

Adult and Pediatric Neuromodulation

by Jason P. Gilleran Seth A. Alpert

This text reviews the anatomy and physiology of neuromodulation for treatment of various pathology of the human body, with specific emphasis on sacral neuromodulation for bladder and bowel dysfunction in the adult and pediatric populations. In addition to historical overview of the various methods of neuromodulation, present day applications will be discussed as well as possible future directions for use. Adult and Pediatric Neuromodulation will be of great value to medical professionals who are interested in the use of neuromodulation as a possible therapy option for their patients, particularly when other traditional or medical management options have failed. Each chapter is written by experts in the topic of various modalities of neuromodulation.

Adult and Pluripotent Stem Cells: Potential for Regenerative Medicine of the Cardiovascular System

by Jürgen Hescheler Erhard Hofer

There is hardly an area of research developing so quickly and raising so many promises as stem cell research. Adult, embryonic and recently available induced pluripotent stem cells not only foster our understanding of differentiation of endo-, ecto- and mesodermal lineages to all organs of the body, but foremost nourish the hope that cells grown in culture can be used for regeneration of diseased organs such as the heart damaged by myocardial infarction. This book focuses on perspectives of stem cells for regenerative therapy of cardiovascular diseases. Based on the EC consortium INELPY, it reviews the field and disseminates major outcomes of this project. Thus it introduces the reader to this fascinating area of research and incorporates very recent findings interesting to the expert, spanning the field from bench to bedside. The compilation of contributions is unique as there is yet no similar comprehensive overview combining stem cell research with preclinical and clinical evaluation as well as engineering of tissue patches for transplantation. As such it will be an invaluable source of information for all researchers in the stem cell and tissue regeneration field including bioengineers as well as for all clinicians interested in regenerative therapies, especially for ischemic cardiomyopathies.

Adult Aural Rehabilitation

by Denzil N. Brooks

'Man's need for communication with his fellow man is possibly his greatest need and the fulfilment of his other needs and desires is largely dependent upon, or at the last greatly facilitated by, his ability to satisfy this basic one.' Louise Tracy Defective hearing disrupts human communication. It gives rise to anxiety, frustration, stress, isolation, loss of self-esteem, even loss of livelihood for the individual with a reduced capacity to receive and interpret sound. Because we live in families and communities, the effects of hearing loss are not restricted to the impaired individual. Those who associate with that person, especially those who are very close, are affected and prone to many of the same emotions and stresses. From the earliest times man has sought for remedies for hearing loss. Incantations, infusions, cuppings and bleedings, all have been advo­ cated and, with the rare, serendipitous exception, have been equally ineffective. The only real assistance for countless generations was to cup the hand behind the ear and ask the speaker to raise their voice.

Adult CNS Radiation Oncology: Principles and Practice

by Eric L. Chang Paul D. Brown Simon S. Lo Arjun Sahgal John H. Suh

This book elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.

Adult Cognition: An Experimental Psychology of Human Aging (Springer Series in Cognitive Development)

by Timothy A. Salthouse

For some time now, the study of cognitive development has been far and away the most active discipline within developmental psychology. Although there would be much disagreement as to the exact proportion of papers published in developmental journals that could be considered cognitive, 50% seems like a conservative estimate. Hence, a series of scholarly books to be devoted to work in cognitive development is especially appropriate at this time. The Springer Series in Cognitive Development contains two basic types of books, namely, edited collections of original chapters by several authors, and original volumes written by one author or a small group of authors. The flagship for the Springer Series is a serial publication of the "advances" type, carrying the subtitle Progress in Cognitive Development Research. Volumes in the Progress sequence are strongly thematic, in that each is limited to some well-defined domain of cognitive-developmental research (e. g. , logical and mathematical development, semantic development). All Progress volumes are edited collections. Editors of such books, upon consultation with the Series Editor, may elect to have their works published either as contributions to the Progress sequence or as separate volumes. All books written by one author or a small group of authors will be published as separate volumes within the series. A fairly broad definition of cognitive development is being used in the selection of books for this series.

Adult Congenital Heart Disease: A Practical Guide

by Michael A. Gatzoulis Lorna Swan Judith Therrien George A. Pantely

Congenital heart disease with its worldwide incidence of 1% is the most common inborn defect. Increasingly, patients are living into adulthood, with ongoing congenital heart and other medical needs. Sadly, only a small minority have specialist follow-up. However, all patients see their family doctor and may also seek advice from other health professionals. This practical guide with its straightforward a,b,c approach is written for those professionals. Special features of this book: • Introduces the principles of congenital heart disease and tells you whom and when to refer for specialist care • Discusses common congenital heart lesions in a practical, easy-to-follow way, with an emphasis on diagnosis and management issues • Includes an extensive chapter on 'Pregnancy and Contraception' (by Philip J. Steer), essential both for family planning and for managing safely the pregnant woman with congenital heart disease • Includes chapters on non-cardiac surgery and lifestyle issues such as work, insurability, travel and driving • Provides invaluable information on dealing with common emergencies; what to do and what not to do With a wealth of illustrations (including diagrams, EKGs, CXRs, Echos and cardiac MRIs) and with key point tables, this is an essential guide for all health care professionals managing patients with adult congenital heart disease.

Adult Congenital Heart Disease: Focusing on Intervention

by Munetaka Masuda Koichiro Niwa

This book describes the most popular topics concerning adult congenital heart disease (ACHD), especially focusing on indications and re-intervention procedures for some major ACHDs. Thanks to advances in medical and surgical therapy for congenital heart disease over the last half century, many patients who underwent surgical correction reached adulthood. However, as can be seen from the explosive increase in the number of ACHD patients, postoperative residua and sequelae have also become apparent. The purpose of this book is to highlight complicated problems in connection with ACHD, including its present status, as well as methods for its management including medical and surgical treatment. The content primarily focuses on two areas – general information for cardiologists, and information on re-intervention for interventionists and cardiac surgeons –, setting it apart from the majority of books on congenital heart disease.

Adult Congenital Heart Disease (Oxford Specialist Handbooks in Cardiology)

by Sara Thorne and Sarah Bowater

A practical approach to the investigation and treatment of adult congenital heart disease (ACHD), this fully updated Oxford Specialist Handbook is a concise and accessible overview of a complex condition. Packed with straightforward advice, management strategies and key clinical points, it equips clinicians with a sound understanding of the principles and physiology of ACHD. An ideal reference tool for cardiology trainees, general cardiologists and acute medicine physicians, this second edition of Adult Congenital Heart Disease has been fully reviewed to include new guidelines and increased illustations to aid understanding. Brand new chapters on epidemiology, heart failure, device therapy and transition and transfer of care ensure that Adult Congenital Heart Disease remains the definitive guide to supporting clinicians throughout all aspects of the patient's care.

Adult Congenital Heart Disease (American Heart Association Clinical Series #23)

by Carole A. Warnes

Guides practicing physicians in the practical aspects of how to diagnose and treat patients with congenital heart disease Reviews the most common congenital cardiac anomalies seen in practice Focuses on both clinical evaluation and diagnostic imaging modalities as well as practical management issues, as well as when to refer patients to tertiary care centres Each chapter is preceded by a case study to exemplify the issues which may be challenging in practical management

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