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Mouse Cell Culture: Methods and Protocols (Methods in Molecular Biology #1940)
by Ivan BertoncelloThis volume describes cell culture protocols for the maintenance, propagation, manipulation, and analysis of primary explanted cells from various mouse organ systems. After introductory chapters that examine the applicability of mouse models as a discovery tool and describe critical factors and variables that influence cell culture endpoints, protocol chapters explore cell culture methodologies for specific mouse cell types and lineages. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, comprehensive lists of the essential materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Cell Culture: Methods and Protocols aims to ensure successful results utilizing these protocols in further studies, leading to the identification of key factors, genes, and cellular pathways regulating cell lineage commitment and differentiation, modeling disease, and identifying novel therapeutic targets.
The Mouse Family Robinson
by Dick King-SmithA delightful story with a truly engaging mouse hero - just right for new readers of 7+.If only that horrible cat didn't live here!'When Beaumont Robinson, an inquisitive young mouse, is nearly killed by the cat, his family decide there is only one thing to do. They must emigrate! And so they all set out on a midnight adventure to find a new house.
Mouse Genetics: Methods and Protocols (Methods in Molecular Biology #1194)
by Shree Ram Singh and Vincenzo CoppolaMouse Genetics: Methods and Protocols provide selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages and modeling human diseases. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, a list of necessary materials, systematic, readily reproducible methods and a notes section, which shares tips on troubleshooting in order to avoid known pitfalls.Comprehensive and authoritative, Mouse Genetics: Methods and Protocols promises to deliver fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students and postdoctoral fellows working in the various disciplines of mouse biology and modeling human disease.
Mouse Genetics: Methods and Protocols (Methods in Molecular Biology #2224)
by Shree Ram Singh Robert M. Hoffman Amit SinghThis fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.
Mouse House
by John BurninghamIn the house there lives a family: a mum, a dad, a girl and a boy. But they are not alone; a secret mouse family is living there too, who only come out when everyone else is asleep.One day they are spotted and the mouse catcher is called ... Will they escape in time?A story of home and hope from picture-book genius, John Burningham.
Mouse Mission (A\mousenet Book Ser.)
by Prudence BreitroseIt's An Undercover Adventure! When a remote island's rain forest is threatened by the greedy timber com pany Loggocorp, the Humans Who Know (that mice have evolved) develop a secret plan to save the forest. And they need all the help they can get from the Big Cheese, Trey, and their other friends in the Mouse Nation. First, the team must unravel a centuries-old mystery: Who actually owns the rain forest? The mission to find that person brings Megan and her family across the ocean to England, where everything starts to go just a little bit . . . weird. Loggocorp spies are watching the family's every move as they, too, search for the rightful owner of the island's natural treasure. It's a race against the clock to save the rain forest! The trail leads to a duke's palace full of strange guests and a clan of helpful British mice. And Megan, the most famous human in the world (among mice), has to face her biggest challenge yet.
Mouse Models for Drug Discovery: Methods and Protocols (Methods in Molecular Biology #602)
by Gabriele Proetzel and Michael V. WilesAs the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.
Mouse Models of Cancer: Methods and Protocols (Methods in Molecular Biology #1267)
by Robert Eferl and Emilio CasanovaThis volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.
Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications
by Shaoguang LiIn this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.
Mouse Models of Innate Immunity: Methods and Protocols (Methods in Molecular Biology #1960)
by Irving C. AllenThis second edition presents methods and protocols to aid readers in the design and execution of experiments used to define critical elements associated with innate immune system function. New and updated chapters detail protocols on in vitro and ex vivo studies in key cell types associated with innate immunity and with in vivo protocols used to study immune system function in the mouse. Additionally, chapters describe methods to evaluate innate immune function and new protocols associated with autism, cancer, microfluidics platforms, and CRISPR systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols, Second Edition will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune system.
Mouse Models of Vascular Diseases
by Masataka SataThis book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Mouse (UEB uncontracted)
by Adrian FarnsworthThis is a tactile illustration of a mouse seen from the side and facing to the left.
Mousequerade Ball: A Counting Tale
by Betsy Lewin Lori MortensenIn a castle on a hill, in a great grand hall,mice are getting ready for the Mousequerade Ball.They dress in their finest. What a grand affair!But when an unexpected guest arrives,the mice get quite a scare. Is the evening ruined? Should they run in fright? Or will a gallant mouse stand up and save the splendid night? Counting up to ten and back again, dancing all the while, this delightful story invites readers--and dancers--to the event of the season: the Mousequerade Ball!
Mousequerade Ball: A Counting Tale
by Betsy Lewin Lori MortensenIn a castle on a hill, in a great grand hall,mice are getting ready for the Mousequerade Ball.They dress in their finest. What a grand affair!But when an unexpected guest arrives,the mice get quite a scare. Is the evening ruined? Should they run in fright? Or will a gallant mouse stand up and save the splendid night? Counting up to ten and back again, dancing all the while, this delightful story invites readers--and dancers--to the event of the season: the Mousequerade Ball!
Mouse's Big Day (Twit Twoo School #1)
by Lydia MonksMouse’s Big Day is a warm and funny story about friendship, that’s perfect for any child who is starting school or nursery.It’s Mouse’s first day at school and she’s feeling a little nervous . . . in fact, she doesn’t want to go at all. Luckily, there’s a class full of new friends waiting for her and lots of fun to be had at Twit Twoo School. Can Mouse find the confidence to join in with her classmates and learn just how brilliant school can be? Join Mouse, Frog, Rabbit, Mole, Owl and their teacher, Miss Hoot, at their fun-filled treetop school. With a cast of adorable animal characters and bright, bold, distinctive illustrations from the award-winning Lydia Monks, illustrator of the bestselling What the Ladybird Heard series, the Twit Twoo School series is sure to delight young children.Twit Twoo School: warm and witty stories, perfect for every preschooler. Share more exciting school adventures in Frog Hops Off! and Rabbit Races Ahead!
MOUTHS AND BITS (Threshold Picture Guides #15)
by TONI WEBBERA step-by-step guide to the horse's mouth and the principles of bitting
The Move
by Carol OtienoMonty the Lion and his family are moving house today. Will Monty like his new house and will he meet new friends? Enjoy this new series of books with fantastic artwork.
Move for Life: Gesund durch Bewegung
by Walter ZägeleinIn unserer von Technik geprägten Gesellschaft ist in der Regel mangelnde Bewegung ein zentrales Problem. Diese Bewegungsarmut, die oft gepaart ist mit gutem Essen und zu viel Stress, führt häufig zu den typischen Krankheitssymptomen, die von den Ärzten zusammenfassend als metabolisches Syndrom bezeichnet werden. Auf der anderen Seite existiert ein übertriebener Leistungsgedanke, wie beispielsweise beim Leistungssport, der so manchen über das Ziel hinausschießen lässt. Marathon- und Ultralangstreckenläufe, Triathlon und andere Extremsportarten sind dann der Gegenpol zur Bewegungsarmut der anderen. Was und wie viel an Bewegung sind für die Gesundheit nun wirklich förderlich?Diese Frage und noch vieles mehr beantwortet "Move for Life". Themen sind des weiteren auch die Problematik des Älterwerdens und den daraus resultierenden körperlichen Veränderungen. Es werden nicht nur die Aspekte der Bewegung und deren gesundheitsrelevanten Auswirkungen betrachtet, sondern auch die Notwendigkeiten eines Krafttrainings, eines Koordinationstrainings und eines Entspannungstrainings. Dadurch ergibt sich eine umfassende Darstellung dessen, was der moderne Mensch zu seiner Gesunderhaltung benötigt. Der Leser erhält einen tiefen Einblick in diese Thematik und kann daraufhin selbst entscheiden, was für ihn sportlich und gesundheitlich gesehen gut und richtig ist.
Movement Ecology of Afrotropical Forest Mammals
by Rafael Reyna-Hurtado Colin A. Chapman Mario MellettiThis book brings a unique perspective to animal movement studies because all studies come from African tropical environments where the great diversity, either biological and structurally (trees, shrubs, vines, epiphytes), present the animals with several options to fulfil their basic needs. These conditions have forced the evolution of unique movement patterns and ecological strategies. The book follows on our previous book “Movement Ecology of Neotropical Forest Mammals” but focuses on tropical African forests. Movement is an essential process in the life of all organisms. Animals move because they are looking for primary needs such as food, water, cover, mating and to avoid predators. Understanding the causes and consequences of animal movement is not an easy task for behavioural ecologists. Many animals are shy, move in secretive ways and are very sensible to human presence, therefore, studying the movements of mammals in tropical environments presents logistical and methodological challenges. However, researchers have recently started to be solved these challenges and exciting new information is emerging. In this book we are compiling a set of extraordinary studies where researchers have used new technology and the strongest methodological approaches to understand movement patterns in wild African forest mammals. This second book should inspire early career researchers to investigate wild mammal´s movements in some of the most amazing forest in the world: African tropical forests.
Mozart's Starling
by Lyanda Lynn HauptOn May 27th, 1784, Wolfgang Amadeus Mozart met a flirtatious little starling who sang (an improved version of!) the theme from his Piano Concerto Number 17 in G to him. Knowing a kindred spirit when he met one, Mozart wrote "That was wonderful" in his journal and took the bird home to be his pet. For three years Mozart and his family enjoyed the uniquely delightful company of the starling until one April morning when the bird passed away.In 2013, Lyanda Lynn Haupt, author of Crow Planet, rescued her own starling, Carmen, who has become a part of her family. In Mozart's Starling, Haupt explores the unlikely bond between one of history's most controversial characters and one of history's most notoriously disliked birds. Part natural history, part story, Mozart's Starling will delight readers as they learn about language, music, and the secret world of starlings.
Mr Ape (PDF)
by Dick King-SmithAbandoned by his bossy wife and children, old Mr Ape finds himself living all alone in his huge and rambling house. And then he gets a brilliant idea: he can fill the house with animals the pets his wife and children would never let him have. But pets have a habit of increasing and increasing and soon every room is stuffed to the brim with animals. Something has to change . . .
Mr Darley's Arabian: High Life, Low Life, Sporting Life: A History of Racing in 25 Horses: Shortlisted for the William Hill Sports Book of the Year Award
by Christopher McGrathShortlisted for the William Hill Sports Book of the Year AwardIn 1704 a bankrupt English merchant sent home the colt he had bought from Bedouin tribesmen near the ruins of Palmyra. Thomas Darley hoped this horse might be the ticket to a new life back in Yorkshire. But he turned out to be far more than that: and although Mr Darley's Arabian never ran a race, 95% of all thoroughbreds in the world today are descended from him. In this book, for the first time, award-winning racing writer Christopher McGrath traces this extraordinary bloodline through twenty-five generations to our greatest modern racehorse, Frankel.The story of racing is about man's relationship with horses, and Mr Darley's Arabian also celebrates the men and women who owned, trained and traded the stallions that extended the dynasty. The great Eclipse, for instance, was bred by the Duke who foiled Bonnie Prince Charlie's invasion (with militia gathered from Wakefield races) and went on to lead the Jockey Club. But he only became a success once bought and raced by a card-sharp and brothel-keeper - the racecourse has always brought high and low life together. McGrath expertly guides us through three centuries of scandals, adventures and fortunes won and lost: our sporting life offers a fascinating view into our history. With a canvas that extends from the diamond mines of South Africa to the trenches of the Great War, and a cast ranging from Smithfield meat salesmen to the inspiration for Mr Toad, and from legendary jockeys to not one, but two disreputable Princes of Wales (and a very unamused Queen Victoria), Mr Darley's Arabian shows us the many faces of the sport of kings.
Mr Dog and a Deer Friend (Mr Dog #05)
by Ben Fogle Steve ColeA brand new young fiction series by TV broadcaster and intrepid explorer Ben Fogle, inspired by his real-life animal experiences… Co-written with best-selling children’s author Steve Cole
Mr Dog and a Hedge Called Hog (Mr Dog)
by Ben Fogle Steve ColeA brand new young fiction series by TV broadcaster and intrepid explorer Ben Fogle, inspired by his real-life animal experiences… Co-written with best-selling children’s author Steve Cole and illustrated throughout with beautiful black and white illustrations by Nikolas Ilic.
Mr Dog and the Faraway Fox (Mr Dog)
by Ben Fogle Steve ColeA brand new young fiction series by TV broadcaster and intrepid explorer Ben Fogle, inspired by his real-life animal experiences… Co-written with best-selling children’s author Steve Cole and illustrated throughout with beautiful black and white illustrations by Nikolas Ilic.