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Drug Repurposing for Emerging Infectious Diseases and Cancer

​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.

Behavioural Business: The Psychology of Decisions in Economy, Business and Policy Contexts

This book explores all aspects of the new and emerging area of behavioural business. This book identifies behavioural business as a powerful application of the latest insights and tools from psychology and behavioural science to decision-making in business, management and policy. This book uniquely positions behavioural business as different from both behavioural economics and psychology. This book instead applies a fresh focus on behavioural interventions in policy and business. This book introduces this new area and showcases what it contributes to a number of important contemporary business and policy issues. These include behavioural insights for managers in diverse and multi-cultural workplaces, designers of organisations, interventions, products and services, financial advisors, public policy makers, business creatives and entrepreneurs as well as charity and NGO practitioners. This book summarises state-of-the-art knowledge in the areas of expertise of the authors, who are members of the Behavioural Business Lab at RMIT University in Australia. This book will interest advanced students in related subjects as well as academics and policy makers hoping to learn and apply behavioural insights to their areas of expertise.

Familicide, Gender and the Media: Gendering Familicide, Interrogating News

​This book examines the complex issue of familicide-suicide – the murder of a partner and children followed by suicide. The purpose of the book is two-fold: to advance a feminist sociological analysis of familicide as a form of gender-based violence, and to examine how it is reported on in news. The first section contextualises interpretations of familicide against the dual ascendancy of – and contestation around - feminist and mental illness discourses in public policy and debate. Advancing a feminist sociological analysis of familicide-suicide, it shows the value of ‘continuum thinking’ for understanding complex and varied forms of gender-based violence. Section Two examines Australian news reporting on familicide-suicide, showing the ways cultural assumptions about domestic and family violence and mental illness shape news reporting. It analyses how discourses of gender, disability, age, and the ‘family’ serve to rationalise certain news frames and reflects on the thorny ethical issues inherent in reporting on familicide. Arguing for a nuanced approach to gender-based violence and how it is reported, this book will be of interest for scholars of gender and violence, as well as media and journalism.

Basics of Comprehensive IVUS-Guided PCI

This practical guidebook describes all aspects of the Intravascular Ultrasound (IVUS) for percutaneous coronary intervention (PCI), sharing many tips & tricks for the basic to advanced use of the technology in daily clinical practice. Chapters describe in detail how to interpret several IVUS findings to apply for PCI strategies, help readers understand the pathogenesis in different cases, as well as the mechanisms of PCI. Practical approaches to performing effective PCI will be discussed with case presentations. Chapters outline many practical topics such as reviewing the IVUS images demonstrating plaque characteristics. Also, a hot topic in stentless PCI, and a special section on the relationship between IVUS measurements and physiological assessments including fractional flow reserve (FFR). Basics of Comprehensive IVUS-Guided PCI is a book to be read by PCI operators, interventional fellows, and staff such as radiology technicians, clinical engineering technicians, and nurses in catheterization laboratories. It also attracts engineers and sales representatives working at medical companies who are curious about IVUS-guided PCI. The authors are experts of IVUS-guided PCI and they will broaden the understanding of the technology to entry level to intermediate operators. ​

Modified Rice Bran Arabinoxylan: Therapeutic Applications In Cancer And Other Diseases

Krisenrhetorik und politischer Wandel in China

In diesem Buch wird untersucht, wie das politische System Chinas auf Krisen reagiert. Eine Krise ist ein Ereignis, dessen Auswirkungen nicht allein durch ein geschicktes Management von Zwischenfällen vor Ort kontrolliert werden können, insbesondere in Fällen, in denen weit verbreitete Zweifel an der Legitimität etablierter politischer Paradigmen oder der politischen Ordnung als Ganzes bestehen. Krisen können "politische Fenster" für Interessengruppen schaffen, die die etablierte Politik in pluralistischen Demokratien in Frage stellen. Der politische Kampf zwischen konkurrierenden Definitionen einer unsicheren und mehrdeutigen Situation unter den verschiedenen Akteuren verschafft ihnen einen krisenbedingten Spielraum für dramatische politische Veränderungen. Der Prozess des krisenbedingten politischen Wandels, der hauptsächlich durch die Gestaltung der Krise hervorgerufen wird, ist jedoch in nicht-westlichen Regimen wie China noch nicht ausreichend untersucht worden. Da Chinas Führung die Legitimität des "Sieges" über COVID-19 in den Vordergrund stellt und eine neue Ära der Klimakatastrophen beginnt, wird dieses dynamische Modell der Krise und der Erholung den Wissenschaftlern der chinesischen und globalen Politik Denkanstöße geben.

Data Intelligence and Cognitive Informatics: Proceedings of ICDICI 2022 (Algorithms for Intelligent Systems)

The book is a collection of peer-reviewed best selected research papers presented at the International Conference on Data Intelligence and Cognitive Informatics (ICDICI 2021), organized by SCAD College of Engineering and Technology, Tirunelveli, India, during July 6–7, 2022. This book discusses new cognitive informatics tools, algorithms and methods that mimic the mechanisms of the human brain which lead to an impending revolution in understating a large amount of data generated by various smart applications. The book includes novel work in data intelligence domain which combines with the increasing efforts of artificial intelligence, machine learning, deep learning and cognitive science to study and develop a deeper understanding of the information processing systems.

Gallbladder Cancer: Current Treatment Options

The book discusses the recent progress in understanding the therapeutic targets for gallbladder cancer to provide opportunities for research and for developing innovative strategies that may enhance the benefit of conventional chemotherapy. The book focuses on identifying candidate molecules and the overall status of the targeted therapies available for gallbladder cancer, as there is an urgent need to discover new molecular targets that can guide the emergence of new treatment strategies to improve patient outcomes and act as biomarkers for the early detection of diseases. Recently, new treatment therapeutics targets for gallbladder cancer patients have been identified and the field is evolving rapidly. The book is relevant for the clinical researcher, surgeon, scientist and academician.

A Guide to Mental Health in Family Under the COVID-19 Epidemic

This book tells us from a professional perspective how to deal with stress response in the family, effectively address family problems in the epidemic, and handle the infectious emotions. This book is a profound explanation of the new stress, conflicts, and problems arising at home amid the epidemic. It provides people with a psychological self-help scale to effectively distinguish the normal and abnormal states of psychological response. Besides, it also provides professional psychological assistance and suggestions for special groups, including children, the elderly, the quarantined, and the bereaved, in order to help all families actively respond to the epidemic with the power of psychology.

Die Todesstrafe in Indien: Globale Perspektive, Öffentliches Meinungsbild und psychosoziale Faktoren

Dieses Buch bietet einen umfassenden Überblick über die öffentliche Einstellung zur Todesstrafe in Indien, ergänzt durch eine Zusammenfassung der derzeitigen Anwendung, Abschaffung und Debatte der Todesstrafe weltweit. Das Autorenteam konzentriert sich dabei auf vier Hauptaspekte: die überhöhten Kosten und die unzureichende Verwendung der Mittel, unrechtmäßige Hinrichtungen Unschuldiger, das Versagen der Todesstrafe als wirksames Abschreckungsmittel und die alternative Strafe der lebenslangen Haft ohne Bewährung. Des Weiteren werden insbesondere die öffentlichen Meinungen und Einstellungen zur Todesstrafe als bedeutender Einflussfaktor in den Blick genommen – weltweit und in Indien. Daneben widmet das Autorenteam auch den Opfern der Strafe und deren Familien sowie den am Prozess beteiligten Akteuren (u.a. im Gericht, im Strafvollzug) ein Kapitel und erörtert darin die psychosozialen Konsequenzen für diese Personengruppen. Auf der Grundlage von Meinungsumfragen ist das Buch eine unverzichtbare Lektüre für alle, die sich für Indien, seine Regierung, sein Strafrechtssystem und seine Politik zur Todesstrafe und zu den Menschenrechten interessieren.

Alginate Biomaterial: Drug Delivery Strategies and Biomedical Engineering

This book focuses on recent trends of research on alginate-based biomaterials in Drug Delivery strategies and biomedical engineering. It contains the widely used alginate-based biomaterials as micro to nano-controlled drug delivery (oral, ocular delivery, topical delivery, etc.) and its fabrication technology, characterization, and biomedical aspects (such as cancer therapy, tissue engineering, gene delivery, vaccine delivery, enzyme immobilization, wound healing, dental applications, etc.) in a single book. The chapters cover updated information, current research trends, informatics, and all aspects of applications. Alginate is a U.S. Food and Drug Administration (FDA)-approved natural biomaterial and has diverse biomedical applications. In recent years, researchers and scientists are working on the alginate-based drug delivery systems that have been designed and characterized as a matrix, micro to nanocarriers, fibers, composite/scaffolds, etc. Alginate has versatile properties such as biodegradable, biocompatible, nontoxic, and easily available. This book especially highlights both the drug delivery strategies and biomedical engineering aspects such as controlled drug delivery, drug targeting to the site of action, cancer therapy, gene and vaccine delivery, enzyme immobilization, tissue engineering, and regenerative medicine.

Cognizance of Schizophrenia:: A Profound Insight into the Psyche

This book provides the reader with a thorough understanding of schizophrenia as a complex brain disorder by explaining the various aspects investigated for its cognizance from epigenetics to chemistry and physics to computational approaches. The book covers the key notions of schizophrenia from a variety of facets such as neurogenetics, neurochemistry, neuropharmacology, neurobiology, psychotherapy, psychiatric treatment, cognitive studies, behavioral and societal studies, and computational neurosciences. Individual chapters are focused on crucial topics such as cognitive-behavioral therapy, brain functioning, computational neuroscience, neuro-imaging, and many more. This book explains each section and chapter with utmost clarity to maintain comprehensiveness for every kind of reader. This book covers various classical as well as recent topics from basic to advance level knowledge regarding schizophrenia. The book's contributions regarding its inclusivity of topics, comprehensiveness of language, diversity in knowledge, and focus on the subject will attract all kinds of readers. It can be considered a single comprehensive handy reference book for beginners, including medical students, neuroscientists, researchers, clinicians, and medical practitioners. Cognizance of Schizophrenia will be an invaluable asset for all who are involved in neuroscience research or clinical studies.

The Psychology of Phubbing (SpringerBriefs in Psychology)

This book focuses on the effects of phubbing by parents on their children, partners on their partners, bosses on their employees, friends on their friends, and family members on other family members. Having synthesised the findings from published research about the specific effects on these phubbed individuals in important relationships, the book then presents an exposition of the psychological predictors of phubbing (the triggers), followed by a broader account of the psychological effects of phubbing behaviour. The final chapter looks at the role of social norms in explaining the act of phubbing beyond the individual predictors that trigger the behaviour as it tries to draw a connection between phubbing and social theory.

Dorsolateral Prefrontal Cortex: Working Memory and Executive Functions (Brain Science)

The prefrontal cortex is known to play important roles for performing a variety of higher cognitive functions. Among regions of the prefrontal cortex, the dorsolateral prefrontal cortex plays the most important roles for these functions. This book focuses on functions of the dorsolateral prefrontal cortex, summarizes research results obtained mainly by non-human primate studies, and describes neural mechanisms of executive functions that the dorsolateral prefrontal cortex participates. First, to understand the feature of the dorsolateral prefrontal cortex and how its function has been understood, anatomical and functional features of the dorsolateral prefrontal cortex and historical overview of prefrontal functions are described. To understand functions of the prefrontal cortex and neural mechanisms of executive functions, working memory is an important concept and sustained activation during the memory period of working memory tasks is known as a neural mechanism of working memory. Therefore, this book describes features of sustained memory-related activity based on neurophysiological results obtained in the prefrontal cortex and how memory-related activity contributes to executive functions including control of attention, inhibitory control, task management, and planning. And further, this book describes how the dorsolateral prefrontal cortex contributes to neural mechanisms for sensory and motor processing, memory control in multi-task performance, decision-making, metacognition, and top-down control. Thus, this book provides important information regarding neural mechanisms of dorsolateral prefrontal functions to neuroscientists and helps to plan further investigation to understand prefrontal functions in primates and human subjects.

Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders (Advances in Experimental Medicine and Biology #1411)

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Goal Frustration in Academic Achievement Settings: Theories and Applications

This book provides in-depth description, explanation, and discussion of goal frustration. It brings together a repertoire of perspectives and strategies that educators and scholars from diverse educational contexts have conceptualized and/or implemented in order to monitor, control, or overcome the occurrence of frustration. This book describes the new technologies can be applied in the conceptualization and operationalization of goal frustration. It also discusses the strategies and pedagogies we can use to cope with this emotion. This book offers evidence-based reports of goal frustration as well as data-driven approaches by presenting both theoretical account and empirical evidence that are grounded in educational and psychological research. This work will appeal to a wider readership from practitioners, parents, to educational researchers.

Research and Teaching in a Pandemic World: The Challenges of Establishing Academic Identities During Times of Crisis

This book adopts collaborative autoethnography as its methodology, and presents the collective witnessing of experiences of the COVID-19 pandemic within the higher education sector. Through the presentation of staff and student experiences and what was learnt from them, the authors examine the global phenomenon that is the COVID-19 pandemic through the purposeful exploration of their own experiences. This book presents an overall argument about the state of higher education in the middle of the pandemic and highlights academic issues and region-specific challenges. The reflections presented in this book offer insights for other staff and students, as well as academic policy-makers, regarding the pandemic experiences of those within academia. It also offers practical suggestions as to how we as a global community can move forward post-pandemic.

Advancing Sports and Exercise via Innovation: Proceedings of the 9th Asian South Pacific Association of Sport Psychology International Congress (ASPASP) 2022, Kuching, Malaysia (Lecture Notes in Bioengineering)

This book presents the proceedings of the 9th Asian South Pacific Association of Sport Psychology International Congress (ASPASP) 2022, Kuching, Malaysia, which entails the different sporting innovation themes, namely, Applied Sport and Social Psychology, Health and Exercise, Motor Control and Learning, Counselling and Clinical Psychology, Biomechanics, Data Mining and Machine Learning in Sports amongst others. It presents the state-of-the-art technological advancements towards the aforesaid themes and provides a platform to shape the future direction of sport science, specifically in the field sports and exercise psychology. ​

Managing People in Projects for High Performance: Behavioural Approach to Productive Project Teams (Management for Professionals)

This book examines practically useful management and people skills, and looks at competencies from the micro, meso, and macro- lens. At the micro- level, the book examines a range of competencies needed for managing oneself and others in a project environment, such as personality style, cognitive skills, communication skills, and emotional intelligence. The book will also includes discussion on strategies for managing emotions of self and others effectively. At the meso- level, the book discusses basic structure, characteristics, and importance of different types of teams such as virtual teams, project teams, domain specific teams, and heavy-weight teams in organizations to enhance productivity and delegate accountability. It also explores team processes, including structure, culture, supporting systems, performance and incentive systems, and their impact on team productivity. In addition, the book includes a discourse on skills to manage a multi-generational workforce (a combination of baby boomers, X and Y generation), a challenge faced by project managers in current scenario. Finally, at the macro- level, the book captures the role of culture in a project context; emerging leadership styles in projects, maintaining relationship with internal and external stakeholders; role of power, politics and influence in relationship building (social networks and social capital); and managing conflicts and negotiations. The book presents ethical considerations in managing projects; relationship between projects and sustainability; societal responsibilities of projects; advantages and disadvantages of forms of control in projects (behaviour and outcome control). It is positioned primarily for practitioners although it is a relevant and useful resource and reference for academics and students of project management and management studies courses.

Creating Dynamic Places for Learning: An Evidence Based Design Approach

This book showcases how an evidence-based design approach can be utilized in the planning of learning environments, by acknowledging the interconnectedness of research, practice, and theory as core considerations in the design of learning environments. Toward this end, this volume explores a multi-disciplinary perspective that draws upon modern learning theories, and empirical research from the fields of environmental psychology education, and architectural practice. By presenting this information in an accessible manner, it enables researchers, educators and designers to take actionable steps needed to re-imagine their settings and create dynamic places for learning.

Intellectual Development and Mathematics Learning

This book introduces the outcomes of author’s 40 years of research, especially the theory of “the Triangular Pyramid Structure of Thinking” that he independently proposed, and the application of his development theory in the field of mathematics education. The book firstly explains the substantial character of intelligence, the development law of intelligence, and the relationship between intelligence development and creativity cultivation. Secondly, it discusses the structure of mathematical thinking of children and adolescents from 0 to 18 years old, and the methods of developing students’ thinking ability and the quality of intelligence through arithmetic learning. In the end, this book also demonstrates the characteristics of the development of mathematical thinking ability of children at age 0-6, elementary school students, and secondary school students, and the related latest research in this field. Based on the theory of “the Triangular Pyramid Structure of Thinking”, a number of examples are given to illustrate how the theory of intelligence development can be used in mathematics teaching to promote the development of students’ thinking abilities and to improve the quality of teaching.This book covers various areas including psychology, mathematics, and education. It has a great reference value for scholars in the field of psychology to study the theory of intelligence and the structure of thinking, providing guidance for parents and mathematics teachers to promote children’s quality of intelligence and mathematical thinking abilities, and to enhance their mathematics learning effects. In addition, it provides examples for psychological research to serve specific subject teaching in elementary and secondary schools.

Hearing-Impaired Students’ Intellectual Styles and Their Influence: Distinctive and Shared Characteristics with Hearing Students

This book is the first on the implications of intellectual styles for higher education of students with hearing impairment. It provides a systematic delineation for intellectual styles of students with hearing impairment in comparison with students without hearing impairment. It takes an initial step to present the analysis concerning the mediating role of intellectual styles in the relationships between personal factors and student developmental outcomes.

A Study on Child Development in Contemporary China (Research Series on the Chinese Dream and China’s Development Path)

This book is devoted to the description and analysis of child population, rights to survival and development, culture and policies that Chinese government made in contemporary China. The book pursues three major objectives: firstly, to objectively describe child development in contemporary China ; secondly, to analyze characteristics of child development in contemporary China; and thirdly, to review all types of policies Chinese government has made on children survival, protection and development, which played important roles on promoting child development.

Rhizome Metaphor: Legacy of Deleuze and Guattari in Education and Learning

This comprehensive volume highlights the paradigm shift, creative approaches, and theoretical and practical aspects of rhizomatic learning. The great French theorists Deleuze and Guattari introduced the concept of the rhizome to allow educators to explore the educative process with the rhizomatic lens. The chapters cover digital pedagogies, the conceptual framework of rhizome and nomadic pedagogy in 21st-century education. It creates rhizomatic learning environments and rhizome metaphors to illuminate learning and teacher professional development. It covers an extensive range of issues and challenges related to teaching and learning in the techno centric education systems. It presents an up-to-date and comprehensive analysis of rhizomatic learning approaches in various disciplines. It examines the following key questions: What is the conception of rhizomatic learning and nomadic pedagogy? In which ways can rhizomatic learning transform teaching methods in the digital era? How can educators implement a rhizomatic learning approach in practice? What is the connection between the rhizomatic process and divergent thinking in socially mediated and technology-driven learning environments? Combining theory and practice, this book is essential reading for educational policymakers, teacher educators, university faculty, researchers, instructional designers, learning technologists, teachers, and undergraduate and graduate students worldwide.

Applying Metascientific Principles to Autism Research

This book presents several metascientific strategies and explains how they can be used to improve research about the autism spectrum. It begins with an introduction to the field of metascience and the benefits that it brings to academic disciplines and society. It then outlines recommendations that researchers can adopt so that they do not incorporate specious autism research from predatory publishers into their research activities. An introduction to reproducibility and strategies that can improve the reproducibility of autism research are then outlined. This is followed by chapters about improving the peer review process and reducing the prospect of questionable research practices from occurring. This book concludes with a chapter about strategies that researchers can use to improve the participation of autistics in research. Such knowledge will equip academics, regardless of their experience, with the skills and expertise they need to produce high-quality and inclusive research about the autism spectrum.