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The Origins of COVID-19: China and Global Capitalism
by Li ZhangA new strain of coronavirus emerged sometime in November 2019, and within weeks a cluster of patients began to be admitted to hospitals in Wuhan with severe pneumonia, most of them linked to the Huanan Seafood Wholesale Market. China's seemingly effective containment of the first stage of the epidemic, in glaring contrast with the uncontrolled spread in Europe and the United States, was heralded as a testament to the Chinese Communist Party's unparalleled command over the biomedical sciences, population, and economy. Conversely, much academic and public debate about the origins of the virus focuses on the supposedly "backwards" cultural practice of consuming wild animals and the perceived problem of authoritarianism suppressing information about the outbreak until it was too late. The Origins of COVID-19, by Li Zhang, shifts debate away from narrow cultural, political, or biomedical frameworks, emphasizing that we must understand the origins of emerging diseases with pandemic potential (such as SARS and COVID-19) in the more complex and structural entanglements of state-making, science and technology, and global capitalism. She argues that both narratives, that of China's victory and the racist depictions of its culpability, do not address—and even aggravate—these larger forces that degrade the environment and increase the human-wildlife interface through which novel pathogens spill over into humans and may rapidly expand into global pandemics.
Medicinal Chemistry of Nucleic Acids (Wiley Series in Drug Discovery and Development #16)
by Li He Zhang Zhen Xi Jyoti ChattopadhyayaComplete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.
Medicinal Chemistry of Nucleic Acids (Wiley Series in Drug Discovery and Development #16)
by Li-He Zhang Zhen Xi Jyoti Chattopadhyaya Sidney M. HechtComplete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.
Tissue and Organ Regeneration: Advances in Micro- and Nanotechnology
by Lijie Grace Zhang Ali Khademhosseini Thomas WebsterTissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell-based techniques is that current therapies lack controlled environm
Long Non-Coding RNAs: Methods and Protocols (Methods in Molecular Biology #2372)
by Lin Zhang Xiaowen HuThis second edition provides a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Chapters guide readers through studies used to circular RNAs, RNA splicing, and findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Long Non-Coding RNAs: Methods and Protocols,Second Edition aims to ensure successful results in the further study of this vital field.
Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver
by Ling Zhang Haipeng Shao Serhan AlkanThis book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter.Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists.
HIV Vaccines and Cure: The Path Towards Finding an Effective Cure and Vaccine (Advances in Experimental Medicine and Biology #1075)
by Linqi Zhang Sharon R. LewinThis book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.
Nutritional Toxicology
by Lishi ZhangThis book provides a broad overview of the chemicals in food that have the potential to induce adverse health effects. Nutritional Toxicology is an interaction of nutrition, toxicology, biochemistry and food science, etc. Its main research scope involves the effects of nutrients on metabolisms of toxicants and their mechanisms, the interaction of the toxicants and contaminants originated from diet with nutrients and nutrition process, the adverse health outcome of nutrients excess, as well as methodology of research and related food and nutrition regulation process. Also the risk assessment of toxicants and contaminants in foods, and risk benefit assessment of nutrients (dietary supplementation) has become an emerging topic. This book provides novel and provocative insights into the fields of nutrition, food science and toxicology. It also offers a state-of-the-art report on recent discoveries concerning nutritional toxicology and where the field is going. It mainly focuses on advances made over the past 20 years. It will benefit graduate students, researchers and food and nutrition related regulation parties.
Handbook of Drug Screening
by Litao Zhang Ramakrishna SeethalaBuilding upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery. With extensively updated content and 21 new chapters, this text examines:quality and efficiency of drug target validati
Natural Products: Drug Discovery and Therapeutic Medicine
by Lixin Zhang Arnold L. DemainA fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Surgical Pathology of Non-neoplastic Gastrointestinal Diseases
by Lizhi Zhang Vishal S. Chandan Tsung-Teh WuThis book covers the entire spectrum of non-neoplastic diseases within the gastrointestinal (GI) tract including new entities, recent developments, and questions that arise in the practice of GI pathology. The text is organized by specific organ site, with related disorders of each organ site subgrouped into several chapters based on their common features. Pathologists can quickly find the disorders they are interested and review similar disorders in the same chapter to help them make a correct diagnosis. Each major and common entity is described in detail with its definition, clinical features, pathological features (covering both the gross and microscopic details), differential diagnosis and treatment/prognosis. All chapters also highlight the use of special/immunohistochemical stains and other supporting studies as needed with a focus on providing a practical differential diagnosis rather than just a list of potential associations. This book is extensively illustrated with both gross and microscopic images that act as an integral part of the information provided in the text. Written by practicing GI/liver pathologists and gastroenterologists from the Mayo Clinic, Surgical Pathology of Non-neoplastic Gastrointestinal Diseases serves as a comprehensive yet practical guide for diagnostic surgical pathologists with a passion for GI pathology.
Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium (Advances in Experimental Medicine and Biology #814)
by Lubo Zhang Charles A. DucsayTo celebrate the Center for Perinatal Biology’s 40th Anniversary, an illustrious group gathered at Loma Linda University in February 2013. That gathering of experts and this volume of the proceedings are a tribute to the founder of the Center, Lawrence D. Longo, M.D. These chapters present contributions from individuals who in some way or another were influenced by Dr. Longo. Covering a wide range of topics, and illustrating the diversity of thinking and scientific interests, these proceedings address basic science through to clinical problems in the developmental programming of health and disease.
Modeling the Injury Flow and Treatment after Major Earthquakes
by Lulu ZhangThis book discuss a series of earthquake emergency medical rescue complex models, which can provide theoretical support for medical disaster rescue work in the future. This book consists of three parts. The first part is an introduction (chapter 1) which makes an overview of the purpose, meaning, methods and relative theory using in the research. The second part (chapter 2 to 8) includes “casualty flow” related factors such as the occurrences of earthquake casualty, the Length of Stay among the Hospitalized Patients, the medical evacuation in earthquake and rescue force related factors such as the medical rescue forces allocation in earthquake, the organization and command of earthquake rescue forces, Location and Distribution of Medical Rescue Institutions and from peacetime to wartime in hospital. The third part (chapter 9) is a summary including conclusion and policy-making suggestion.
An Investigation Report on Large Public Hospital Reforms in China (Current Chinese Economic Report Series #0)
by Lulu Zhang Meina Li Feng Ye Tao Ding Peng KangThis book provides a comprehensive understanding of public hospital reform in China, which is a hot topic for China’s new round of health sector reform. The authors use rich data from both health provider side and service user side and conduct a cross-sectional study in China with some comparative analysis between different locations. It provides the audience with a big picture of China’s public hospital and other components of health system as well. The book reviews the main policy measurements in the public hospital reforms and evaluates how these policies influence public hospitals' practices, especially on hospital governance and internal management.
Chronic Rhinosinusitis: The mucosal concept
by Luo Zhang Claus BachertChronic rhinosinusitis (CRS) is one of the most common health care complaints, with the prevalence of 5-12% worldwide. This book aims to present the new findings in mechanism, diagnosis and management of this widespread condition to clinical practitioners. All practical information about CRS is compiled; therefore busy clinicians would not have to perform exhaustive literature studies to diagnose CRS.This book firstly presents the advances in the understanding of epidemiology, genetics, mechanisms, phenotypes, and immunology of this disorder. In the following chapters, details in clinical diagnosis of CRS are summarized, especially clinical characteristics in paediatric CRS. Later chapters introduce medical, surgical, and innovative treatments of CRS, with brief case studies. The role of allergies, asthma, allergic fungal rhinosinusitis, and systemic diseases are also discussed. With the illustrative figures, this book is a comprehensive and quick reference to otolaryngologists, paediatricians, family care physicians, allergists, professional clinical staff, and medical students.
Atlas of Human Body Ultrasound Scanning: Methods And Diagnostic Applications
by Mei ZhangThis atlas describes the diagnosis practice and cases of human body ultrasound. It includes anatomic section, standard scan ultrasonogram of every organ, scanning methods and key points, measurement methods, normal value ranges, and clinical significances of every sections. Providing basic information and fundamental principles of ultrasonic diagnosis, it discusses ultrasound scanning of 14 organs in individual chapters. Each section sonography is accompanied by the scanning method, section structure, measuring method and clinical application. The uniform structure and detailed instructions make this atlas an easy-to-use resource for residents to refer to when they encounter specific ultrasound diagnostic problems.
Get Through MRCPsych CASC (Get Through)
by Melvyn W. Zhang Cyrus S. Ho Roger C. Ho Basant K. PuriThis book is intended for psychiatric trainees sitting the CASC component of the MRCPsych exam. Written by authors with recent exam experience and long-term expertise in the field, the text provides 175 stations closely matched to the subjects that appear in the actual exam, along with concise synopses and guidelines for how to target your revision to enable recall of the most relevant information.
Get Through MRCPsych CASC: Mock Examination Papers (Get Through)
by Melvyn W. Zhang Cyrus S. Ho Roger C. Ho Basant K. PuriThis book is intended for psychiatric trainees sitting the CASC component of the MRCPsych exam. Written by authors with recent exam experience and long-term expertise in the field, the text provides 175 stations closely matched to the subjects that appear in the actual exam, along with concise synopses and guidelines for how to target your revision to enable recall of the most relevant information.
Get Through MRCPsych Paper B: Mock Examination Papers
by Melvyn WB Zhang Cyrus SH Ho Roger CM Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists, are the most important exams for psychiatric trainees to achieve specialist accreditation. Written by authors with recent exam success and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper B: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper B exam.
Get Through MRCPsych Paper B: Mock Examination Papers (Get Through Ser.)
by Melvyn WB Zhang Cyrus SH Ho Roger CM Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists, are the most important exams for psychiatric trainees to achieve specialist accreditation. Written by authors with recent exam success and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper B: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper B exam.
Get Through MRCPsych Paper A1: Mock Examination Papers (Get Through)
by Melvyn WB Zhang Cyrus SH Ho Roger Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists are the most important exams for psychiatric trainee to achieve specialist accreditation. Written by authors with previous exam experience and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper A: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper A exam.
Get Through MRCPsych Paper A1: Mock Examination Papers (Get Through)
by Melvyn WB Zhang Cyrus SH Ho Roger Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists are the most important exams for psychiatric trainee to achieve specialist accreditation. Written by authors with previous exam experience and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper A: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper A exam.
Get Through MRCPsych Paper A2: Mock Examination Papers
by Melvyn WB Zhang Cyrus SH Ho Roger Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists are the most important exams for psychiatric trainee to achieve specialist accreditation. Written by authors with previous exam experience and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper A: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper A exam.
Get Through MRCPsych Paper A2: Mock Examination Papers
by Melvyn WB Zhang Cyrus SH Ho Roger Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists are the most important exams for psychiatric trainee to achieve specialist accreditation. Written by authors with previous exam experience and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper A: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper A exam.
Computational Biomechanics of the Musculoskeletal System
by Ming Zhang Yubo FanComputational biomechanics is an emerging research field that seeks to understand the complex biomechanical behaviors of normal and pathological human joints to come up with new methods of orthopedic treatment and rehabilitation.Computational Biomechanics of the Musculoskeletal System collects the latest research and cutting-edge techniques used in