- Table View
- List View
Surgical and Anaesthetic Instruments for OSCEs: A Practical Study Guide (Master Pass Series)
by Kelvin YanThis book provides an exam-focused revision guide to both anaesthetic and surgical instruments. This is a comprehensive guide to passing an exam station and includes commonly tested knowledge. The Anaesthetic section includes airway, breathing, circulation and analgesia equipment. Surgical instruments include those commonly used in Cardiothoracic Surgery, ENT, General Surgery, Orthopaedics, and Urology. Each instrument entry follows a standard format – description, indications for use, contraindications, and complications. The standard format ensures that the effective learning of each instrument, thereby optimising exam recall. Fully illustrated with all the core anaesthetic and surgical instruments Concise easy to remember text Portable and practical Suitable for a wide range of health professionals The instrument syllabus is a small yet significant part of many exams, and this concise study guide will benefit a wide range of medical and surgical trainees, including those sitting the FRCA and MRCS examinations where this book would serve as a useful adjunct and/or alternative to lengthy textbooks. Healthcare professionals including nurses (ward or theatre), operating department practitioners and physician assistants (PAs) will also find the content useful as an on- the- job aide. About the author Dr Kelvin Yan MRCP AICSM is NIHR Academic Clinical Fellow, University of Oxford and Honorary Clinical Research Fellow, Imperial College London
Surgical and Anaesthetic Instruments for OSCEs: A Practical Study Guide (Master Pass Series)
by Kelvin YanThis book provides an exam-focused revision guide to both anaesthetic and surgical instruments. This is a comprehensive guide to passing an exam station and includes commonly tested knowledge. The Anaesthetic section includes airway, breathing, circulation and analgesia equipment. Surgical instruments include those commonly used in Cardiothoracic Surgery, ENT, General Surgery, Orthopaedics, and Urology. Each instrument entry follows a standard format – description, indications for use, contraindications, and complications. The standard format ensures that the effective learning of each instrument, thereby optimising exam recall. Fully illustrated with all the core anaesthetic and surgical instruments Concise easy to remember text Portable and practical Suitable for a wide range of health professionals The instrument syllabus is a small yet significant part of many exams, and this concise study guide will benefit a wide range of medical and surgical trainees, including those sitting the FRCA and MRCS examinations where this book would serve as a useful adjunct and/or alternative to lengthy textbooks. Healthcare professionals including nurses (ward or theatre), operating department practitioners and physician assistants (PAs) will also find the content useful as an on- the- job aide. About the author Dr Kelvin Yan MRCP AICSM is NIHR Academic Clinical Fellow, University of Oxford and Honorary Clinical Research Fellow, Imperial College London
Operative Techniques in Liver Resection
by Lunan YanThis book presents the latest knowledge in liver resection. It includes preoperative assessment, hepatic vascular occlusion, live parenchyma transection, various liver resection techniques, liver transplantation, ex situ ex vivo resection, auto-transplantation, laparoscopic liver resection and outcome of liver resection. It describes 21 resection techniques in the same style. Each chapter is built around a series of descriptive photographs and illustrations, which are explained in detail in the text. At the end of each section there are key points that are critical for surgeons performing liver resections. The authors share their extensive experience of liver resections. This book will help practitioners perform safe and expeditious resections and reduce postoperative liver failure. Hepato-bilio pancreatic surgeons, hepatologists, radiologists, clinicians and researchers who are interested in liver surgery will find this book an invaluable guide.
Quantitative Methods for Investigating Infectious Disease Outbreaks (Texts in Applied Mathematics #70)
by Ping Yan Gerardo ChowellThis book provides a systematic treatment of the mathematical underpinnings of work in the theory of outbreak dynamics and their control, covering balanced perspectives between theory and practice including new material on contemporary topics in the field of infectious disease modelling. Specifically, it presents a unified mathematical framework linked to the distribution theory of non-negative random variables; the many examples used in the text, are introduced and discussed in light of theoretical perspectives. The book is organized into 9 chapters: The first motivates the presentation of the material on subsequent chapters; Chapter 2-3 provides a review of basic concepts of probability and statistical models for the distributions of continuous lifetime data and the distributions of random counts and counting processes, which are linked to phenomenological models. Chapters 4 focuses on dynamic behaviors of a disease outbreak during the initial phase while Chapters 5-6 broadly cover compartment models to investigate the consequences of epidemics as the outbreak moves beyond the initial phase. Chapter 7 provides a transition between mostly theoretical topics in earlier chapters and Chapters 8 and 9 where the focus is on the data generating processes and statistical issues of fitting models to data as well as specific mathematical epidemic modeling applications, respectively. This book is aimed at a wide audience ranging from graduate students to established scientists from quantitatively-oriented fields of epidemiology, mathematics and statistics. The numerous examples and illustrations make understanding of the mathematics of disease transmission and control accessible. Furthermore, the examples and exercises, make the book suitable for motivated students in applied mathematics, either through a lecture course, or through self-study. This text could be used in graduate schools or special summer schools covering research problems in mathematical biology.
Targeting Lysine Demethylases in Cancer and Other Human Diseases (Advances in Experimental Medicine and Biology #1433)
by Qin YanThis book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications.The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.
Membrane Transporters in Drug Discovery and Development: Methods and Protocols (Methods in Molecular Biology #637)
by Qing YanStudies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.
Pharmacogenomics in Drug Discovery and Development (Methods in Molecular Biology #1175)
by Qing YanCovering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the “root” of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.
Pharmacogenomics in Drug Discovery and Development (Methods in Molecular Biology #448)
by Qing YanThe field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In this book, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. The volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. This book is ideal for scientists striving to transform disease treatment into disease prevention.
Pharmacogenomics in Drug Discovery and Development (Methods in Molecular Biology #2547)
by Qing YanThis new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.
Psychoneuroimmunology: Systems Biology Approaches to Mind-Body Medicine (Methods in Molecular Biology #934)
by Qing YanThis book provides a comprehensive overview of the cutting-edge discoveries and the systems approaches related to the multi-disciplinary field of psychoneuroimmunology (PNI), which may provide the scientific basis for mind-body relationships, and aid in the development of personalized medicine. Specifically, the book focuses on the systems biology studies of complex mechanisms, such as stress and inflammation. There is strong evidence supporting the close relationship between stress, inflammation, and disorders including obesity, cardiovascular disease, diabetes, skin diseases, and sleep disorders. As inflammation is a critical connection among different diseases, further elucidating this connection may contribute to the findings of systemic therapeutic targets. Translational medicine is also addressed, by applying PNI approaches in clinical practice. A major challenge in current bioscience is the translation of basic scientific discoveries into better clinical outcomes. With the understanding of the translational implications of PNI, integrative interventions can be applied to modulate stress responses and to promote healthier behaviors. As an important feature of this book, a broad overview of the PNI-associated integrative interventions is provided. These interventions include nutritional supplements, meditation, and other mind-body strategies. From basic concepts to systems methodologies, from theoretical sources to clinical applications, Psychoneuroimmunology contributes to the understanding and development of PNI toward the establishment of personalized and mind-body medicine.
Psychoneuroimmunology: Methods and Protocols (Methods in Molecular Biology #1781)
by Qing YanThis fully-updated book provides systems-based methodologies and innovative technologies that can be used for solving complicated problems of complex systems. A wide range of theoretical and experimental approaches are introduced for practical applications, as the content explores the basic and novel concepts in psychoneuroimmunology (PNI), especially the relationships among stress, inflammation, and psychophysiological disorders, as well as various cutting-edge technologies and methods for PNI studies, including the utilizations of mouse models and vaccine models. In addition, this book focuses on translational medicine by applying PNI methods in clinical practice. As part of the Methods in Molecular Biology series, the chapters seek to provide a practical, state-of-the-art, and holistic view for the translation of PNI into better preventive and personalized medical practice. Authoritative and hands-on, Psychoneuroimmunology: Methods and Protocols, Second Edition will be of use to biomedical students and professionals at all levels who are interested in integrative studies in psychology, psychiatry, neuroscience, immunology, molecular biology, genetics, bioengineering, physiology, pathology, microbiology, systems biology, and clinical medicine.
Psychoneuroimmunology: Methods and Protocols (Methods in Molecular Biology #934)
by Qing YanPsychoneuroimmunology (PNI) has developed rapidly in the last four decades. As a multidisciplinary area, PNI may provide a scientific basis for mind-body relationships toward the development of personalized and systems medicine. In Psychoneuroimmunology:Methods and Protocols, expert researchers in the field detail methods and protocols geared toward the development of integrative and individualized therapeutics in multiple dimensions from drugs to behaviors. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Psychoneuroimmunology:Methods and Protocols aids scientists in continuing to study holistic views for the translation of psychoneuroimmunology into better preventive and personalized medical practice.
Systems Biology in Drug Discovery and Development: Methods and Protocols (Methods in Molecular Biology #662)
by Qing YanDue to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.
Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 2. Pharmacology and Quality Control
by Xijun YanThis book reviews research on Dan Shen, compiles data from clinical trials and biological experiments, and summarizes the latest research advances. It covers the medicinal herb, herbal pieces, and new proprietary drugs that contain it; it also covers simple and compound, traditional and contemporary formulas, and addresses a broad range of subjects, including: standardized cultivation; biodiversity; effective substances and their biological activities; quality control; and clinical trials. The book goes on to present the clinical trials on Dantonic, especially focusing on its therapeutic effects for coronary heart disease. It discusses compound prescriptions and compatibilities, from the herbal piece level to composition level, and describes approaches to research on modern Chinese medicine.Volume 1 describes the biology and chemistry of Dan Shen, while Volume 2 focuses on pharmacology and quality control. Volume 3 describes the clinical research on Dan Shen.Editor Xijun Yan is the President of Tianjin Tasly Group and a Member of the TCM Standardization Technical Committee. Gathering contributions from more than 100 authors working in the field of pharmaceutical and clinical research, the book presents and analyzes the available information from multiple aspects, reflects the current status of Dan Shen research, and offers an essential reference work for further research and development.
Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 3. Clinical Research
by Xijun YanThis book reviews research on Dan Shen, compiles data from clinical trials and biological experiments, and summarizes the latest research advances. It covers the medicinal herb, herbal pieces, and new proprietary drugs that contain it; it also covers simple and compound, traditional and contemporary formulas, and addresses a broad range of subjects, including: standardized cultivation; biodiversity; effective substances and their biological activities; quality control; and clinical trials. The book goes on to present the clinical trials on Dantonic, especially focusing on its therapeutic effects for coronary heart disease. It discusses compound prescriptions and compatibilities, from the herbal piece level to composition level, and describes approaches to research on modern Chinese medicine.Volume 1 describes the biology and chemistry of Dan Shen, while Volume 2 focuses on pharmacology and quality control. Volume 3 describes the clinical research on Dan Shen.Editor Xijun Yan is the President of Tianjin Tasly Group and a Member of the TCM Standardization Technical Committee. Gathering contributions from more than 100 authors working in the field of pharmaceutical and clinical research, the book presents and analyzes the available information from multiple aspects, reflects the current status of Dan Shen research, and offers an essential reference work for further research and development.
Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 1. Biology and Chemistry
by Xijun YanThis book reviews research on Dan Shen, compiles data from clinical trials and biological experiments, and summarizes the latest research advances. It covers the medicinal herb, herbal pieces, and new proprietary drugs that contain it; it also covers simple and compound, traditional and contemporary formulas, and addresses a broad range of subjects, including: standardized cultivation; biodiversity; effective substances and their biological activities; quality control; and clinical trials. The book goes on to present the clinical trials on Dantonic, especially focusing on its therapeutic effects for coronary heart disease. It discusses compound prescriptions and compatibilities, from the herbal piece level to composition level, and describes approaches to research on modern Chinese medicine.Volume 1 describes the biology and chemistry of Dan Shen, while Volume 2 focuses on pharmacology and quality control. Volume 3 describes the clinical research on Dan Shen.Editor Xijun Yan is the President of Tianjin Tasly Group and a Member of the TCM Standardization Technical Committee. Gathering contributions from more than 100 authors working in the field of pharmaceutical and clinical research, the book presents and analyzes the available information from multiple aspects, reflects the current status of Dan Shen research, and offers an essential reference work for further research and development.
Nanozymology: Connecting Biology and Nanotechnology (Nanostructure Science and Technology)
by Xiyun YanThis book introduces the new concept of “nanozyme”, which refers to nanomaterials with intrinsic enzymatic activity, rather than nanomaterials with biological enzymes incorporated on the surface. The book presents the cutting-edge advances in nanozyme, with emphasis on state-of-the-art applications in many important fields, such as in the biomedical fields and for environmental protection. The nanozyme is a totally new type of artificial enzyme and exhibits huge advantages over natural enzymes, including greater stability, low cost, versatility, simplicity, and suitability for industry. It is of interest to university researchers, R&D engineers, as well as graduate students in nanoscience and technology, and biology wishing to learn the core principles, methods, and the corresponding applications of “nanozyme”.
Bioaerosol Characterisation, Transportation and Transmission: Fundamental, Modelling and Application
by Yihuan Yan Jiyuan TuThis book aims to predict and model the transport of bioaerosols, identify their transmission characteristics, and assess occupants’ infection risks. Although existing epidemiological books provide fundamental infection rate of existing diseases, the ability of predicting emerging disease transmission in the air and assessing occupants’ infection risks to the bioaerosols is significantly lacking. This book is considered as a professional book that provides in-depth discussion of the aforementioned issues and provides potential approaches to solve these issues would be highly demanded by readers in this emerging research field. This book offers essential and systematic analysis on the fate of bioaerosols from their release in the air to the final destination in human’s respiratory systems through direct 3D visualizations techniques. It also provides quantifiable method to assess each occupant’s infection risks to the infectious bioaerosols in indoor environments. The readers will gain essential fundamental characteristics of bioaerosols (active time, viability, etc.) and will gain the advanced skills on how to integrate these properties into numerical modeling and assess the occupants’ exposure risks.
Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology)
by Zhengyin Yan Gary W. CaldwellThis collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. Authoritative and practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.
Projection Matrices, Generalized Inverse Matrices, and Singular Value Decomposition (Statistics for Social and Behavioral Sciences)
by Haruo Yanai Kei Takeuchi Yoshio TakaneAside from distribution theory, projections and the singular value decomposition (SVD) are the two most important concepts for understanding the basic mechanism of multivariate analysis. The former underlies the least squares estimation in regression analysis, which is essentially a projection of one subspace onto another, and the latter underlies principal component analysis, which seeks to find a subspace that captures the largest variability in the original space.This book is about projections and SVD. A thorough discussion of generalized inverse (g-inverse) matrices is also given because it is closely related to the former. The book provides systematic and in-depth accounts of these concepts from a unified viewpoint of linear transformations finite dimensional vector spaces. More specially, it shows that projection matrices (projectors) and g-inverse matrices can be defined in various ways so that a vector space is decomposed into a direct-sum of (disjoint) subspaces. Projection Matrices, Generalized Inverse Matrices, and Singular Value Decomposition will be useful for researchers, practitioners, and students in applied mathematics, statistics, engineering, behaviormetrics, and other fields.
Fearfully and Wonderfully: The marvel of bearing God's image
by Philip Yancey Dr Paul BrandMysterious, intricate, pulsing with energy ... the human body is an endlessly fascinating repository of incredible secrets. In this new work, comprising two classics (Fearfully and Wonderfully Made and In His Image) edited together and updated, renowned surgeon Dr Paul Brand and award-winning writer Philip Yancey take us on a tour of wonder through the human body.Illustrated with stories from Dr Brand's ground-breaking career as a hand surgeon who changed the lives of leprosy sufferers by transforming medical treatment protocols, this lively narrative paints an unforgettable portrait of the incredible unity of the human body in its trillions of parts.As compassionate as he was brilliant, Dr Brand cared as much about his suffering patients as he was intensely curious about how the body works. And so just as his brilliant intuition - which led to medical breakthroughs earning him international awards and acclaim - makes human physiology come alive on the page, so does his deep love for people in their dignity as image-bearers make spirituality come alive on the page as well.Although Brand and Yancey do not presume that readers share their Christian faith, they trace the metaphor of 'one body, many parts' from a medical perspective on human life as well as a mystical perspective on the unifying presence of the Body of Christ. Filled with riveting stories of Dr Brand's work among the marginalized and outcast, this journey of understanding offers astonishing insights and page-turning reading.
Endoscopic Sinus Surgery: A Comprehensive Atlas
by Carlos YañezThis atlas gives careful step-by-step guidance for endoscopic sinus surgery. In doing so, it provides exciting firsthand accounts of modern advanced endoscopic sinus procedures. In the first part of the book the surgical anatomy of the nose and sinuses and the basic surgical techniques are described. The second part deals with advanced techniques and postoperative care. The detailed, step by step narratives - integrated with many intraoperative photographs - accurately convey both surgical fundamentals and nuances. For each procedure the authors give a piece of advice ("golden rules"), making it ideal for those who want to implement well-coordinated surgical approaches to sinus disease.
Aquaporins (Advances in Experimental Medicine and Biology #969)
by Baoxue YangThis book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 – AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 20 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions.
