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Endocannabinoids (Handbook of Experimental Pharmacology #231)
by Roger G. PertweeThere is currently considerable interest in the development of medicines that would enhance endocannabinoid-induced “autoprotection”, for example through inhibition of endocannabinoid metabolizing enzymes or cellular uptake processes or that would oppose endocannabinoid-induced “autoimpairment”. This volume describes the physiology, pathophysiology and pharmacology of the endocannabinoid system and potential strategies for targeting this system in the clinic.
Endocrinology and Diabetes: Case Studies, Questions and Commentaries (Clinical Cases Ser. #29)
by Ramzi Ajjan Stephen M. OrmeThis book provides case studies accompanied by questions and commentaries for the specialist registrar in diabetes and endocrinology, to assist with problem-based learning during their training. The case studies range from the everyday to the rare and complicated, presenting a strong foundation for the specialist trainee to prepare them for their qualifying exams and, more importantly, for their future clinical consultations.
Endodontic Diagnosis, Pathology, and Treatment Planning: Mastering Clinical Practice
by Bobby PatelThis book is intended as a practical guide to endodontic diagnosis, pathology, and treatment planning. The coverage is comprehensive and encompasses such topics as disease classification, the endodontic armamentarium, anatomy, the role of different radiographic techniques, treatment decision making, preoperative management, the use of antibiotics and analgesics, and anesthesia. Numerous high-quality illustrations and clinical photographs are included to highlight key concepts and findings, and best practice is documented by means of clinical case examples. The provision of concise tips and recommendations ensures that the reader will quickly be able to find solutions to diverse endodontic challenges. In addition, the most relevant literature is reviewed in order to support and reinforce the discussed clinical concepts. The book will assist dental practitioners and endodontic trainees/specialists in planning the management of any endodontic case from first principles.
Endodontic Irrigation: Chemical disinfection of the root canal system
by Bettina BasraniThis book reviews the available information on bacterial disinfection in endodontics, with emphasis on the chemical treatment of root canals based on current understanding of the process of irrigation. It describes recent advances in knowledge of the chemistry associated with irrigants and delivery systems, which is of vital importance given that chemical intervention is now considered one of the most important measures in eliminating planktonic microbes and biofilms from the infected tooth. Recommendations are made regarding concentrations, exposure times and optimal sequences. Possible complications related to the use of the different solutions are highlighted, with guidance on response. In addition, clinical protocols are suggested on the basis of both clinical experience and the results of past and ongoing research. Throughout, a practical, clinically oriented approach is adopted that will assist the practitioner in ensuring successful endodontic treatment.
Endogenous ADP-Ribosylation (Current Topics in Microbiology and Immunology #384)
by Friedrich Koch-NolteThis volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:· Evolution and detection of endogenous ADP-ribosylation· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
Endometriosis: A Comprehensive Update (SpringerBriefs in Reproductive Biology)
by Sajal Gupta Avi Harlev Ashok AgarwalThis SpringerBrief provides an update on endometriosis research -- from the underlying mechanisms, predisposing factors, role of environmental pollutants, treatment options, impact on quality of life, and biomarkers, to emerging treatment modalities in order to help clinicians to pursue a patient-centered approach in managing the disease. This book provides clinicians with a better insight into early diagnosis and management of endometriosis. It explores the possible identification of proteins in different types of endometriosis diseases and at different stages of the progression. This may aid in the discovery of potential biomarkers for non-invasive diagnosis of these diseases. The ability to identify a protein, common between women of different races, ages and in different regions of the world will hopefully contribute to improving women’s health worldwide.
Endoscopic Submucosal Dissection: Principles and Practice (The\clinics: Internal Medicine Ser. #24-2)
by Norio FukamiThis volume educates physicians on the basic knowledge of ESD, from indication of this technique to assessing suitability and technical aspects of each important step. The text is structured to guide readers to understand the principles, including history, why ESD was designed and developed, indications, as well as how to evaluate lesions and perform actual procedures. Abundant photographs and diagrams illustrate the key points and promote “pattern recognition”. The text also introduces gastroenterologists to early gastrointestinal lesions, which have not been recognized in clinical practice for many years. To assist in the treatment process of ESD, highly practical information is provided, separated by different anatomical locations, as well as management of complications. The volume is also accompanied by an online video library.Written by experts in Asian countries with vast experience with this technique, as well as experts from the U.S., South America, and Europe, Endoscopic Submucosal Dissection: Principles and Practice provides a major reference for gastroenterologists and surgeons on ESD.
Endoscopic Ultrasonography
by Frank Gress Thomas SavidesYear on year, there continue to be dramatic changes in endoscopic ultrasonography (EUS) since it was first introduced 30 years ago. Advances in technology have meant that as well as being used in the diagnosis of gastrointestinal disorders, EUS is now one of the primary diagnostic and therapeutic modalities used in GI endoscopy. Back and improved for a new edition, Endoscopic Ultrasonography is the market-leading book covering the topic. Written by leading experts in the field, it provides a technical how-to approach to learning this advanced endoscopic procedure. The highly-acclaimed authors provide step-by-step guidance to the fundamentals of EUS, giving clear instructions on the instruments involved, the correct sedation procedures to follow and how EUS should be performed safely and effectively. Every chapter discusses a specific aspect of EUS as it relates to a particular gastrointestinal disorder or organ system. Brand new to this edition are: 1) Seven new chapters on the hottest topics in EUS: Learning Anatomy for EUS; Elastography; Lung Cancer; Autoimmune Pancreatitis; EUS for Liver Disease; Biliary Access; Pancreatic Fluid Collection Drainage 2) A complete update of all previous chapters to reflect the most current clinical recommendations 3) A host of new color images in every chapter Endoscopic Ultrasonography 3rd edition is the ideal tool to consult to improve EUS skills and improve patient management, and an essential purchase for all gastroenterologists and endoscopists.
Endoscopic Ultrasonography
by Frank G. Gress Thomas J. SavidesYear on year, there continue to be dramatic changes in endoscopic ultrasonography (EUS) since it was first introduced 30 years ago. Advances in technology have meant that as well as being used in the diagnosis of gastrointestinal disorders, EUS is now one of the primary diagnostic and therapeutic modalities used in GI endoscopy. Back and improved for a new edition, Endoscopic Ultrasonography is the market-leading book covering the topic. Written by leading experts in the field, it provides a technical how-to approach to learning this advanced endoscopic procedure. The highly-acclaimed authors provide step-by-step guidance to the fundamentals of EUS, giving clear instructions on the instruments involved, the correct sedation procedures to follow and how EUS should be performed safely and effectively. Every chapter discusses a specific aspect of EUS as it relates to a particular gastrointestinal disorder or organ system. Brand new to this edition are: 1) Seven new chapters on the hottest topics in EUS: Learning Anatomy for EUS; Elastography; Lung Cancer; Autoimmune Pancreatitis; EUS for Liver Disease; Biliary Access; Pancreatic Fluid Collection Drainage 2) A complete update of all previous chapters to reflect the most current clinical recommendations 3) A host of new color images in every chapter Endoscopic Ultrasonography 3rd edition is the ideal tool to consult to improve EUS skills and improve patient management, and an essential purchase for all gastroenterologists and endoscopists.
Endoscopy in Inflammatory Bowel Disease
by Richard Kozarek Michael Chiorean Michael WallaceThis book conjoins the latest advances on the use of endoscopy to diagnose, monitor, and treat patients with inflammatory bowel disease. Chapters include the historical use of rigid sigmoidoscopy, non-interventional imaging procedures, and the correlation of pathology and endoscopic visualization. This is the first book to include individual chapters in gastroenterology, colorectal surgery, and IBD texts, the preeminent role of endoscopic imaging in the management of chronic ulcerative colitis, and Crohn's disease. It also includes chapters on capsule endoscopy and balloon and overtube-assisted enteroscopy to define the presence and activity of Crohn's enteritis and additional chapters defining the use of random biopsies versus chromoendoscopy, and computer enhanced imaging to define possible dysplasia development. The book also includes access to online videos, making it the ultimate verbal and visual tool for all medical professionals interested in the advances in the field over the last several decades.Endoscopy in Inflammatory Bowel Disease is a concise text that is of great value to practicing endoscopists, gastroenterologists, general or colorectal surgeons, physicians in training, and all medical professionals caring for patients with inflammatory bowel disease.
Endoscopy in Small Bowel Disorders
by Richard Kozarek Jonathan A. LeightonThis volume reviews the history of endoscopy to diagnose small bowel disorders, places other diagnostic modalities into perspective, and defines the role of capsule endoscopy and per overtube assisted and retrograde enteroscopy in disorders as disparate as gluten sensitive enteropathy, small bowel neoplasms, and inflammatory bowel disease. The book further details the nonoperative approach to NSAID strictures, foreign body retrieval (to include impacted capsule endoscopes), and the diagnosis and treatment of chronically bleeding angiodysplastic lesions. The text is also richly illustrated with over 150 images and includes online video segments.Written by experts in the field, Endoscopy in Small Bowel Disorders is a valuable resource for medical and surgical residents, gastroenterologists in training and practice, therapeutic endoscopists, and general and colorectal surgeons.
Endoskopische Verfahren in der Mund-Kiefer-Gesichtschirurgie: Eine Einführung in das fachbezogene Spektrum (essentials)
by Andreas NeffAndreas Neff zeigt die exzellenten diagnostischen und therapeutischen Optionen der Endoskopie, die für den MKG-Chirurgen bei der komplexen Anatomie der Mund-Kiefer-Gesichtsregion, speziell der Kieferhöhlen und der Nasengänge, des Kiefergelenks, aber auch der Speicheldrüsen heute unverzichtbar ist. Minimalinvasive Darstellung und Zugänge gemäß State of the Art erfordern neben chirurgischem Know-how auch ein spezielles technisches Equipment. Während die Endoskopie in der MKG-Chirurgie meist speziellen Indikationen vorbehalten ist, hat sie insbesondere in der HNO inzwischen einen Großteil der traditionellen direkten bzw. invasiv-offenen Verfahren ersetzt. Auch in der MKG-Chirurgie wird es analog zu ihren Nachbardisziplinen zunehmend zu Paradigmenwechseln in der Behandlungsstrategie kommen, denen sich die MKG-Chirurgie stellen muss, um sich auch in Zukunft auf Augenhöhe weiterentwickeln zu können.
Endosonography E-Book: Expert Consult - Online And Print
by Robert H. Hawes Paul Fockens Shyam VaradarajuluFrom diagnostic to therapeutic procedures, Endosonography, 3rd Edition is an easy-to-access, highly visual guide covering everything you need to effectively perform EUS, interpret your findings, diagnose accurately, and choose the best treatment course. World-renowned endosonographers help beginners apply endosonography in staging cancers, evaluating chronic pancreatitis, and studying bile duct abnormalities and submucosal lesions. Practicing endosonographers can learn cutting-edge techniques for performing therapeutic interventions such as drainage of pancreatic pseudocysts and EUS-guided anti-tumor therapy. Videos detailing various methods and procedures—and more—equip you with a complete overview of all aspects of EUS. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Get a clear overview of everything you need to know to establish an endoscopic practice, from what equipment to buy to providing effective cytopathology services. Understand the role of EUS with the aid of algorithms that define its place in specific disease states. Gain a detailed visual understanding and mastery of how to perform EUS systematically using illustrations, high-quality endosonography images, and videos. Glean all essential, up-to-date information about endosonography including transluminal drainage procedures, contrast-enhanced EUS, and fine-needle aspiration techniques. Benefit from the extensive knowledge and experience of world-renowned leaders in endosonography, Drs. Robert H. Hawes, Paul Fockens, and Shyam Varadarajulu. Locate information quickly and easily through a consistent chapter structure, with procedures organized by body system.
Endothelial Cell Plasticity in the Normal and Injured Central Nervous System
by Esperanza Meléndez Herrera Bryan V. Phillips-Farfán Gabriel Gutiérrez OspinaThis book highlights the importance of endothelial cells as key players in the functioning of the nervous system under both normal and pathological conditions. The book demonstrates that endothelial cells are an essential and dynamic cell population in the central nervous system, with multiple and complex roles, not only in the maintenance of homeo
Endothelial Signaling in Development and Disease
by Mirko Hh Schmidt Stefan LiebnerThis book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.
Endovascular Neurosurgery Through Clinical Cases
by Aristotelis P. MitsosEndovascular neurosurgery is a recently introduced but rapidly evolving medical field, which uses minimally invasive interventions to treat major life-threatening vascular lesions of the Central Nervous System. Although its history counts less than 15 years of worldwide acceptance, it has rapidly displaced the traditional open neurosurgical techniques, being nowadays the first treatment choice for brain aneurysms and vascular malformations. Thus, the experience of each neuroendovascular center and performer is invaluable, offering the base for learning and teaching the new generation of interventionalists as well as for the evolvement of the method itself.This book presents the basic principles of endovascular neurosurgery starting from clinical cases. Through this close-to-clinical-reality-process, the reader will be able to more thoroughly understand the pathophysiology of the brain and spine vascular lesions as well as the decision-making strategy, related to the indications, endovascular methods and results, finding suggestions and solutions to his/her clinical questions and problems. Besides chapters devoted to CNS vascular embryology and anatomy, clinical cases organized in groups based on the treated lesions are introduced: ruptured and unruptured cerebral aneurysms of the anterior and posterior circulation, side-wall and bifurcation aneurysms, arteriovenous malformations (AVM), dural arteriovenous fistulae (dAVF), arterial stenosis and angioplasty as well as spinal vascular lesions. A separate chapter is devoted to the organization and necessary equipment of the angio room and the department offering neuroendovascular service.This volume will be of interest to neurosurgeons, interventional neuroradiologists, vascular surgeons, neurologists and ICU physicians as well as health care providers who are involved in the diagnosis and management of the vascular lesions of the brain and spine.
Energetics of Muscular Exercise
by Guido FerrettiThis book discusses the maximal power and capacity of the three major biochemical pathways - aerobic (oxygen consumption), anaerobic lactic (muscle lactate accumulation in absence of oxygen consumption), and anaerobic alactic (phosphocreatine hydrolysis) metabolism - as well as the factors that limit them. It also discusses the metabolic and cardio-pulmonary mechanisms of the dynamic response to exercise. The way and extent to which the power and capacity of the three major energy metabolisms are affected under a number of different conditions, such as training, hypoxia and microgravity, are also described.
Engineering Mineralized and Load Bearing Tissues (Advances in Experimental Medicine and Biology #881)
by Luiz E. Bertassoni Paulo G. CoelhoThis book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist.Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters.While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes.We envision that this book will represent a valuable reference source for university and college faculties, post‐doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues.
Engineering Patient Safety in Radiation Oncology: University of North Carolina's Pursuit for High Reliability and Value Creation
by Lawrence Marks Lukasz Mazur Bhishamjit Chera Robert AdamsBecause radiation is a central curative and palliative therapy for many patients, it is essential to have safe and efficient systems for planning and delivering radiation therapy. Factors such as rapid technological advances, financial reorganization, an aging population, and evolving societal expectations, however, may be compromising our ability
Entwicklungspsychopathologie und Psychotherapie: Kybernetische Modelle zur funktionellen Diagnostik bei Jugendlichen (essentials)
by Franz Resch Peter ParzerDas Essential vermittelt eine neue Betrachtungsweise in Bezug auf die Psychotherapie von Jugendlichen. Diese sollte nicht nur nosologisch ausgerichtet sein, sondern in der Indikation zu therapeutischen Maßnahmen darüber hinaus auch eine strukturelle und funktionelle Analyse der Symptomatik berücksichtigen, um den Entwicklungsaufgaben, Lebensthemen und dem familiären beziehungsweise außerfamiliären Kontext – also den aktuellen Lebensbedingungen – der Jugendlichen Rechnung zu tragen. Kybernetische Modelle zum zielgerichteten Verhalten erlauben funktionelle Beschreibungen von Symptomverflechtungen, die sich einer direkten therapeutischen Beeinflussung entziehen und nur durch das Auffinden innerer Ziele, in deren Dienst sie stehen, über Verhaltensalternativen verändert werden können.
Environment Exposure to Pollutants (Advances in Experimental Medicine and Biology #834)
by Mieczyslaw PokorskiThe impairment of lung function caused by environmental exposure to pollutants and toxicants is a rising health problem, particularly in highly industrialized parts of the world. The problem is urgently calling for the development of new methodologies to assess both the level of elemental exposure and the effects for quality of health and longevity. This volume provides state-of-the-art information about the recent advances in occupational and non-occupational pollutant-related disorders of the respiratory tract, and the assessment of a threat they pose for the health-span. Heavy traffic-related air pollution, unnoticeable but salient health detriment, is dealt with at length.
Environmental Biomedicine (Advances in Experimental Medicine and Biology #849)
by Mieczyslaw PokorskiThe book presents the latest advances in research into health effects of air pollution, with heavy motor vehicle traffic or cigarette smoke as the exemplar of pollution. The airways are the first-line defense system against pollution. The book focuses on respiratory ailments underlain by inflammation, increased susceptibility to infection, particularly acquired during harsh environmental conditions and exposures to particulate matter or pathogens. The importance of astute analysis of lung function for early diagnosis of disorders is underscored. A knowledge deficit concerning the aerosolized drug delivery through the airways also is addressed. Recent developments and viewpoints in the field of environmental health hazards as well as methodological advances in their assessment are provided. The book will be of interest to pulmonologists, healthcare providers, researchers and clinicians engaged in environment-related respiratory diseases, but also to policy makers concerned with clean ambient air quality.
Environmental Epigenetics (Molecular and Integrative Toxicology)
by L. Joseph Su Tung-Chin ChiangThis book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases.Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology.This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology.This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.
Environmental Hazards and Neurodevelopment: Where Ecology and Well-Being Connect
by Cindy CroftThis title includes a number of Open Access chapters.The rate of identification of children with neurobiological disabilities has been on the increase in recent years. Millions of dollars in research are being spent to understand the factors influencing these increases. The articles within this compendium shed vital light on this issue, confirming
Epidemiology for Field Veterinarians: An Introduction
by Evan Sergeant Nigel PerkinsIntended as an introduction for veterinarians and other animal health professionals interested in and wishing to apply epidemiological methods in their day-to-day work, this book provides a practical guide for those new to the field. Its applied focus covers the principles of epidemiology in real world situations and practical implementation of disease outbreak investigation, for both emerging and endemic diseases. Techniques and methods are discussed, supported by case studies and practical examples to illustrate their application. The book is clearly written and accessible, providing readers with practical information and encouraging the development of problem-solving skills. It is an essential handbook for veterinary surgeons and students and those involved in animal health, food safety and epidemiology.