Pharmacokinetics of Drugs (1994) (Handbook of Experimental Pharmacology #110)

By: G. L. Amidon and J.P.F. Bai and L. P. Balant and C. M. Barksdale and I. A. Blair and D. D. Breimer and M. Chiba and J. Delforge and M. Eichelbaum and B. L. Ferraiolo and A. J. Fischman and M. Gex-Fabry and N. Holford and J. Kantrowitz and H. K. Kroemer and T. M. Ludden and J. M. Mayer and B. Maziere and C. McMartin and G. Minkus and M. A. Mohler and G. D. Nordblom and R. O'Neill and K. S. Pang and O. Pelkonen and A. Racine-Poon and R. H. Rubin and J. L. Steimer and B. H. Stewart and H. W. Strauss and B. Testa and S. Vozeh and P. G. Welling and R. G. Wills and A. Yacobi

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Synopsis: A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.