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Advanced Digestive Endoscopy: ERCP
by Peter B. Cotton Joseph W. LeungAdvanced Digestive Endoscopy: ERCP addresses some of the most complex diagnostic and therapeutic procedures for endoscopists. It provides the latest thinking and clear instruction on the techniques, which have been integrated with overall patient care. Written by the leading international names in endoscopy, the text has been expertly edited by Peter Cotton into a succinct, instructive format. Presented in short paragraphs structured with headings, subheadings and bullet points and richly illustrated throughout with full-color photographs.
Advanced Drug Delivery
by Ashim Mitra Chi H. Lee Kun ChengProvides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.
Advanced Drug Delivery
by Ashim Mitra Chi H. Lee Kun ChengProvides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.
Advanced Drug Delivery: Methods and Applications (Studies in Mechanobiology, Tissue Engineering and Biomaterials #26)
by Tuhin Subhra Santra Ashwini Uma Surendra ShindeThis book provides an overview of various drug delivery systems at the cellular level including biological, chemical methods, and most importantly physical methods such as photoporation, electroporation, mechanoporation, and device-based techniques (e.g., microfluidics), as well as organism-level techniques including nanomaterials, biomaterials, and transdermal. Drug delivery (DD) can be defined as the method and route by which an active pharmaceutical ingredient (API) is administered to promote its desired pharmacological effect and/or convenience and/or to reduce adverse effects. Drug delivery systems are developed to maximize drug efficacy and minimize side effects. As drug delivery technologies improve, the drug becomes safer and more comfortable for patients to use. During the last seven decades, extraordinary progress has been made in drug delivery technologies, such as systems for long-term delivery for months and years, localized delivery, and targeted delivery. The advances, however, will face the next phase considering the future technologies that we need to overcome many physicochemical barriers for new formulation development and biological unknowns for treating various diseases. Thus, various technologies are built at a single-cell level as well as an organism level. This book is useful at the university level for graduate courses or research studies and biotechnology-based companies with research and development on cell-based analysis, diagnosis, or drug screening. This book is also very useful for researchers in drug delivery technologies, which came in frontier research for the past decade.
Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases
by Dinesh Kumar Chellappan Kavita Pabreja Md. FaiyazuddinThis book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
Advanced Drug Formulation Design to Optimize Therapeutic Outcomes
by Robert O. Williams David R. Taft Jason T. McConvilleThis title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targ
Advanced Electroporation Techniques in Biology and Medicine
by Andrei G. Pakhomov Damijan Miklavcic Marko S. MarkovA reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of biomembranes by pulsed electric fields. Edited by experts and
Advanced Endourology: The Complete Clinical Guide (Current Clinical Urology)
by Stephen Y. Nakada Margaret S. PearleLeading national and international urologists in the field of endourology describe standard and advanced endoscopic procedures for treating upper-tract pathology. The authors provide step-by-step instructions for the latest endoscopic procedures, ranging from upper urinary tract calculi and strictures to urothelial cancer. Advanced Endourology: The Complete Clinical Guide offers practicing urologists and urology residents not only a comprehensive, illustrated guide to endourological techniques-particularly the more advanced procedures-but also a practical means to expand the range and scope of the procedures they perform.
Advanced Endovascular Therapy of Aortic Disease
by Alan B. Lumsden Peter H. Lin Changyi Chen Juan ParodiAt last, years of clinical experience and the latest clinical evidence comes together in one comprehensive collection by world-renown experts at the Baylor College of Medicine. A complete and focused examination of all aspects of endovascular therapy of aortic disease, Advanced Endovascular Therapy provides you with all of the information you need on: Natural history and preoperative planning Thoracic aortic aneurysm Aortic dissection and traumatic aortic injury Techniques, new devices, and surveillance With 26 chapters skilfully organized into four main sections, this book helps you obtain the best results when using endovascular treatments for patients with aortic disease. Keep Advanced Endovascular Therapy close at hand for frequent reference.
Advanced ENT training: A guide to passing the FRCS (ORL-HNS) examination
by Joseph Manjaly Peter KullarThe syllabus for the FRCS (ORL-HNS) is vast and sound preparation for the exams has traditionally involved assimilatiing knowledge from a wide range of sources. This book provides a focussed guide for exam candidates. More than a question and answer book, this book is a coaching manual. Each section features a combination of model answers, pearls of wisdom, checklists and pointers for further reading. Detailed advice is provided for both Part 1 and Part 2 of the examnation. Viva topics that have featured in the exam in recent years have been included. and have then been supplemented by invaluable editorial contributions from leaders in each of the subspecialties. Trainees frequently comment that exam preparation is an enlightening process and the knowledge gained would have served them well during their time as an ENT registrar or Otorhinolaryngology resident.This book will also serve as a valuable learning tool for trainees as early as ST3 and facilitate their development of effective and safe clinical practice.
Advanced ENT training: A guide to passing the FRCS (ORL-HNS) examination
by Joseph Manjaly Peter J KullarThe syllabus for the FRCS (ORL-HNS) is vast and sound preparation for the exams has traditionally involved assimilatiing knowledge from a wide range of sources. This book provides a focussed guide for exam candidates. More than a question and answer book, this book is a coaching manual. Each section features a combination of model answers, pearls of wisdom, checklists and pointers for further reading. Detailed advice is provided for both Part 1 and Part 2 of the examnation. Viva topics that have featured in the exam in recent years have been included. and have then been supplemented by invaluable editorial contributions from leaders in each of the subspecialties. Trainees frequently comment that exam preparation is an enlightening process and the knowledge gained would have served them well during their time as an ENT registrar or Otorhinolaryngology resident.This book will also serve as a valuable learning tool for trainees as early as ST3 and facilitate their development of effective and safe clinical practice.
Advanced ERCP for Complicated and Refractory Biliary and Pancreatic Diseases
by Dong Ki LeeThis book provides a comprehensive overview of non-surgical treatments for complicated and refractory biliary and pancreatic lesions. In particular, it offers non-surgical treatment options for benign biliary strictures. For those suffering from intractable total biliary obstruction following biliary operation, magnetic compression anastomosis represents a good therapeutic option, and this technique is fully explained. Moreover, the book describes diverse treatment modalities for hilar stricture, which is one of the most challenging areas of ERCP. Several chapters cover a variety of important aspects of this area. The book also aims to identify and solve the unmet needs for the diagnosis and treatment of biliary and pancreatic diseases. The precise explanations of treatment concepts and strategies will both increase readers’ knowledge and provide assistance in daily clinical practice. The authors are pioneering experts from around the world, and the text is supported by numerous informative illustrations and helpful summaries.
Advanced Evoked Potentials (Topics in Neurosurgery #2)
by Hans LüdersOver the last twenty to thirty years the progressivcly increasing availability of averaging machines has made evoked potential testing available not only in the major neurological diagnostic centers but also in the office of many neuro logists in private practice. This rapid devclopment was closely paralleled by clinical research in evoked potentials and the publishing of books covering in detail the basic techniques necessary to obtain evoked potentials and the main clinical applications of evoked potentials. Less work was done, however, to define some of the general principles underlying the recording of evoked potentials or to analyze critically the recording techniques or the actual prac tical value of the information provided by evoked potential testing. In this book an attempt has been made to cover this gap. It is assumed that the reader has a good understanding of basic recording techniques and is familiar with the main applications of clinical evoked potentials. The main emphasis of the first two chapters is to define with more precision some of the physical principles that inftuence the volta ge distribution and are used for defining the generator sources of evoked potentials. This is followed by a critical analysis of recording techniques and of its main clinical applications. Finally there is one chapter that gives an overview on application of evoked potentials for surgical monitoring. This is a rapidly growing field that also has been covered only incomplctcly in previous publications.
Advanced Flow Cytometry: Applications in Biological Research
by R. C. Sobti and Awtar KrishanFlow cytometry has rapidly evolved into a technique for rapid analysis of DNA content, cellular marker expression and electronic sorting of cells of interest for further investigations. Flow cytometers are being extensively used for monitoring of cellular DNA content, phenotype expression, drug transport, calcium flux, proliferation and apoptosis. Phenotypic analysis of marker expression in leukemic cells has become an important tool for diagnostic and therapeutic monitoring of patients. Recent studies have explored the use of flow cytometry for monitoring hormone receptor expression in human solid tumors and for studies in human genomics. Contributions in the current volume are based on presentations made at the First Indo-US workshop on Flow Cytometry in which experts from USA, UK and India discussed applications of flow cytometry in biological and medical research. This book will be of interest to post graduates and researchers in the fields of pathology, cytology, cell biology and molecular biology.
Advanced Fluorescence Microscopy: Methods and Protocols (Methods in Molecular Biology #1251)
by Peter J. VerveerThis volume provides an overview of advanced fluorescence microscopy, covering a broad range of methods. Each chapter focuses on a different method and provides a practical guide for application in biological systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Advanced Fluorescence Microscopy: Methods and Protocols seeks to provide scientists with methods for biological systems that are of interest.
Advanced Fluorescence Reporters in Chemistry and Biology I: Fundamentals and Molecular Design (Springer Series on Fluorescence #8)
by Alexander P. DemchenkoFluorescence reporter is the key element of any sensing or imaging technology. Its optimal choice and implementation is very important for increasing the sensitivity, precision, multiplexing power, and also the spectral, temporal, and spatial reso- tion in different methods of research and practical analysis. Therefore, design of ?uorescence reporters with advanced properties is one of the most important problems. In this volume, top experts in this ?eld provide advanced knowledge on the design and properties of ?uorescent dyes. Organic dyes were the ?rst ?uorescent materials used for analytical purposes, and we observe that they retain their leading positions against strong competition of new materials – conjugated polymers, semiconductor nanocrystals, and metal chelating complexes. Recently, molecular and cellular biology got a valuable tool of organic ?uorophores synt- sized by cell machinery and incorporated into green ?uorescent protein and its analogs. Demands of various ?uorescence techniques operating in spectral, anisotropy, and time domains require focused design of ?uorescence reporters well adapted to these techniques. Near-IR spectral range becomes more and more attractive for various applications, and new dyes emitting in this range are strongly requested. Two-photonic ?uorescence has become one of the major tools in bioimaging, and ?uorescence reporters well adapted to this technique are in urgent need. These problems cannot be solved without the knowledge of fundamental principles of dye design and of physical phenomena behind their ?uorescence response.
Advanced Fluorescence Reporters in Chemistry and Biology II: Molecular Constructions, Polymers and Nanoparticles (Springer Series on Fluorescence #9)
by Alexander P. DemchenkoWith contributions by numerous experts
Advanced Fluorescence Reporters in Chemistry and Biology III: Applications in Sensing and Imaging (Springer Series on Fluorescence #10)
by Alexander P. DemchenkoThe key element of any fluorescence sensing or imaging technology is the fluorescence reporter, which transforms the information on molecular interactions and dynamics into measurable signals of fluorescence emission. This book, written by a team of frontline researchers, demonstrates the broad field of applications of fluorescence reporters, starting from nanoscopic properties of materials, such as self-assembled thin films, polymers and ionic liquids, through biological macromolecules and further to living cell, tissue and body imaging. Basic information on obtaining and interpreting experimental data is presented and recent progress in these practically important areas is highlighted. The book is addressed to a broad interdisciplinary audience.
Advanced Functional Materials for Optical and Hazardous Sensing: Synthesis and Applications (Progress in Optical Science and Photonics #27)
by Rakesh Kumar Sonker Kedar Singh Rajendra SonkawadeThis book highlights the significance and usefulness of nanomaterials for the development of sensing devices and their real-life applications. The book also addresses various means of synthesizing functional materials, e.g., hydrothermal deposition process, electrospinning, Ostwald ripening, sputtering heterogeneous deposition, liquid-phase preparation, the vapor deposition approach, and aerosol flame synthesis. It presents an informative overview of the role of functional materials in the development of advanced sensor devices at the nanoscale and discusses the applications of functional materials in different forms prepared by diverse techniques in the field of optoelectronics and biomedical devices. Major features, such as type of advanced functional, fabrication methods, applications, tasks, benefits and restrictions, and saleable features, are presented in this book. Advanced functional materials for sensing have much wider applications and have an enormous impact on our environment.
Advanced Fuzzy Logic Technologies in Industrial Applications (Advances in Industrial Control)
by Ying Bai Hanqi Zhuang Dali WangThis book introduces a dynamic, on-line fuzzy inference system. In this system membership functions and control rules are not determined until the system is applied and each output of its lookup table is calculated based on current inputs. The book describes the real-world uses of new fuzzy techniques to simplify readers’ tuning processes and enhance the performance of their control systems. It further contains application examples.
Advanced Genetic Counseling: Theory and Practice
by Barbara B. Biesecker Kathryn F. Peters Robert RestaA CRITICAL NEW APPROACH FOR LEARNING AND THRIVING IN A FIELD OF CHANGE The scope and responsibilities of today's genetic counselors exceed the reasonable capacity of any one educational resource. While the field's first-year curriculum may be relatively fixed, the landscape of what comes after that -- a dizzying mix of practice, ethics, research design, and professional competencies -- is increasingly broad. Advanced Genetic Counseling offers an overdue extension of the field's core curriculum. From navigating ethical dilemmas and potential conflicts of interest to confronting the biases and patterns of thought that can limit counselors' interactions with clients, it prepares readers to face the profession's most challenging aspects with confidence. Drawing on techniques from psychotherapy, social psychology, and health behavior, Advanced Genetic Counseling is an essential resource for trainees and mid-career professionals. It offers a roadmap not just for addressing client needs, but for the future of genetic counseling education.
Advanced Genetic Counseling: Theory and Practice
by Barbara B. Biesecker Kathryn F. Peters Robert RestaA CRITICAL NEW APPROACH FOR LEARNING AND THRIVING IN A FIELD OF CHANGE The scope and responsibilities of today's genetic counselors exceed the reasonable capacity of any one educational resource. While the field's first-year curriculum may be relatively fixed, the landscape of what comes after that -- a dizzying mix of practice, ethics, research design, and professional competencies -- is increasingly broad. Advanced Genetic Counseling offers an overdue extension of the field's core curriculum. From navigating ethical dilemmas and potential conflicts of interest to confronting the biases and patterns of thought that can limit counselors' interactions with clients, it prepares readers to face the profession's most challenging aspects with confidence. Drawing on techniques from psychotherapy, social psychology, and health behavior, Advanced Genetic Counseling is an essential resource for trainees and mid-career professionals. It offers a roadmap not just for addressing client needs, but for the future of genetic counseling education.
Advanced Glaucoma Surgery (Essentials in Ophthalmology)
by Ahmad A. Aref Rohit VarmaThis text provides expert instruction on the techniques currently employed for the surgical treatment of glaucomatous disease, covering both the host of novel microinvasive devices for treatment of milder stages and the refined strategies that enhance success rates in patients with advanced disease. The critical steps in each procedure are clearly described with the aid of many high-quality illustrations and surgical videos. Pearls and pitfalls of the various techniques are highlighted, and helpful information is provided on indications, preoperative considerations, potential intra- and postoperative complications, and strategies for reducing the incidence of such adverse events. Each treatment method is addressed in a dedicated stand-alone chapter, ensuring ease of reference for the practitioner. Readers will find this book, written by internationally recognized experts in the field, to be an exceptional source of up-to-date information on advanced glaucoma surgical techniques.
The Advanced Handbook of Methods in Evidence Based Healthcare (PDF)
by Mr John Brazier Mr Ray Fitzpatrick Professor Andrew J Stevens Professor Keith R Abrams Richard J Lilford'This handbook is an excellent reflection of the growing maturity and methodological sophistication of the field of Health Technology Assessment. The Handbook covers a spectrum of issues, from primary evidence (clinical trials) through reviews and meta-analysis, to identifying and filling gaps in the evidence. Up-to-date, clearly written, and well-edited, the handbook is a needed addition to any personal or professional library dealing with Health Technology Assessment.' Professor David Banta, TNO Prevention and Health, The Netherlands 'This text presents the most advanced knowledge on methodology in health care research, and will form the backbone of many future studies' - Paula Roberts, Nurse Researcher The `effectiveness revolution' both in research and clinical practice, has tested available methods for health services research to the extreme. How far can observational methods, routine data and qualitative methods be used in health care evaluation? What cost and outcome measures are appropriate, and how should data be gathered? With the support of over two million pounds from the British Health Technology Assessment Research Programme, the research project for this Handbook has led to both a synthesis of all of the existing knowledge in these areas and an agenda for future debate and research. The chapters and their authors have been selected through a careful process of peer review and provide a coherent and complete approach to the field. The handbook has been a unique collaboration between internationally regarded clinicians, statisticians, epidemiologists, social scientists, health economists and ethicists. It provides the most advanced thinking and the most authoritative resource for a state of the art review of methods of evaluating health care and will be required reading for anyone involved in health services research and management.
Advanced Handbook of Systemic Lupus Erythematosus
by Laurent Arnaud Ronald Van VollenhovenThis book will provide an introduction to the epidemiology, etiology and pathogenesis of the condition while also exploring the classification, diagnosis, and current and emerging therapies for systemic lupus erythematosus. Systemic lupus erythematosus is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs. The underlying cause of the disease is not fully known, and SLE is much more common in women than in men. It may occur at any age but most often occurs in people between 10 and 50 years of age. This is the second Adis title from Ronald F van Vollenhoven, who previously authored Biologics for the Treatment of Rheumatoid Arthritis.